The Role of Selected Dietary Factors in the Development and Course of Endometriosis

Abstract

Endometriosis is a chronic disease with a complex, heterogeneous pathogenesis that affects about 10% of women of reproductive age, causing pain and leading to infertility. Treatment consists of administering pharmacological agents (resulting in a reduction of estrogen levels and inflammation), as well as the surgical removal of endometriotic lesions. Unfortunately, despite a wide range of available therapies, there is still a high recurrence rate after surgery. Consequently, it is necessary to improve the outcome of patients with endometriosis. In this context, there is growing interest in possible dietary modification to support or complement classic treatment options and even serve as a potential alternative to hormone therapy. In addition, a growing number of studies indicate positive effects of selected dietary factors on the development and course of endometriosis. This review article focuses on the potentially beneficial effects of compounds from the polyphenol group (curcumin, epigallocatechin gallate, quercetin, resveratrol), vitamins, and selected micronutrients on endometriosis. The results indicate the potential of the selected ingredients in fighting the disease. However, most of the studies have been performed on experimental animal models, with a smaller proportion looking at the actual effects of use among women. Therefore, well-designed studies are needed to assess the importance of a well-chosen diet and the effects of specific dietary factors on the health of women suffering from endometriosis.

How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

“…Macroelements, also known as macrominerals, play significant roles in the overall health and well-being of individuals, and they can have specific impacts on the course of endometriosis [ 77 , 78 , 79 , 80 ]. These elements, required in larger amounts by the body, include calcium, magnesium, sodium, potassium, chloride, phosphorus, and sulfur.…”

“… The importance of selected macroelements in the course of endometriosis; based on [ 77 , 78 , 79 , 80 ]. …”

Molecular Mechanism of Resveratrol and Its Therapeutic Potential on Female Infertility

“…Numerous publications regarding the effect of resveratrol on infertility-related conditions have been published: for instance, there are studies exploring the role of resveratrol on endometriosis [27][28][29], PCOS [30,31], and infertility [32]. Nonetheless, as female infertility can be due to many causes, more studies are needed to overview the potential positive or negative effect of resveratrol on different female infertility-related conditions.…”