Characterization and Properties of Hydrogels Made from Neutral Soluble Chitosans

Franzen, Henry M; Draget, Kurt I.; Langebäck, Joakim; Nilsen-Nygaard, Julie

doi:10.3390/polym7030373

Cited by 23 publications

(12 citation statements)

References 27 publications

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“…Similarly, as shown in a study by Rahimi S. and Natan B., it appeared that the K value increased with increasing gel concentration and temperature [42]. The higher viscosity of the F3 formulation than the F1 can be explained by the higher P407 ratio, which has a higher molecular weight and has a different PEO/PPO ratio than the P188 [43].…”

Section: Rheological Studiessupporting

confidence: 56%

Development and Characterization of Mucoadhesive-Thermosensitive Buccal Gel Containing Metronidazole for the Treatment of Oral Mucositis

Ongun¹,

Tunçel²,

Kodan³

et al. 2020

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Objective: This study was aimed to develop and characterize, mucoadhesive-thermosensitive gel formulation containing metronidazole that can quickly gel at the buccal mucosa temperature for treatment of oral mucositis. Material and Method: In this study, the combinations Poloxamer 407 (P407), Poloxamer 188 (P188) and Hydroxypropyl methylcellulose (HPMC) were used in certain concentrations to form a gel in buccal mucosa. Optimum formulations were selected by measuring the gelling time and gelling temperature of the formulations prepared. The hardness, adhesiveness, cohesiveness, resilience, sprayability, mucoadhesion and release properties of selected formulations were evaluated. Result and Discussion: The results showed that F1 and F3 formulations, which quickly turn into gel form at 33 °C, could be the optimum formulations. These two formulations showed controlled release for 8 hours. Texture profile analysis (TPA), mucoadhesion studies and sprayability studies have shown that F1 formulation which the mixture of P407 (15%), P188 (20%) and HPMC (5%) is the optimum formulation for the buccal mucosa. In conclusion, mucoadhesive-thermosensitive gels containing metronidazole may be a good alternative in the treatment of oral mucositis.

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Section: Rheological Studiessupporting

confidence: 56%

Development and Characterization of Mucoadhesive-Thermosensitive Buccal Gel Containing Metronidazole for the Treatment of Oral Mucositis

Ongun¹,

Tunçel²,

Kodan³

et al. 2020

Ankara Universitesi Eczacilik Fakultesi Dergisi

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“…Although a poorer solubility is encountered in homogenously re-acetylated samples with high DA content with respect to commercial ones [ 64 ], the homogeneity of DA distribution is reported to be one of the factors that increases chitosan solubility in aqueous medium as long as the solution pH is kept below 6. This can be reworded by saying that, even when the acetyl groups are randomly distributed, a pH lower than 6 is a prerequisite for chitosan solubilization [ 61 , 65 , 66 ]. On the contrary, the dissolution of chitosan samples with high acetylation content remains troublesome at a molecular level especially at high molar masses [ 64 , 67 , 68 ].…”

Section: A Critical Examination Of the Physico-chemical Propertiesmentioning

confidence: 99%

“The Good, the Bad and the Ugly” of Chitosans

et al. 2016

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The objective of this paper is to emphasize the fact that while consistent interest has been paid to the industrial use of chitosan, minor attention has been devoted to spread the knowledge of a good characterization of its physico-chemical properties. Therefore, the paper attempts to critically comment on the conflicting experimental results, highlighting the facts, the myths and the controversies. The goal is to indicate how to take advantage of chitosan versatility, to learn how to manage its variability and show how to properly tackle some unexpected undesirable features. In the sections of the paper various issues that relate chitosan properties to some basic features and to advanced solutions and applications are presented. The introduction outlines some historical pioneering works, where the chemistry of chitosan was originally explored. Thereafter, particular reference is made to analytical purity, characterization and chain modifications. The macromolecular characterization is mostly related to molecular weight and to degree of acetylation, but also refers to the conformational and rheological properties and solution stability. Then, the antimicrobial activity of chitosan in relation with its solubility is reviewed. A section is dedicated to the formulation of chitosan biomaterials, from gel to nanobeads, exploring their innovative application as active carrier nanoparticles. Finally, the toxicity issue of chitosan as a polymer and as a constructed nanomaterial is briefly commented in the conclusions.

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“…A higher DD makes the chitosan more biocompatible, while a lower DD makes the chitosan more biodegradable [ 1 ]. Moreover, chitosan with a low M w and a high DD shows good solubility in physiological pH environments and exhibits a better antibacterial character than chitosan with a high M w [ 18 , 19 ]. It is worth mentioning that the properties of the prepared membranes using different industrial chitosan powders depend on the M w and the DD .…”

Section: Introductionmentioning

confidence: 99%

Structural, Mechanical, and Transport Properties of Electron Beam-Irradiated Chitosan Membranes at Different Doses

2018

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Abstract:Chitosan powder irradiated by electron beam at different doses, up to 250 kGy, was used to prepare membranes for drug release applications. The irradiation effect on the molecular weight of powder chitosan, the characteristics of the prepared membranes, and their transport of sulfamerazine sodium salt (SULF) were investigated. The effect of the addition of glutaraldehyde (GLA) as a crosslinking agent in the chitosan solution used for the preparation of the membranes was also studied. A decrease in the chitosan molecular weight with the increase in the irradiation dose was observed, while the membranes prepared with the irradiated chitosan at higher dose exhibited lower swelling. However, an opposite behavior was detected when the membranes were prepared with GLA-crosslinked chitosan. A GLA crosslinking agent reduced the crystallinity of the chitosan membranes and the swelling, whereas the water contact angle and SULF transport increased with the increase in the irradiation dose.

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Characterization and Properties of Hydrogels Made from Neutral Soluble Chitosans

Cited by 23 publications

References 27 publications

Development and Characterization of Mucoadhesive-Thermosensitive Buccal Gel Containing Metronidazole for the Treatment of Oral Mucositis

Development and Characterization of Mucoadhesive-Thermosensitive Buccal Gel Containing Metronidazole for the Treatment of Oral Mucositis

“The Good, the Bad and the Ugly” of Chitosans

Structural, Mechanical, and Transport Properties of Electron Beam-Irradiated Chitosan Membranes at Different Doses

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