The potential of pre-columns to improve detection properties in high-performance liquid chromatography

Jong, Gerhardus J. de; Zeeman, J.

doi:10.1007/bf02261608

Cited by 12 publications

(1 citation statement)

References 23 publications

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“…[51]. Other derivatizing agents have also been used to improve the sensitivity of the assay as 4-fluoro-7-nitrobenzofurazan [52], fluorescamine [53], and dansyl chloride [54]. However, while using fluorescamine and dansyl derivatives, there might be a possibility of poor photo stability and band broadening of the resulted peaks.…”

Section: Fluorescence Detectormentioning

confidence: 99%

Trends and Advances in Separation and Detection of SSRIs and SNRIs in Biological Matrices

Das

Agrawal

2013

Chromatography Research International

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Nowadays antidepressant drugs like selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs) represent the first choice in the treatment of moderate to severe depressive illness, various phobias, and personality disorders. In spite of the therapeutic aspects, they often produce very severe and toxic effects in deliberate and accidental cases of poisoning. These are also considered as date-rape drugs used for drugged victims for raping or robbing. Therefore, in recent years, their analyses in different biological matrices for clinical and toxicological analysis purposes has been a target worthy of interest. Thus, the review focuses on recent advancements of various separation techniques like chromatography and electrophoresis that are concernd with the determination of selective serotonin reuptake inhibitor and selective norepinephrine reuptake inhibitor drugs and their metabolites in various biological matrices. In addition to this, a critical discussion on analytical approaches has also been incorporated, suggesting their applicability and limitations for further implementations. Thus, this paper will definitely help in the selection and development of proper analytical methodologies to achieve satisfactory results, better scientific understanding, and test interpretation.

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