The C&lt;sub&gt;5&lt;/sub&gt; Isozyme of Serum Cholinesterase and Adult Weight

Chautard‐Freire‐Maia, Eleidi A.; Primo-Parmo, S. L.; Picheth, Geraldo; Lourenço, M. A.; Vieira, Muriel M.

doi:10.1159/000154021

Cited by 28 publications

(34 citation statements)

References 28 publications

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“…The frequency of the CHE2 C5 þ phenotype in the obese individuals ascertained at the Obese Ambulatory (9.52%72.26%) did not differ (w 2 (1) ¼ 0.09; P40.70) from the frequency reported for the general population of Curitiba (10.23%70.60%). 9 In the case of the CHE2 C5 þ obese individuals, 43.8% had ARC 5 of intense phenotype when classified according to the median (7.6%) found in the nonobese control sample. The distributions of the CHE2 C5 þ phenotypes (intense and faint C 5 band) did not differ when obese individuals were compared to nonobese individuals (w 2 (1) ¼ 0.19; P40.60).…”

Section: Discussionmentioning

confidence: 94%

“…With the exclusion of one BCHE UA individual from the 16 CHE2 C5 þ obese individuals (Table 2), mean total BChE activities were 5.8370.97 and It is a well-known fact that the CHE2 C5 þ phenotype presents higher mean BChE total activity than the CHE2 C5À phenotype as shown in samples from different general populations. 5,9,11,[20][21][22] Although this difference between the mean BChE activities of these two phenotypes occurs in the general population, the data in Table 2 show that there was no difference in total mean BChE activity between CHE2 C5 þ and CHE2 C5À obese individuals (t ¼ 0.07; P40.90). In a previous study on CHE2 C5 þ individuals from a population sample, positive correlations between weight and total and AC OF BChE activities were shown.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8][9] A positive association between BMI and the activity of the C 4/5 complex of BChE was also reported. 10 In the case of the CHE2 gene that interacts with the BCHE gene to form the C 5 complex, it was shown that CHE2 C5 þ individuals present a significantly lower mean weight 9 and a significantly lower mean BMI 11 than their CHE2 C5À controls.…”

Section: Introductionmentioning

confidence: 99%

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Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

et al. 2003

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OBJECTIVE:To investigate the association between butyrylcholinesterase (BChE) activities (total and band specific) and body mass index (BMI) in obese and nonobese individuals, considering other variables (anthropometric, biochemical and hormonal) and the leanness process. SUBJECTS: Obese (BMIZ30 kg/m 2 ; N ¼ 181) and nonobese individuals (N ¼ 265), classified according to the CHE2 locus phenotypes, with the obese patients being followed-up when submitted to a weight-loss program. MEASUREMENTS: Anthropometric (weight, height, BMI, waist, waist/hip ratioFWHR, triceps and subscapular skinfolds, percentage of body fat and arterial pressures), hormonal (insulin, estradiolFE 2 , triiodothyronineFT 3 and thyroxineFT 4 ) and biochemical (glucose, total cholesterol, HDL-C, triglycerides, uric acid, urea, creatinine, sodium, potassium and BChE activities) variables. RESULTS: Although obese CHE2 C5À individuals presented higher mean BChE activities than their CHE2 C5À controls and diminished mean activities with leanness, similar comparisons did not show any difference in the CHE2 C5 þ group. Furthermore, the mean serum potassium values of obese individuals were significantly higher in the CHE2 C5 þ than in the CHE2 C5À phenotype. The BChE activities were less related to BMI in obese CHE2 C5À individuals than in their controls. In the CHE2 C5À obese group, significant regression coefficients were found between BChE activity variables and BMI ( þ ), ethnic origin (higher in Euro-Brazilians), sex (higher in males), diastolic pressure (À), triceps skinfold ( þ ), total cholesterol ( þ ), T 3 ( þ ) and E 2 (À). The main findings in the CHE2 C5 þ obese group: mean insulin levels decreased with leanness and a significant correlation was detected between the C 5 complex activity and creatinine ( þ ), insulin (À) and WHR (À); a significantly higher frequency of weight loss occurred compared to the CHE2 C5À group. CONCLUSION: In the present study, different relations between obesity and some of the studied variables were found when CHE2 C5 þ and CHE2 C5À individuals were compared.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

et al. 2003

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“…Sera from CHE2 C5+ individuals showed an approximate 30% increase in mean BChE activity (BChEA) when compared with CHE2 C5-sera (3). CHE2 C5+ phenotype individuals showed lower mean body weight values (2) and lower mean body mass index (BMI) values (4) than noted in the CHE2 C5-phenotype.…”

Section: Introductionmentioning

confidence: 98%

“…In serum, one of the several molecular forms of BChE, the C 5 complex, is formed by association of BChE molecules with a still-unidentified protein, which is codified by the CHE2 locus (1). The presence of C 5 (constituting about 10% of the EuroBrazilian population) characterizes the CHE2 C5+ phenotype (2), and the absence of this complex characterizes the CHE2 C5-phenotype. Sera from CHE2 C5+ individuals showed an approximate 30% increase in mean BChE activity (BChEA) when compared with CHE2 C5-sera (3).…”

