The plaque inhibitory effect of a CPC mouthrinse in a 3‐day plaque accumulation model – a cross‐over study

Versteeg, P.A.; Rosema, N.A.M.; Hoenderdos, N.L.; Slot, DE; Weijden, G.A. van der

doi:10.1111/j.1601-5037.2009.00421.x

Cited by 21 publications

(26 citation statements)

References 47 publications

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“…Formulations with high bioavailable CPC are associated with greater biological activity and therefore suggest an increased probability for clinical efficiency. 57 Alcohol Alcohol in mouthwashes is used to enhance flavor impact, to solubilize the flavor and some active ingredients, to provide some preservative power, and improve the transport of active ingredients into the dental plaque biofilm. The systematic review by Van Leeuwen and colleagues 30 indicated that the alcohol vehicle solution does not contribute to the efficacy of the mouthwash.…”

Section: Substantivity and Bioavailabilitymentioning

confidence: 99%

Can Chemical Mouthwash Agents Achieve Plaque/Gingivitis Control?

Weijden

Sluijs

Ciancio

et al. 2015

Dental Clinics of North America

104

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Also note that structured abstracts are not allowed per journal style: What is the effect of a mouthwash containing various active chemical ingredients on plaque control and managing gingivitis in adults based on evidence gathered from existing systematic reviews? The summarized evidence suggests that mouthwashes containing chlorhexidine(CHX) and essential oils (EO) had a large effect supported by a strong body of evidence. Also there was strong evidence for a moderate effect of cetylpyridinium chloride(CPC). Evidence suggests that a CHX mouthwash is the first choice, the most reliable alternative is EO. No difference between CHX and EO with respect to gingivitis was observed.

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Section: Substantivity and Bioavailabilitymentioning

confidence: 99%

Can Chemical Mouthwash Agents Achieve Plaque/Gingivitis Control?

Weijden

Sluijs

Ciancio

et al. 2015

Dental Clinics of North America

104

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“…This study design was based in previous works and it was chosen in order to generate the best possible clinical evidence (2,4,8). It measures the plaque regrowth under the influence of test solution from a zero plaque baseline and avoids the confounding influences of tooth brushing (15,16).…”

Section: Discussionmentioning

confidence: 99%

Effect of Ocimum gratissimum in Mouthrinses on De Novo Plaque Formation. A Randomized Clinical Trial

et al. 2016

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The aim of this study was to evaluate the antiplaque effect of Ocimum gratissimum (Og) by in vivo investigation. Fifteen healthy volunteers participated in a crossover, double-blind clinical study, using a 3-day partial-mouth plaque accumulation model. The participants abolished any method of mechanical oral hygiene and they were randomly assigned to initially use just the following mouthrinses: distilled water (DW solution), 0.12% chlorhexidine digluconate (CLX solution) or 10% Og (Og solution). The plaque index (PLI) was recorded in all mandibular teeth at the end of the trial and the Kruskal-Wallis (α=0.05) and Mann-Whitney (α=0.05) tests were used to estimate the difference among groups. The clinical results showed statistically significant difference among the groups (p<0.05), favoring the CLX solution and Og solution, but the first was more effective (p<0.05). The mouthrinses containing 0.12% chlorhexidine digluconate and 10% Og were able to inhibit plaque re-growth, however Og showed more limited results in comparison to CLX.

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“…As examples, Versteeg et al. (22) proved that 0.07% CPC was capable of reducing plaque formation by 47.4% in comparison with placebo, when using the product three times per day. Moran et al.…”

Section: Discussionmentioning

confidence: 99%

Plaque inhibitory effect of a 0.05% cetyl-pyridinium chloride mouth-rinse in a 4-day non-brushing model

Garcia

Rioboo

Serrano

et al. 2010

International Journal of Dental Hygiene

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The plaque inhibitory effect of a CPC mouthrinse in a 3‐day plaque accumulation model – a cross‐over study

Abstract: The CPC mouthrinse proved to be effective in inhibiting 'de novo' plaque formation to an extent similar to that of a 0.1% hexetidine product. Compared with hexetidine, the taste of the CPC was appreciated better and less oral sensations were observed following rinsing.

Cited by 21 publications

References 47 publications

Can Chemical Mouthwash Agents Achieve Plaque/Gingivitis Control?

Can Chemical Mouthwash Agents Achieve Plaque/Gingivitis Control?

Effect of Ocimum gratissimum in Mouthrinses on De Novo Plaque Formation. A Randomized Clinical Trial

Plaque inhibitory effect of a 0.05% cetyl-pyridinium chloride mouth-rinse in a 4-day non-brushing model

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