Effect of Ocimum gratissimum in Mouthrinses on De Novo Plaque Formation. A Randomized Clinical Trial

Abstract

The aim of this study was to evaluate the antiplaque effect of Ocimum gratissimum (Og) by in vivo investigation. Fifteen healthy volunteers participated in a crossover, double-blind clinical study, using a 3-day partial-mouth plaque accumulation model. The participants abolished any method of mechanical oral hygiene and they were randomly assigned to initially use just the following mouthrinses: distilled water (DW solution), 0.12% chlorhexidine digluconate (CLX solution) or 10% Og (Og solution). The plaque index (PLI) was recorded in all mandibular teeth at the end of the trial and the Kruskal-Wallis (α=0.05) and Mann-Whitney (α=0.05) tests were used to estimate the difference among groups. The clinical results showed statistically significant difference among the groups (p<0.05), favoring the CLX solution and Og solution, but the first was more effective (p<0.05). The mouthrinses containing 0.12% chlorhexidine digluconate and 10% Og were able to inhibit plaque re-growth, however Og showed more limited results in comparison to CLX.

Basil

“…Taken together, these results indicate similar efficacy of basil and CLX groups, and no adverse effects were recorded for those using the basil rinse. In a later clinical study by the same research group, 40 a crossover, double-blind trial design was used to evaluate the effectiveness of mouth rinses of this basil and CLX on plaque regrowth in the absence of tooth brushing. Dental plaque remnants were removed from subjects (n = 15), who then rinsed twice daily with control, basil (10% vol/vol essential oil) and CLX (0.12%) formulations for 3 days, while abstaining from mechanical cleaning of teeth.…”