Biosensors for the detection of respiratory viruses: A review

Ribeiro, Brayan Viana; Cordeiro, Taís Aparecida Reis; Freitas, Guilherme Ramos Oliveira e; Ferreira, Lucas Franco; Franco, Diego Leoni

doi:10.1016/j.talo.2020.100007

Cited by 104 publications

(64 citation statements)

References 178 publications

(168 reference statements)

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“…Apart from asymptomatic patients, COVID-19 patients have a large variety of symptoms, leading to the difficulty to determine the infection [ 6 ]. Undoubtedly, researchers need to explore fast, accurate, and cost-effective approaches, such as biosensors, to detect viruses [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Advances in emergent biological recognition elements and bioelectronics for diagnosing COVID-19

et al. 2021

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Coronaviruses pose a serious threat to public health. Tremendous efforts are dedicated to advance reliable and effective detection of coronaviruses. Currently, the coronavirus disease 2019 (COVID-19) diagnosis mainly relies on the detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genetic materials by using reverse transcription-polymerase chain reaction (RT-PCR) assay. However, simpler and more rapid and reliable alternatives are needed to meet high demand during the pandemic. Biosensor-based diagnosis approaches become alternatives for selectively and rapidly detecting virus particles because of their biorecognition elements consisting of biomaterials that are specific to virus biomarkers. Here, we summarize biorecognition materials, including antibodies and antibody-like molecules, that are designed to recognize SARS-CoV-2 biomarkers and the advances of recently developed biosensors for COVID-19 diagnosis. The design of biorecognition materials or layers is crucial to maximize biosensing performances, such as high selectivity and sensitivity of virus detection. Additionally, the recent representative achievements in developing bioelectronics for sensing coronavirus are included. This review includes scholarly articles, mainly published in 2020 and early 2021. In addition to capturing the fast development in the fields of applied materials and biodiagnosis, the outlook of this rapidly evolving technology is summarized. Early diagnosis of COVID-19 could help prevent the spread of this contagious disease and provide significant information to medical teams to treat patients.

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Section: Introductionmentioning

confidence: 99%

Advances in emergent biological recognition elements and bioelectronics for diagnosing COVID-19

et al. 2021

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“…Nanobiosensors are important tools for efficient detection of severe acute respiratory syndrome and other diseases that cause pandemics [ 96 , 97 , 98 , 99 , 100 , 101 ]. For virus detection, depending on the detection mode and measurable properties, nanosensors can be classified into different classes, such as electrical, chemical, electrochemical, optical, piezoelectric [ 102 ], thermal [ 103 , 104 ], magnetic [ 105 ], and biological detection [ 57 ].…”

Section: Nanobiosensors For the Detection Of Human Coronavirus (20mentioning

confidence: 99%

Nanobiosensors for the Detection of Novel Coronavirus 2019-nCoV and Other Pandemic/Epidemic Respiratory Viruses: A Review

Alhalaili

Popescu

Kamoun

et al. 2020

Sensors

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The coronavirus disease 2019 (COVID-19) pandemic is considered a public health emergency of international concern. The 2019 novel coronavirus (2019-nCoV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused this pandemic has spread rapidly to over 200 countries, and has drastically affected public health and the economies of states at unprecedented levels. In this context, efforts around the world are focusing on solving this problem in several directions of research, by: (i) exploring the origin and evolution of the phylogeny of the SARS-CoV-2 viral genome; (ii) developing nanobiosensors that could be highly effective in detecting the new coronavirus; (iii) finding effective treatments for COVID-19; and (iv) working on vaccine development. In this paper, an overview of the progress made in the development of nanobiosensors for the detection of human coronaviruses (SARS-CoV, SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV) is presented, along with specific techniques for modifying the surface of nanobiosensors. The newest detection methods of the influenza virus responsible for acute respiratory syndrome were compared with conventional methods, highlighting the newest trends in diagnostics, applications, and challenges of SARS-CoV-2 (COVID-19 causative virus) nanobiosensors.

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“…Additionally, it has a non-destructive impact on analyzed samples, low current demand, and high sensitivities of sensor performance [ 21 , 22 ]. EIS is commonly used for the detection of other respiratory viruses, like influenza [ 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Immunosensors Based on Screen-Printed Gold and Glassy Carbon Electrodes: Comparison of Performance for Respiratory Syncytial Virus Detection

Białobrzeska¹,

Firganek²,

Czerkies

et al. 2020

Biosensors

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This paper presents the development and comparison of label-free electrochemical immunosensors based on screen-printed gold and glassy carbon (GC) disc electrodes for efficient and rapid detection of respiratory syncytial virus (RSV). Briefly, the antibody specific to the F protein of RSV was successfully immobilized on modified electrodes. Antibody coupling on the Au surface was conducted via 4-aminothiophenol (4-ATP) and glutaraldehyde (GA). The GC surface was modified with poly-L-lysine (PLL) for direct anti-RSV conjugation after EDC/NHS (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-Hydroxysuccinimide) activation. Electrochemical characterizations of the immunosensors were carried out by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). GC-based immunosensors show a dynamic range of antigen detection from 1.0 × 105 PFU/mL to 1.5×107 PFU/mL, more than 1.0 × 105 PFU/mL to 1.0 × 107 PFU/mL for the Au-based sensor. However, the GC platform is less sensitive and shows a higher detection limit (LOD) for RSV. The limit of detection of the Au immunosensor is 1.1 × 103 PFU/mL, three orders of magnitude lower than 2.85 × 106 PFU/mL for GC. Thus, the Au-based immunosensor has better analytical performance for virus detection than a carbon-based platform due to high sensitivity and very low RSV detection, obtained with good reproducibility.

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Biosensors for the detection of respiratory viruses: A review

Cited by 104 publications

References 178 publications

Advances in emergent biological recognition elements and bioelectronics for diagnosing COVID-19

Advances in emergent biological recognition elements and bioelectronics for diagnosing COVID-19

Nanobiosensors for the Detection of Novel Coronavirus 2019-nCoV and Other Pandemic/Epidemic Respiratory Viruses: A Review

Electrochemical Immunosensors Based on Screen-Printed Gold and Glassy Carbon Electrodes: Comparison of Performance for Respiratory Syncytial Virus Detection

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