The Potential Impact of Chikungunya Virus Outbreaks on Blood Transfusion

Appassakij, Hatsadee; Silpapojakul, Khachornsakdi; Promwong, Charuporn; Rujirojindakul, Pairaya

doi:10.1016/j.tmrv.2019.06.002

Cited by 8 publications

(12 citation statements)

References 55 publications

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“…The literature indicates an increased risk for development of severe symptoms in neonates if mother is under viremia period during the childbirth but this risk softens if the infection occurs at least 4 weeks prior to birth (Robillard et al, 2006;Farias et al, 2019). Appassakij et al (2020) reported that individuals infected with CHIKV can also be potential disease spreaders through blood transfusions or transplants, especially during an outbreak period. This event was observed during the outbreaks occurred in La Reunion, Italy, Thailand, and Puerto Rico.…”

Section: Epidemiology and Transmissionmentioning

confidence: 99%

“…The prevalence of CHIKV RNA in blood donations ranged from approximately 0.4-2.1% during the epidemics. Therefore, an extra care should be taken during the transfusion processes in places where CHIKV is endemic or when outbreaks are ongoing (Petersen et al, 2010;Appassakij et al, 2013Appassakij et al, , 2020Petersen and Epstein, 2014;Stanley et al, 2021).…”

Section: Epidemiology and Transmissionmentioning

confidence: 99%

See 1 more Smart Citation

Overview on Chikungunya Virus Infection: From Epidemiology to State-of-the-Art Experimental Models

Constant

Rajsfus²,

Carneiro³

et al. 2021

Front. Microbiol.

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Chikungunya virus (CHIKV) is currently one of the most relevant arboviruses to public health. It is a member of the Togaviridae family and alphavirus genus and causes an arthritogenic disease known as chikungunya fever (CHIKF). It is characterized by a multifaceted disease, which is distinguished from other arbovirus infections by the intense and debilitating arthralgia that can last for months or years in some individuals. Despite the great social and economic burden caused by CHIKV infection, there is no vaccine or specific antiviral drugs currently available. Recent outbreaks have shown a change in the severity profile of the disease in which atypical and severe manifestation lead to hundreds of deaths, reinforcing the necessity to understand the replication and pathogenesis processes. CHIKF is a complex disease resultant from the infection of a plethora of cell types. Although there are several in vivo models for studying CHIKV infection, none of them reproduces integrally the disease signature observed in humans, which is a challenge for vaccine and drug development. Therefore, understanding the potentials and limitations of the state-of-the-art experimental models is imperative to advance in the field. In this context, the present review outlines the present knowledge on CHIKV epidemiology, replication, pathogenesis, and immunity and also brings a critical perspective on the current in vitro and in vivo state-of-the-art experimental models of CHIKF.

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Section: Epidemiology and Transmissionmentioning

confidence: 99%

Section: Epidemiology and Transmissionmentioning

confidence: 99%

Overview on Chikungunya Virus Infection: From Epidemiology to State-of-the-Art Experimental Models

Constant

Rajsfus²,

Carneiro³

et al. 2021

Front. Microbiol.

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“…Similarly, there has been long‐term and ongoing CHIKV activity in multiple countries in Asia 57,58 . In Thailand, there have been periodic CHIKV outbreaks particularly in the southern part of the country, including outbreaks in 2009 and 2019, 22,59 with 11 484 cases reported in 2019, during the time of the study 48 . Appassakij estimated the risk of TT‐CHIKV to be approximately 1 in 2000 during the 2009 outbreak.…”

Section: Discussionmentioning

confidence: 99%

Detection of dengue, chikungunya, and Zika RNA in blood donors from Southeast Asia

