The potential impact of the preparation rich in growth factors (PRGF) in different medical fields☆

Platelet Concentrates: Past, Present and Future

“…Additional randomized, controlled clinical trials are warranted to test the long term benefits and ultimate surgical outcomes associated with PRP and FS [2,17]. As with PRF, though this biomaterial appears to accelerate physiologic healing, the numerous perspectives of PRF have still to be clinically tested [1].…”

“…The scientific rationale behind the use of these preparations lies in the fact that growth factors (GFs) are known to play a crucial role in hard and soft tissue repair mechanisms [13][14][15][16]. These GFs exhibit chemotactic and mitogenic properties that promote and modulate cellular functions involved in tissue healing, regeneration and cell proliferation [17].…”

Overview and Future of Hemo-Components and Natural Guided Regeneration

“…PRF products cannot be used as injectable products in sports medicine for example [12,17]. Some groups advocated that the presence of leukocytes may be negative for the therapeutic outcome, due to a potential risk of stimulation of the inflammatory process after the membrane placement in a wounded site [18]. Other researchers insisted on the need of some leukocyte population in the injectable PRP in order to increase the growth factors production, the release of anti-pain mediators and the natural anti-infectious activity.…”

Updates in biological therapies for knee injuries: anterior cruciate ligament

“…The primary focus of this article are biological solutions for biological problems that lead to less invasive procedures, accelerated and enhanced healing, reduced morbidity, and optimized recovery [7].…”