Section: Introductionmentioning

confidence: 99%

Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes

Cwiertnia

Alcântara

Réa

et al. 2010

Arq Bras Endocrinol Metab

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Objective: To investigate the relationship between butyrylcholinesterase (BChE) activities (total and band specific) and diabetes mellitus. Subjects and methods: BChE activities (BChEA, AC 4/5 , AC OF and RC 5 ) were analyzed in 101 type 1 (DM1) and in 145 type 2 (DM2) diabetic patients, in relation to phenotype, weight and incidence of metabolic syndrome (MS) in these patients. The C 4/5 and C 5 complex were separated from other molecular forms (C OF ) using an acid agar gel. Results: The BChE activity (BChEA) and the absolute activities of C 4/5 (AC 4/5 ) and C OF (AC OF ) showed a high positive correlation coefficient to weight in the CHE2 C5-group, while the relative activity of C 5 complex (RC 5 ) showed a negative correlation to weight. Conclusions: The present study suggests that the positive correlation of the BChE activities to diabetes mellitus and to insulin resistance may depend on the CHE2 locus variability. High values of BChE activities were associated with insulin resistance only in CHE2 C5-diabetic patients, while in CHE2 C5+ diabetic patients, the presence of C 5 complex, especially in a relatively high proportion, leads to less fat storage and better protection against metabolic syndrome. Arq Bras Endocrinol Metab. 2010;54(1):60-7 Keywords BCHE and CHE2 loci; C 4/5 and C 5 complexes; obesity, insulin resistance; metabolic syndrome; serum cholinesterase RESUMO Objetivo: Investigar a associação entre as atividades (total e banda específica) da butirilcolinesterase (BChE) e diabetes melito. Sujeitos e métodos: As atividades da BChE (BChEA, AC 4/5 , AC OF e RC 5 ) foram analisadas em 101 pacientes diabéticos do tipo 1 (DM1) e 145 do tipo 2 (DM2) em relação aos fenótipos, ao peso e à incidência da síndrome metabólica. Os complexos C 4/5 e C 5 foram separados das outras formas moleculares (C OF ), usando gel de ágar ácido. Resultados: A atividade da BChE (BChEA) e as atividades absolutas de C 4/5 (AC 4/5 ) e de C OF (AC OF ) mostraram altos coeficientes de correlações positivos com peso no grupo de CHE2 C5-, enquanto a atividade relativa do complexo C 5 (RC 5 ) mostrou correlação negativa com o peso. Conclusões: O presente estudo sugere que as correlações positivas das atividades da BChE com diabetes melito e com a resistência à insulina podem depender da variabilidade do loco CHE2. Altos valores nas atividades da BChE estão associados com a resistência à insulina somente nos pacientes diabéticos CHE2 C5-, enquanto nos pacientes diabéticos CHE2 C5+ a presença do complexo C 5 , especialmente em alta proporção relativa, leva a um menor estoque de gordura e à maior proteção contra a síndrome metabólica. Arq Bras Endocrinol Metab. 2010;54(1):60-7 DescritoresLocos BCHE e CHE2; complexos C 4/5 e C 5 ; obesidade, resistência à insulina; síndrome metabólica; colinesterase do soro

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Possible influence of BCHE locus of butyrylcholinesterase on stature and body mass index

Souza

Picheth

Allebrandt

et al. 2004

American J Phys Anthropol

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Butyrylcholinesterase activity has been shown to be positively associated with weight and body mass index (BMI). The present study was carried out to search for an association between variants of the BCHE gene and weight, stature, and BMI on the basis of means and variances compared between nonusual variants and their respective usual controls. Individuals bearing the atypical mutation (N = 52) did not differ from their usual phenotype controls (N = 104) in these parameters. The BCHE*U/BCHE*K individuals (N = 222) presented a significantly higher BMI variance than their BCHE*U/BCHE*U controls (N = 222, F = 1.40, P = 0.012). This higher BMI variance does not seem to be an isolated effect of the K mutation, but appears to be the result of an interaction between the K allele and the usual allele, since no such difference in variance was detected between BCHE*K/BCHE*K individuals (N = 23) and their BCHE*U/BCHE*U (N = 23) controls. These data may suggest a relation between variability in the BCHE locus itself and BMI. Individuals with the BCHE UF phenotype (N = 45) showed a significantly higher mean stature (about 3 cm more; P = 0.02) than their controls with the usual phenotype (N = 135). A role in cell proliferation has been proposed for BCHE, and since growth depends on the number of mitoses, it is not unexpected that variants of this enzyme may influence body stature in different ways. This study reports the first data on the relation of BCHE alleles to anthropometric characters.

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The C<sub>5</sub> Isozyme of Serum Cholinesterase and Adult Weight

Cited by 28 publications

References 28 publications

Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes

Possible influence of BCHE locus of butyrylcholinesterase on stature and body mass index

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