The potential of probiotics for treating acne vulgaris: A review of literature on acne and microbiota

Abstract

Acne is known as a chronic inflammatory skin disease with sever adverse effects on quality of life in the patients. The increasing resistance to antibiotics has decreased their effectiveness in treating acne. As viable microbial dietary supplements, probiotics provide health benefits through fighting pathogens and maintaining the homeostasis of the gut and skin microbiome. The present article reviewed the potential of probiotics as beneficial microorganisms for treating acne vulgaris. This review of literature was conducted through a bibliographic search of popular databases, including Science Direct, PubMed, Scielo and Medline, using keywords such as probiotics, prebiotics, synbiotics, microbiome, and acne vulgaris to determine potential applications of these beneficial microbiomes in treating acne vulgaris. Acne lesions are associated with increases in proportion of Propionibacterium acnes as a skin commensal bacterium. The environmental studies showed inhibitory effects of probiotics on P. acnes, mediating by antibacterial proteins and bacteriocin‐like inhibitory substances, and their immunomodulatory effects onkeratinocytes and epithelial cells. Probiotics were also found to inhibit cytokine IL‐8 in epithelial cells and keratinocytes, suggesting immunomodulatory activities. Moreover, glycerol fermentation by Staphylococcus epidermidis was found to be a natural skin defense against acne and an overgrowth inhibitor of P. acnes. As an antimicrobial agent in lotions and cosmetic formulations, Lactococcus sp. can decrease the inflammatory mediators that are produced by P. acnes and cause vasodilation, edema, mast cell degranulation and TNF‐alpha release. Oral administration of probiotics was found to constitute an adjuvant therapy to conventional modalities for treating mild‐to‐moderate acne vulgaris.

Electricity-Producing Staphylococcus Epidermidis Counteracts Cutibacterium Acnes

“…Electrogenic S. epidermidis impedes the growth of C. acnes. Since both S. epidermidis and C. acnes are bacterial members in an acne microbiome 39 , we sought to assess if electricity generated by S. epidermidis in the presence of PEG-8 Laurate can alter the growth of C. acnes. The culture media of S. epidermidis plus PEG-8 Laurate which elicited the high and low voltage peaks at 60 and 300 min, respectively (Fig.…”

The healing effects of facial BOTOX injection on symptoms of depression alongside its effects on beauty preservation

“…What we discussed in this study was to investigate whether using botulinum injections as a common method of improving facial es- Change of lifestyle and notice to cosmetic and therapeutic aspects of many dermatologic concerns and disorders results in better management of them and logically impacts on psychological issues especially about immune-mediated dermatologic disorder like psoriasis, vitiligo and lichen planus, [20][21][22] acne, [23][24][25][26][27] melasma and pimentary disorders, [28][29][30][31] scars, [32][33][34] and alopecia, 35 that is, what we approached in this study, too.…”

Development and characterization of a 3D in vitro model mimicking acneic skin

“…17 This chemokine secretion might be PAR-2 (Proteinaseactivated receptor-2)-dependent. 44 As targeting the inflammatory response is essential when developing anti-acne therapeutic solutions, 45,46 our model secreting high levels of various pro-inflammatory cytokines is accordingly a suitable tool. to mimic acne-prone skin and could become the basis of a screening tool dedicated to anti-acne treatments.…”