Development and Application of an HPLC Pre-Concentration Device Suitable for Large Amounts of Biological Sample

Photo-isomerization of fluvoxamine in aqueous solutions

“…As mentioned above, the same photoproduct was previously detected and identified [7]. A paper has reported that the (Z)-isomer of fluvoxamine accounted for 3% in original standard [1]. Before this experiment we confirmed that no (Z)-iosmer of fluvoxamine was present.…”

“…also (Z)-isomer by isomerization of oxime moiety of fluvoxamine. Ruijten et al [1], however, has reported 11 different metabolites of fluvoxamine in the four animals and has also reported that most of the metabolites contain both (E)-isomer and (Z)-isomers. The oxime isomerization can be induced by temperature, light, H + and OH − ions, and a solvent [25].…”

“…It is the only achiral SSRI currently on the market, selectively inhibiting the neuronal uptake of serotonin. Ruijten et al [1] has reported that fluvoxamine is completely metabolized in rats, hamsters, and mice, and to about 90% in dogs. In their study, the major metabolite in dogs, rats, and hamsters was the carboxylic acid formed by oxidative elimination of the methoxy group.…”

“…Foda et al [10] have cited a number of LC analysis methods for the determination of fluvoxamine and some methods are also reported such as high-performance liquid chromatography (LC) [1,[11][12][13], gas chromatography [14][15][16], and capillary electrochromatography [17].…”