The Possible Biological Function of Pseudo-cholinesterase

Clitherow, J. W.; Mitchard, M.; Harper, Nicola

doi:10.1038/1991000a0

Cited by 84 publications

(27 citation statements)

References 6 publications

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“…It is possible to propose that the variation in BChE activity may be a conse quence of weight in CHE2 C5-and faint CHE2 C5+ phenotypes. This appears to be in accordance with Clitherow et al [38] who suggested that the principal function of BChE should be to hydrolyze the acylcholine esters that might arise as by-prod ucts of free fatty acid catabolism and lipogenesis in the liver. Thus, in these cases, BChE might be induced by an accelerated turnover of serum lipids and lipoproteins, as suggested by Cucuianu et al [17], Our findings are very clear in terms of the significant lower mean weight shown by individuals with intense C5 bands.…”

Section: Discussionsupporting

confidence: 75%

The C<sub>5</sub> Isozyme of Serum Cholinesterase and Adult Weight

Chautard‐Freire‐Maia¹,

Primo-Parmo²,

Picheth

et al. 1991

Hum Hered

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The relationship between the CHE2 locus of serum cholinesterase (BChE) and adult human weight was studied in a sample of 225 CHE2 C5+ individuals and 225 CHE2 C5- controls matched for sex, height, age and race. With respect to the intensity of the C₅ band staining (scored 1–6), 113 individuals had faint C₅ bands (scores 1–3) and 112 intense C₅ bands (scores 4–6). The individuals with intense CHE2 C5+ phenotype showed a significantly lower mean adult weight (64.66 ± 0.73 kg) when compared to their controls (70.59 ± 0.97 kg) and a significant reduction in weight variance (59.81 and 105.18, respectively). Individuals with faint C₅ bands, although showing a negative correlation between weight and C₅ band intensity, did not differ from their controls in mean weight.

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Section: Discussionsupporting

confidence: 75%

The C<sub>5</sub> Isozyme of Serum Cholinesterase and Adult Weight

Chautard‐Freire‐Maia¹,

Primo-Parmo²,

Picheth

et al. 1991

Hum Hered

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“…However, the half-life of cholinesterase in plasma is about 10 days, and increases in its consumption rate are more important to consider than poor synthesis in acute inflammation of bacteremia. Some reports have suggested a role for serum cholinesterase in lipid metabolism (15), a controlling role in the permeability of membranes (16), and a role in the coregulation of the degradation of acetylcholine (17). It has not been clear whether the serum cholinesterase level decreases rapidly in patients with sepsis.…”

Section: Discussionmentioning

confidence: 99%

Liver function tests in patients with bacteremia

Kanai

Honda

Uehara

et al. 2008

Clinical Laboratory Analysis

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The purpose of this study was to evaluate liver function tests as potential indicators of bacteremia. We examined 156 patients with laboratory‐confirmed bacteremia (bacteremia group) and 211 bacteremia‐negative patients with bacterial infections (control group). The patients of the two groups had no underlying liver diseases. For patients in the bacteremia group, we analyzed liver function tests results obtained the day when the first positive blood culture was ordered. For those in the control group, the same data were obtained on the day when the first of multiple negative blood cultures was ordered. At t‐test analyses, serum levels of gamma‐glutamyl transpeptidase (γ‐GT) and alkaline phosphatase (ALP) were significantly higher, and those of albumin, total cholesterol, and cholinesterase were significantly lower in the bacteremia group than in the control group. Multivariate analyses found serum cholinesterase as an independent factor with adjusted odds ratio of 0.319 (per 65 U/L, standard deviation [SD] size). Serum level of C‐reactive protein (CRP), on the other hand, showed no significant difference between the two groups. Serum levels of γ‐GT, ALP, albumin, total cholesterol, and cholinesterase more rapidly altered when various bacterial infections accompanied bacteremia. Therefore, they may be useful in detecting sepsis in its early stages. J. Clin. Lab. Anal. 22:66–69, 2008. © 2008 Wiley‐Liss, Inc.

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“…Others have suggested a rôle for plasma cholinesterase in lipid metabolism [8] or a regulatory rôle in choline homeostasis [9]. It is known that both cholinesterases are closely associated with membranes across which transport of water and ions take place and there is much evidence to support the cholinesterases as having a controlling rôle in the permeability of membranes.…”

Section: Physiology Of the Cholinesterasesmentioning

confidence: 99%

Cholinesterase Its significance in anaesthetic practice

1997

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SummaryPlasma cholinesterase is an enzyme which has importance to the anaesthetist primarily for its rôle in the metabolism of suxamethonium, although other anaesthetic related drugs that this enzyme metabolises are also increasingly important. In this article we review current thoughts on the function, profile and chemistry of plasma cholinesterase. Causes of variations in the activity of the enzyme are described and the basis of genetic variations is explained.

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The Possible Biological Function of Pseudo-cholinesterase

Cited by 84 publications

References 6 publications

The C<sub>5</sub> Isozyme of Serum Cholinesterase and Adult Weight

The C<sub>5</sub> Isozyme of Serum Cholinesterase and Adult Weight

Liver function tests in patients with bacteremia

Cholinesterase Its significance in anaesthetic practice

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