The Potential of a Nanostructured Titanium Oxide Layer with Self-Assembled Monolayers for Biomedical Applications: Surface Properties and Biomechanical Behaviors

Abstract

This study investigated the surface properties and biomechanical behaviors of a nanostructured titanium oxide (TiO) layer with different self-assembled monolayers (SAMs) of phosphonate on the surface of microscope slides. The surface properties of SAMs were analyzed using scanning electron microscopy, X-ray photoemission spectroscopy, and contact angle goniometry. Biomechanical behaviors were evaluated using nanoindentation with a diamond Berkovich indenter. Analytical results indicated that the homogenous nanostructured TiO surface was formed on the substrate surface after the plasma oxidation treatment. As the TiO surface was immersed with 11-phosphonoundecanoic acid solution (PUA-SAM/TiO), the formation of a uniform SAM can be observed on the sample surface. Moreover, the binding energy of O 1s demonstrated the presence of the bisphosphonate monolayer on the SAMs-coated samples. It was also found that the PUA-SAM/TiO sample not only possessed a higher wettability performance, but also exhibited low surface contact stiffness. A SAM surface with a high wettability and low contact stiffness could potentially promote biocompatibility and prevent the formation of a stress shielding effect. Therefore, the self-assembled technology is a promising approach that can be applied to the surface modification of biomedical implants for facilitating bone healing and osseointegration.

Effectiveness of Biofunctionalization of Titanium Surfaces with Phosphonic Acid

“…This can influence cellular behavior such as proliferation, adhesion, and migration, and thereby promote osseointegration and tissue healing following dental implant placement [24]. A study conducted by Lan et al [25] observed the water contact angles and the surface wettability characteristics of a TiO 2 -modified surface with four types of phosphonic acid compounds, along with the control. It was found that the TiO 2 surface treated with 11-phosphonoundecanoic acid (PUA) had the best hydrophilic surface, with an average contact angle measurement of 68.8 ± 0.7.…”

Biosensors for the detection of respiratory viruses: A review

“…Moreover, biosensors are been increasingly applied in clinical analysis due to their portability and point of care testing, which can analyze real biological samples in routine clinical use [25] . The incorporation of nanotechnology in the design of biosensors has improved the detection of biological specimens, as the preparation of biointerfaces of self-assembled monolayers (SAMs), improving biocompatibility and resistance against nonspecific adsorption [26] , [27] , [28] , [29] .…”

An Overview of RNA-Based Scaffolds for Osteogenesis

“…There are various material approaches that can be used to add bioactivity to bulk materials. Broadly, these are changes in the chemistry (Trino et al, 2018), stiffness (Behaviors et al, 2020) and topography (Hasan et al, 2017;Damiati et al, 2018;Behaviors et al, 2020). Different scaffolds have been utilized to facilitate the delivery of RNA, such as polymers-based scaffolds, ceramic-based scaffolds, and metal-based scaffolds.…”