The positivity of Helicobacter pylori Stool Antigen in patients with Hyperemesis gravidarum

Bezircioglu, Incim; Elveren, Hatice Barın; Baloğlu, Ali; Biçer, Merve

doi:10.5152/jtgga.2011.18

Cited by 12 publications

(22 citation statements)

References 18 publications

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“…The results of this study also showed that H. pylori infection was significantly high in the pregnant population with hyperemesis gravidarum accounting 29.6%, and this finding agrees with study conducted in Jeddah, Saudi Arabia, However, in case of Saudi Arabia there was a case control study with hyperemesis gravidarum and without hyperemesis gravidarum [ 19 ]. But this study showed higher result than the study done in Izmir, Turkey, which showed that women who were H. pylori infected with hyperemesis gravidarum were 22.2% [ 20 ]. The possible explanation for this result is that an association of H. pylori and hyperemesis gravidarum could be that an increased accumulation of fluid and a displacement of intracellular and extracellular volume occur as a result of increase in steroid hormones, and this condition results in a change of pH which could lead to the manifestation of a latent H. pylori infection in the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 67%

Burden ofHelicobacter pyloriInfections and Associated Risk Factors among Women of Child Bearing Age in Addis Ababa, Ethiopia

Kitila

Sori

Desalegn

et al. 2018

International Journal of Chronic Diseases

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Background Early detection and treatment of Helicobacter pylori (H. pylori) infection in women of child bearing ages may reduce the risk of maternal health disorder. This study was conducted to determine the burden of H. pylori infections and associated risk factors among women of child bearing ages in Kolfe Keranio Subcity Woreda 9 Health Centers, Addis Ababa, Ethiopia. Methods Facility based cross sectional study design was conducted from April to October 2015. The study recruited 195 pregnant and 137 nonpregnant women with age range of 16-40 years. Sociodemographic data of study participants were collected by structured questionnaire. Venous blood was analyzed to determine hemoglobin, H. pylori stool antigen test kit was used to assess H. pylori infection, and fresh fecal (stool) was used to examine intestinal parasites among study subjects. Data was entered and analyzed using SPSS version 19. Bivariate and multivariate logistic regression model using odds ratio (OR) at 95% confidence interval (CI) were calculated. P-value less than 0.05 was taken as statistically significant. Results The overall burden of H. pylori infection among study participants was 29% (96/332). H. pylori infection was statistically significantly associated with pregnancy status (AOR: 1.825, CI (1.42-2.15), P=0.020), history of hyperemesis gravidarum (AOR=7.028, C.I (2.47-19.99), P=0.018), and low hemoglobin value (AOR=0.177, CI (0.083–0.379), p=0.003). There was no statistically significant association between H. pylori infection and sociodemographic characteristics and some expected risk factors like smoking, Khat chewing, alcohol drinking habit, and presence of intestinal parasites. Conclusion In this study, H. pylori infection was still a public health problem in the study area. H. pylori infected women also had high rate of anemia compared to women who had not H. pylori infected. Hence clinician and other responsible bodies should give a special attention for women who had been infected with H. pylori. Further large case control studies are warranted to understand more the role of H. pylori, HG, and other associated risk factors.

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Section: Discussionmentioning

confidence: 67%

Burden ofHelicobacter pyloriInfections and Associated Risk Factors among Women of Child Bearing Age in Addis Ababa, Ethiopia

Kitila

Sori

Desalegn

et al. 2018

International Journal of Chronic Diseases

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“…In the remaining 48 articles, 16 studies included five studies without control group, two did not provide sufficient data, and 9 reviews or meta-analyses were discarded. Thus, a total of thirty-two studies included twenty-nine case-control studies and three cross-sectional studies published between 1998 and 2014 fulfilled our inclusion criteria and were included in the meta-analysis [ 3 – 6 , 16 – 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…In total, thirteen studies found no association between H. pylori infection and the risk of HG [ 12 , 18 , 20 , 26 , 27 , 32 – 34 , 36 , 38 , 41 – 43 ]. However, nineteen researches suggested H. pylori infection during pregnancy might be a risk factor for pregnant women with HG [ 3 – 6 , 16 , 17 , 19 , 21 , 23 – 25 , 28 – 31 , 35 , 37 , 39 , 40 ]. All included studies contained a total sample size of 4113 patients and contained 1851 HG cases and 2262 controls, with a total H. pylori infection rate of 56.7% (2334/4113).…”

