The positive adjuvant effect of chitosan on antigen-specific cell-mediated immunity after chickens vaccination with live Newcastle disease vaccine

Rauw, Fabienne; Gardin, Yannick; Palya, Vilmos; Anbari, Sofia; Gonze, M; Lemaire, Sophie; Berg, Thierry van den; Lambrecht, Bénédicte

doi:10.1016/j.vetimm.2009.10.028

Cited by 64 publications

(39 citation statements)

References 56 publications

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“…Chitosan has shown promising results in i.n. split virus vaccines in mice (Bacon et al 2000), split virus and protein vaccines in humans (Read et al 2005;Sui, Chen, Fang, et al 2010;Sui, Chen, Wu, et al 2010) and split virus and DNA vaccines in poultry (Tischer et al 2002;Worrall et al 2009;Huang et al 2010;Rauw et al 2010). However, in our study vaccination with chitosan-adjuvanted inactivated AIV and TMC inactivated AIV particles did not induce AIV-specific serum Ig (de Geus et al 2011).…”

Section: 2contrasting

confidence: 48%

Induction of respiratory immune responses in the chicken; implications for development of mucosal avian influenza virus vaccines

Geus

Rebel

Vervelde

2012

Veterinary Quarterly

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The risk and the size of an outbreak of avian influenza virus (AIV) could be restricted by vaccination of poultry. A vaccine used for rapid intervention during an AIV outbreak should be safe, highly effective after a single administration and suitable for mass application. In the case of AIV, aerosol vaccination using live virus is not desirable because of its zoonotic potential and because of the risk for virus reassortment. The rational design of novel mucosal-inactivated vaccines against AIV requires a comprehensive knowledge of the structure and function of the lung-associated immune system in birds in order to target vaccines appropriately and to design efficient mucosal adjuvants. This review addresses our current understanding of the induction of respiratory immune responses in the chicken. Furthermore, possible mucosal vaccination strategies for AIV are highlighted.

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Section: 2contrasting

confidence: 48%

Induction of respiratory immune responses in the chicken; implications for development of mucosal avian influenza virus vaccines

Geus

Rebel

Vervelde

2012

Veterinary Quarterly

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“…Other uses are, e.g., to give a temporary tissue support in cataract surgery or controlled release of various types of drugs and biomolecules [11,12] and in an interesting combination with Fe3O4 affording a magnetic self-healing hydrogel [13][14][15]. The properties of chitosan, physical and biological, have made it a promising candidate for delivery of pharmaceutically active components and as a delivery vehicle for, e.g., vaccines [16,17], gene fragments [18] and micro-RNA [19]. Drug formulations based on chitosan technology are today under development for many different purposes, e.g., as vaccine carriers [20], drug releasing hydrogels [21], membranes, gauze and more.…”

Section: Open Accessmentioning

confidence: 99%

Characterization and Properties of Hydrogels Made from Neutral Soluble Chitosans

et al. 2015

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Abstract:The current paper focuses on the preparation and some characteristics of viscoelastic hydrogels, ViscoGels™, made from chitosans having a random acylation pattern. Three different chitosan batches with a high fraction of acetylation were selected based on their Mw, and the impact of degree of cross-linking on these chitosan samples has been studied with respect to the properties of the final hydrogels. Rheological long term (12 month) stability and gelling kinetics data are presented together with results from swelling studies at different pH. Finally, an example illustrating these gels potential as drug delivery vehicles is presented and discussed.

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“…Chitosan has shown promising results in i.n. split virus vaccines in mice (Bacon et al, 2000), split virus and protein vaccines in human (Read et al, 2005;Sui et al, 2010a,b) and a split virus vaccine in poultry (Worrall et al, 2009;Rauw et al, 2010). It was previously shown that CT is an effective mucosal adjuvant in chicken (Vervelde et al, 1998), but CT cannot be used in the field because of its toxicity.…”

Section: Introductionmentioning

confidence: 99%

A lack of antibody formation against inactivated influenza virus after aerosol vaccination in presence or absence of adjuvantia

Geus

Haarlem

Poetri

et al. 2011

Veterinary Immunology and Immunopathology

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a b s t r a c tIn the poultry industry, infections with avian influenza virus (AIV) can result in significant economic losses. The risk and the size of an outbreak might be restricted by vaccination of poultry. A vaccine that would be used for rapid intervention during an outbreak should be safe to use, highly effective after a single administration and be suitable for mass application. A vaccine that could be applied by spray or aerosol would be suitable for mass application, but respiratory applied inactivated influenza is poorly immunogenic and needs to be adjuvanted. We chose aluminum OH, chitosan, cholera toxin B subunit (CT-B), and Stimune as adjuvant for an aerosolized vaccine with inactivated H9N2. Each adjuvant was tested in two doses. None of the adjuvanted vaccines induced AIV-specific antibodies after single vaccination, measured 1 and 3 weeks after vaccination by aerosol, in contrast to the intramuscularly applied vaccine. The aerosolized vaccine did enter the chickens' respiratory tract as CT-B-specific serum antibodies were detected after 1 week in chickens vaccinated with the CT-B-adjuvanted vaccine. Chickens showed no adverse effects after the aerosol vaccination based on weight gain and clinical signs. The failure to detect AIV-specific antibodies might be due to the concentration of the inactivated virus.

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The positive adjuvant effect of chitosan on antigen-specific cell-mediated immunity after chickens vaccination with live Newcastle disease vaccine

Cited by 64 publications

References 56 publications

Induction of respiratory immune responses in the chicken; implications for development of mucosal avian influenza virus vaccines

Induction of respiratory immune responses in the chicken; implications for development of mucosal avian influenza virus vaccines

Characterization and Properties of Hydrogels Made from Neutral Soluble Chitosans

A lack of antibody formation against inactivated influenza virus after aerosol vaccination in presence or absence of adjuvantia

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