The Potential of Hematopoietic Stem Cells (Hsc) Against Sars-Cov-2 (Covid-19) With Virus Isolates From Indonesia (In Vitro Study)

Sumorejo, Purwati; Purnama, Disca Sandyakala; Miatmoko, Andang; Nasronudin, Nasronudin; Dinaryanti, Aristika; Karsari, Deya; Hendrianto, Eryk; Ihsan, Igo Saiful; Ertanti, Nora; Asmarawati, Tri Pudy; Marfiani, Erika; Izzah, Zamrotul; Rosyid, Alfian Nur; Wulaningrum, Prastuti Asta; Setiawan, Herley Windo

doi:10.21203/rs.3.rs-36153/v1

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…A recent study demonstrated treatment for COVID-19 infection using HSCs. The study suggested that the mechanism of HSC to eliminate viruses is by reducing inflammatory cytokines and by increasing anti-inflammatory cytokines that make the virus inactive (Frias-Staheli et al, 2014;Purwati Sumorejo et al, 2020).…”

Section: Immunohistochemical Study Of Liver Tissuementioning

confidence: 99%

Stem Cell Therapy in Dengue Virus-Infected BALB/C Mice Improves Hepatic Injury

Sakinah

Priya

Mok

et al. 2021

Front. Cell Dev. Biol.

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Extensive clinical efforts have been made to control the severity of dengue diseases; however, the dengue morbidity and mortality have not declined. Dengue virus (DENV) can infect and cause systemic damage in many organs, resulting in organ failure. Here, we present a novel report showing a tailored stem-cell-based therapy that can aid in viral clearance and rescue liver cells from further damage during dengue infection. We administered a combination of hematopoietic stem cells and endothelial progenitor cells in a DENV-infected BALB/c mouse model and found that delivery of this cell cocktail had improved their liver functions, confirmed by hematology, histopathology, and next-generation sequencing. These stem and progenitor cells can differentiate into target cells and repair the damaged tissues. In addition, the regime can regulate endothelial proliferation and permeability, modulate inflammatory reactions, enhance extracellular matrix production and angiogenesis, and secrete an array of growth factors to create an enhanced milieu for cell reparation. No previous study has been published on the treatment of dengue infection using stem cells combination. In conclusion, dengue-induced liver damage was rescued by administration of stem cell therapy, with less apoptosis and improved repair and regeneration in the dengue mouse model.

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Section: Immunohistochemical Study Of Liver Tissuementioning

confidence: 99%

Stem Cell Therapy in Dengue Virus-Infected BALB/C Mice Improves Hepatic Injury

Sakinah

Priya

Mok

et al. 2021

Front. Cell Dev. Biol.

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Spotlight on the impact of viral infections on Hematopoietic Stem Cells (HSCs) with a focus on COVID-19 effects

Nasiri

Mohammadzadehsaliani²,

Kheradjoo³

et al. 2023

Cell Commun Signal

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Hematopoietic stem cells (HSCs) are known for their significant capability to reconstitute and preserve a functional hematopoietic system in long-term periods after transplantation into conditioned hosts. HSCs are thus crucial cellular targets for the continual repair of inherited hematologic, metabolic, and immunologic disorders. In addition, HSCs can undergo various fates, such as apoptosis, quiescence, migration, differentiation, and self-renewal. Viruses continuously pose a remarkable health risk and request an appropriate, balanced reaction from our immune system, which as well as affects the bone marrow (BM). Therefore, disruption of the hematopoietic system due to viral infection is essential. In addition, patients for whom the risk-to-benefit ratio of HSC transplantation (HSCT) is acceptable have seen an increase in the use of HSCT in recent years. Hematopoietic suppression, BM failure, and HSC exhaustion are all linked to chronic viral infections. Virus infections continue to be a leading cause of morbidity and mortality in HSCT recipients, despite recent advancements in the field. Furthermore, whereas COVID-19 manifests initially as an infection of the respiratory tract, it is now understood to be a systemic illness that significantly impacts the hematological system. Patients with advanced COVID-19 often have thrombocytopenia and blood hypercoagulability. In the era of COVID-19, Hematological manifestations of COVID-19 (i.e., thrombocytopenia and lymphopenia), the immune response, and HSCT may all be affected by the SARS-CoV-2 virus in various ways. Therefore, it is important to determine whether exposure to viral infections may affect HSCs used for HSCT, as this, in turn, may affect engraftment efficiency. In this article, we reviewed the features of HSCs, and the effects of viral infections on HSCs and HSCT, such as SARS-CoV-2, HIV, cytomegalovirus, Epstein-Barr virus, HIV, etc.

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The Potential of Hematopoietic Stem Cells (Hsc) Against Sars-Cov-2 (Covid-19) With Virus Isolates From Indonesia (In Vitro Study)

Cited by 2 publications

References 3 publications

Stem Cell Therapy in Dengue Virus-Infected BALB/C Mice Improves Hepatic Injury

Stem Cell Therapy in Dengue Virus-Infected BALB/C Mice Improves Hepatic Injury

Spotlight on the impact of viral infections on Hematopoietic Stem Cells (HSCs) with a focus on COVID-19 effects

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