Section: Resultsmentioning

confidence: 99%

“…But a variety of mechanisms may play a role in this disease, such as endocrine factors like human chorionic gonadotropin (HCG), estradiol, and progesterone and immunologic factors, as well as personal factors in which increased body weight has been proposed as possible underlying cause [ 2 ]. Recently, several studies have put emphasis on the correlation between Helicobacter pylori ( H. pylori ) infection and the risk of HG [ 3 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Helicobacter pyloriInfection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis

Zhou

Xiao

et al. 2015

Gastroenterology Research and Practice

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Background. Several studies have shown a possible involvement of Helicobacter pylori (H. pylori) infection in individuals with hyperemesis gravidarum (HG), but the relationship remains controversial. This meta-analysis was performed to validate and strengthen the association between HG and H. pylori infection. Methods. PubMed, Embase, and Web of Science databases up to March 20, 2014, were searched to select studies on the prevalence of H. pylori infection between pregnant women with HG and the normal pregnant control subjects. Results. Of the HG cases, 1289 (69.6%) were H. pylori-positive; however, 1045 (46.2%) were H. pylori-positive in control group. Compared to the non-HG normal pregnant controls, infection rate of H. pylori was significantly higher in pregnant women with HG (OR = 3.34, 95% CI: 2.32–4.81, P < 0.001). Subgroup analysis indicated that H. pylori infection was a risk factor of HG in Asia, Africa, and Oceania, especially in Africa (OR = 12.38, 95% CI: 7.12–21.54, P < 0.001). Conclusions. H. pylori should be considered one of the risk factors of HG, especially in the developing countries. H. pylori eradication could be considered to relieve the symptoms of HG in some intractable cases.

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“…Aksoy et al [13] reported 4 Meckel-Gruber syndrome cases, all of which were accompanied by occipital encephalocele, and occurred between 1990 and 1994. Furthermore, Bezircioglu et al [14] reported an occipital encephalocele case accompanied by situs inversus and polycystic renal disease. Encephaloceles are generally accompanied by facial (20%), skeletal (17%), and renal (13%) anomalies [15] .…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Analysis of Neonatal Encephalocele Predisposing Factors and Outcomes

Yücetaş

Üçler²

2016

Pediatr Neurosurg

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Objective: This study evaluates the predisposing factors and outcomes of surgical management of encephaloceles at our institution. Materials and Methods: A retrospective analysis of 32 occipital encephaloceles managed operatively at the Neurosurgery Department Clinics of the Faculty of Medicine, Adıyaman University, was performed between 2011 and 2015. Results: Among the study population, 19 mothers had been exposed to TORCH infections (toxoplasma, rubella, cytomegalovirus, herpes simplex virus), 18 were in consanguineous marriages, and 3 had regular prenatal screening. Associated congenital anomalies were common. Eight infants required reoperation, and 9 died during follow-up. Conclusions: The study identified key areas for prevention. Knowledge of the intracranial and associated anomalies can guide management.

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The positivity of Helicobacter pylori Stool Antigen in patients with Hyperemesis gravidarum

Abstract: The pregnant women with Hyperemesis gravidarum have a significantly higher prevalence of Helicobacter pylori compared with control subjects.

Cited by 12 publications

References 18 publications

Burden ofHelicobacter pyloriInfections and Associated Risk Factors among Women of Child Bearing Age in Addis Ababa, Ethiopia

Burden ofHelicobacter pyloriInfections and Associated Risk Factors among Women of Child Bearing Age in Addis Ababa, Ethiopia

Helicobacter pyloriInfection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis

A Retrospective Analysis of Neonatal Encephalocele Predisposing Factors and Outcomes

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