Nanobiosensors for the Detection of Novel Coronavirus 2019-nCoV and Other Pandemic/Epidemic Respiratory Viruses: A Review

Alhalaili, Badriyah; Popescu, Ileana Nicoleta; Kamoun, Olfa; Alzubi, Feras; Alawadhia, Sami; Vidu, Ruxandra

doi:10.3390/s20226591

Cited by 42 publications

(31 citation statements)

References 243 publications

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“…Although serology-based tests and reverse transcription-polymerase chain reaction (RT-PCR) are routinely used for the detection of COVID-19, there is a need for accuracy and rapidity in diagnosis that can be fulfilled by the use of ultrasensitive nanobiosensors that play a major role in the detection of novel coronavirus. Nanobiosensors provide a rapid, cost-effective, accurate, and miniaturized platform for the detection of SARS-CoV-2 [ 29 ].…”

Section: State-of-the-art Of Nanomaterials As Anti-sars-cov-2mentioning

confidence: 99%

Nanotechnology as a Shield against COVID-19: Current Advancement and Limitations

Rai

Bonde

Yadav

et al. 2021

Viruses

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The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health problem that the WHO declared a pandemic. COVID-19 has resulted in a worldwide lockdown and threatened to topple the global economy. The mortality of COVID-19 is comparatively low compared with previous SARS outbreaks, but the rate of spread of the disease and its morbidity is alarming. This virus can be transmitted human-to-human through droplets and close contact, and people of all ages are susceptible to this virus. With the advancements in nanotechnology, their remarkable properties, including their ability to amplify signal, can be used for the development of nanobiosensors and nanoimaging techniques that can be used for early-stage detection along with other diagnostic tools. Nano-based protection equipment and disinfecting agents can provide much-needed protection against SARS-CoV-2. Moreover, nanoparticles can serve as a carrier for antigens or as an adjuvant, thereby making way for the development of a new generation of vaccines. The present review elaborates the role of nanotechnology-based tactics used for the detection, diagnosis, protection, and treatment of COVID-19 caused by the SARS-CoV-2 virus.

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Section: State-of-the-art Of Nanomaterials As Anti-sars-cov-2mentioning

confidence: 99%

Nanotechnology as a Shield against COVID-19: Current Advancement and Limitations

Rai

Bonde

Yadav

et al. 2021

Viruses

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“…The ACE2 receptor is found in many organs throughout the human body and can perhaps provide a link as to why the virus can spread to other organs besides the lungs [57]. Table 1 summarizes inflammatory biomarkers levels detected in adult patients with COVID-19 [58]. 0.0-7.0 (pg/mL) 7.9 (pg/mL) D-Dimer 0-0.243 (µg/mL) 0.5 (µg/mL) Serum Amyloid A (SAA) 0-10 (mg/mL) 108.4 (mg/mL)…”

Section: Biomarker Progression In the Human Bodymentioning

confidence: 99%

COVID-19 Biomarkers and Advanced Sensing Technologies for Point-of-Care (POC) Diagnosis

et al. 2021

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COVID-19, also known as SARS-CoV-2 is a novel, respiratory virus currently plaguing humanity. Genetically, at its core, it is a single-strand positive-sense RNA virus. It is a beta-type Coronavirus and is distinct in its structure and binding mechanism compared to other types of coronaviruses. Testing for the virus remains a challenge due to the small market available for at-home detection. Currently, there are three main types of tests for biomarker detection: viral, antigen and antibody. Reverse Transcription-Polymerase Chain Reaction (RT-PCR) remains the gold standard for viral testing. However, the lack of quantitative detection and turnaround time for results are drawbacks. This manuscript focuses on recent advances in COVID-19 detection that have lower limits of detection and faster response times than RT-PCR testing. The advancements in sensing platforms have amplified the detection levels and provided real-time results for SARS-CoV-2 spike protein detection with limits as low as 1 fg/mL in the Graphene Field Effect Transistor (FET) sensor. Additionally, using multiple biomarkers, detection levels can achieve a specificity and sensitivity level comparable to that of PCR testing. Proper biomarker selection coupled with nano sensing detection platforms are key in the widespread use of Point of Care (POC) diagnosis in COVID-19 detection.

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“…Nano-biosensors are crucial tools for specific and fast detection. A sensor was developed by coupling clustered regularly interspaced short palindromic repeats (CRISPR)-Chip with a graphene-based field effect transistor (FET) [ 78 ]. This coupled biosensor does not need amplification and detects DNA and RNA at very low concentrations with swift response.…”

Section: Biosensors For Covid-19mentioning

confidence: 99%

Critical neurological features of COVID-19: Role of imaging methods and biosensors for effective diagnosis

Singh¹,

Allawadhi²,

Khurana³

et al. 2021

Sensors International

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COVID-19 is a respiratory infection that has been declared as a global health crisis by the WHO. It mainly affects the respiratory system. Apart from respiratory system, it also affects other organs as well including the brain. Numerous emerging reports have demonstrated that the COVID-19 has detrimental effects on neurological functions, and can lead to severe impairment of the nervous system. The neurological manifestations linked with COVID-19 include headache, anosmia, encephalitis, epileptic seizures, Guillain-Barre syndrome, stroke and intracerebral hemorrhage alongwith multiple others complications. The CNS related complications may be severe are they are linked with poor diagnosis which may worsen the condition. Therefore, there is a need to precisely understand the neurological sequelae along with upcoming clinical outcomes. Here, we presented a brief review of neurological complications and symptoms associated with COVID-19 along with brain imaging findings. Further, we have discussed about the emerging biosensing approaches which may aid in rapid, precise and mass diagnosis of COVID-19.

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Nanobiosensors for the Detection of Novel Coronavirus 2019-nCoV and Other Pandemic/Epidemic Respiratory Viruses: A Review

Cited by 42 publications

References 243 publications

Nanotechnology as a Shield against COVID-19: Current Advancement and Limitations

Nanotechnology as a Shield against COVID-19: Current Advancement and Limitations

COVID-19 Biomarkers and Advanced Sensing Technologies for Point-of-Care (POC) Diagnosis

Critical neurological features of COVID-19: Role of imaging methods and biosensors for effective diagnosis

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