The possible role of zinc in the etiopathogenesis of endometriosis

Em, Messalli; Mt, Schettino; Mainini, G; Ercolano, S Di Capua; Fuschillo, Giacomo; Falcone, Francesca; Espósito, Evangelina; Donna, Mariano Catello Di; Franciscis, Pasquale De; Torella, Annalaura

doi:10.12891/ceog19332014

Cited by 17 publications

(11 citation statements)

References 29 publications

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“…In addition, there are studies directly examining the role of Zn in patients with endometriosis, which also constitute an important source of knowledge. In the studies by Messala et al and Lai et al, the authors compared blood zinc level measurements in women with endometriosis and healthy control women [ 98 , 99 ]. Both authors found lower serum zinc concentrations in patients with endometriosis compared to the control group, by 22% [ 98 ] and 43% [ 99 ], respectively.…”

Section: The Role Of Selected Dietary Components In the Course Of End...mentioning

confidence: 99%

“…In the studies by Messala et al and Lai et al, the authors compared blood zinc level measurements in women with endometriosis and healthy control women [ 98 , 99 ]. Both authors found lower serum zinc concentrations in patients with endometriosis compared to the control group, by 22% [ 98 ] and 43% [ 99 ], respectively. Zinc levels were also lower in the follicular fluid of patients with endometriosis compared to those with tubal infertility.…”

Section: The Role Of Selected Dietary Components In the Course Of End...mentioning

confidence: 99%

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How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

Abramiuk,

Mertowska,

Frankowska

et al. 2024

Nutrients

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Endometriosis is a chronic, hormone-dependent disease characterized by the presence of endometrial tissue in ectopic locations. Since the treatment options for this disease are still limited, and the cure rate is unsatisfactory, the search for ways to treat symptoms and modify the course of the disease is of key importance in improving the quality of life of patients with endometriosis. So far, the literature has shown that nutrition can influence endometriosis through hormonal modification and altering the inflammatory or oxidative response. Since the importance of nutrition in this disease is still a subject of scientific research, we aimed to summarize the current knowledge on the role of dietary modifications in endometriosis. Our review showed that nutrients with anti-inflammatory and antioxidant properties, including most vitamins and several trace elements, may influence the pathogenesis of endometriosis and can be considered as the nutrients preventing the development of endometriosis. However, despite the many discoveries described in this review, further interdisciplinary research on this topic seems to be extremely important, as in the future, it may result in the development of personalized therapies supporting the treatment of endometriosis.

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Section: The Role Of Selected Dietary Components In the Course Of End...mentioning

confidence: 99%

Section: The Role Of Selected Dietary Components In the Course Of End...mentioning

confidence: 99%

How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

Abramiuk,

Mertowska,

Frankowska

et al. 2024

Nutrients

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“…They may decrease the expression of IGF-1, TGF-β, TNFα, and IL-6 [ 141 ]. A possible role of zinc deficiency, a micronutrient with important functions in the body—regulation of cell growth, hormone release, and immune response—in the etiopathogenesis of endometriosis has also been described [ 142 ]. In a group of 42 patients with endometriosis, the average serum zinc concentration was 1010 ± 59.24 µg L −1 , while in 44 healthy women, the level of this micronutrient was slightly higher (1294 ± 62.22 µg L −1 ) [ 142 ].…”

Section: Micronutrientsmentioning

confidence: 99%

The Role of Selected Dietary Factors in the Development and Course of Endometriosis

et al. 2023

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Endometriosis is a chronic disease with a complex, heterogeneous pathogenesis that affects about 10% of women of reproductive age, causing pain and leading to infertility. Treatment consists of administering pharmacological agents (resulting in a reduction of estrogen levels and inflammation), as well as the surgical removal of endometriotic lesions. Unfortunately, despite a wide range of available therapies, there is still a high recurrence rate after surgery. Consequently, it is necessary to improve the outcome of patients with endometriosis. In this context, there is growing interest in possible dietary modification to support or complement classic treatment options and even serve as a potential alternative to hormone therapy. In addition, a growing number of studies indicate positive effects of selected dietary factors on the development and course of endometriosis. This review article focuses on the potentially beneficial effects of compounds from the polyphenol group (curcumin, epigallocatechin gallate, quercetin, resveratrol), vitamins, and selected micronutrients on endometriosis. The results indicate the potential of the selected ingredients in fighting the disease. However, most of the studies have been performed on experimental animal models, with a smaller proportion looking at the actual effects of use among women. Therefore, well-designed studies are needed to assess the importance of a well-chosen diet and the effects of specific dietary factors on the health of women suffering from endometriosis.

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“…Microbiota and associated factors seem important for the G-E origin and the growth of endometriosis [ 6 ]. This could explain the effect of food intake [ 28 , 29 , 30 ] and exercise [ 31 , 32 , 33 , 34 , 35 , 36 , 37 ] on endometriosis and of food supplements such as berberine [ 38 , 39 ], NAC [ 40 ], zinc [ 36 , 37 ] and gluten-free diet [ 41 ].…”

Section: New Understanding Of Pathophysiologymentioning

confidence: 99%

New Understanding of Diagnosis, Treatment and Prevention of Endometriosis

Amro

Aristondo

Al-Suwaidi

et al. 2022

IJERPH

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For 100 years, pelvic endometriosis has been considered to originate from the implantation of endometrial cells following retrograde menstruation or metaplasia. Since some observations, such as the clonal aspect, the biochemical variability of lesions and endometriosis in women without endometrium, the genetic-epigenetic (G-E) theory describes that endometriosis only begins after a series of cumulative G-E cellular changes. This explains that the endometriotic may originate from any pluripotent cell apart from the endometrium, that ‘endometrium-like cells’ can harbour important G-E differences, and that the risk is higher in predisposed women with more inherited incidents. A consequence is a high risk after puberty which decreases progressively thereafter. Considering a 10-year delay between initiation and performing a laparoscopy, this was observed in the United Arab Emirates, Belgium, France and USA. The subsequent growth varies with the G-E changes and the environment but is self-limiting probably because of the immunologic reaction and fibrosis. That each lesion has a different set of G-E incidents explains the variability of pain and the response to hormonal treatment. New lesions may develop, but recurrences after surgical excision are rare. The fibrosis around endometriosis belongs to the body and does not need to be removed. This suggests conservative excision or minimal bowel without safety margins and superficial treatment of ovarian endometriosis. This G-E concept also suggests prevention by decreasing oxidative stress from retrograde menstruation or the peritoneal microbiome. This suggests the prevention of vaginal infections and changes in the gastrointestinal microbiota through food intake and exercise. In conclusion, a higher risk of initiating endometriosis during adolescence was observed in UAE, France, Belgium and USA. This new understanding and the limited growth opens perspectives for earlier diagnosis and better treatment.

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The possible role of zinc in the etiopathogenesis of endometriosis

Abstract: Materials and MethodsAfter obtaining their informed consent, the authors selected 42 patients whose histodiagnosis had revealed pelvic endometriosis and gathered them at the general practice for gynaecology and obstetrics and/or sterility of the

Cited by 17 publications

References 29 publications

How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

The Role of Selected Dietary Factors in the Development and Course of Endometriosis

New Understanding of Diagnosis, Treatment and Prevention of Endometriosis

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