Stanley

Chongkolwatana

Duong³

et al. 2020

Transfusion

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Background Chikungunya (CHIKV), dengue (DENV), and Zika (ZIKV) viruses are of concern due to the potential of transfusion transmission in blood, especially in regions such as Southeast Asia where the viruses are endemic. The recent availability of nucleic acid testing (NAT) to screen blood donations on an automated platform provides the opportunity to detect potentially infectious units in asymptomatic donors. Study Design and Methods Three thousand blood donations from Vietnam and 6000 from Thailand were screened with a real‐time polymerase chain reaction (PCR) test (cobas CHIKV/DENV, Roche Diagnostics, Indianapolis, IN) and equal numbers on cobas Zika (Roche Diagnostics). Reactive samples were tested by alternative NAT with resolution of discordant results by heminested PCR. Throughput of simultaneous testing of the two assays on the cobas 8800 system (Roche Diagnostics) was evaluated. Results In Vietnam, 9 of 3045 samples were reactive for DENV and all were confirmed, for a prevalence (with 95% confidence interval [CI]) of 0.296% (0.135‐0.560). In Thailand, 2 of 6000 samples were reactive for CHIKV, 4 of 6000 for DENV, and 1 of 6005 for ZIKV, and all confirmed. The prevalence of CHIKV is 0.033% (0.004‐0.120), DENV 0.067% (0.018‐0.171), and ZIKV 0.017% (0.000‐0.093). The overall specificity for the cobas CHIKV/DENV and cobas Zika tests was 100% (99.959‐100). For the simultaneous assay testing, 960 test results were available in 7 hours and 53 minutes. Conclusion Detection of CHIKV, DENV, and ZIKV RNA in donor samples in Vietnam and Thailand indicate the presence of the virus in asymptomatic blood donors. The cobas 6800/8800 systems (Roche Molecular Systems, Pleasanton, CA) enable screening blood donations in endemic areas for these viruses together or separately.

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“…CHIKV, which is popularly characterized by acute and chronic joint inflammatory manifestations, is responsible for large periodic epidemics in endemic and non-endemic areas where competent mosquitoes are present. Transmission of CHIKV by transfusion during outbreaks of explosives has never been documented, and the true impact of CHIKV infection on blood transfusion during an outbreak is unknown (APPASSAKIJ H et al, 2019;BRASIL, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Palavras-chave: Artrite, Pediatria, Chikungunya Vírus 1. Faculdade Santa Maria (FSM), Cajazeiras -PB.…”

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Clinical manifestations of chikungunya infection in the pediatric population: systematic review

Silva¹,

Silva²,

Júnior³

et al. 2019

Acervo Saúde

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Objective: To describe the clinical manifestations, especially those related to rheumatology, in the infant and neonatal population with Chikungunya viral, which are described in case studies in the literature. Methods: This is about a systematic review study, conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) methodology. In order to identify the articles about the subject, the databases indexed to the BVS and SCIELO were searched, from June to July 2019, with the following search strategy: chikungunya virus and arthritis, arthralgia rheumatoid and chikungynya fever and arboviruses and arthralgia. Filters used included articles in English that have been published in the last 5 years. Manual searches were made in the bibliographic references of the articles found. Results: Six articles were reviewed, which addressed cases of Chikungunya confirmed pediatric patients. It was noticed that the main clinical manifestations were: fever, cutaneous symptoms, irritability and vomiting. Regarding rheumatologic symptoms, it was concluded that arthralgia and arthritis are uncommon in these patients, and residual arthritis is much less frequent in this age group. Conclusion: The control of the symptomatology and the dissemination of information related to the transmission of the virus helps in the promotion of health, and the complications of the disease must be known in time to be minimized.

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The Potential Impact of Chikungunya Virus Outbreaks on Blood Transfusion

Cited by 8 publications

References 55 publications

Overview on Chikungunya Virus Infection: From Epidemiology to State-of-the-Art Experimental Models

Overview on Chikungunya Virus Infection: From Epidemiology to State-of-the-Art Experimental Models

Detection of dengue, chikungunya, and Zika RNA in blood donors from Southeast Asia

Clinical manifestations of chikungunya infection in the pediatric population: systematic review

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