Plaque inhibitory effect of a 0.05% cetyl-pyridinium chloride mouth-rinse in a 4-day non-brushing model

Garcia, VG; Rioboo, M; Serrano, J. A.; O’Connor, Ana; Herrera, David; Sanz, Mariano

doi:10.1111/j.1601-5037.2010.00490.x

Cited by 12 publications

(17 citation statements)

References 26 publications

(37 reference statements)

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“…The sample size was calculated based on the plaque re-growth study previously conducted with the same tested product (12) in which the standard deviation for changes in PlI was 0.72. In order to attain a statistically significant difference (difference 0.75) with a 95% power and taking into account the possible dropouts, it would be necessary to have 30 patients per group.…”

Section: Discussionmentioning

confidence: 99%

“…Calibration between examiners was carried out for both the indexes used (GI and PlI) at baseline and at the end of a previous 4-day experimental study (12). Comparisons were made by means of the kappa test and the 95% confidence interval.…”

Section: Methodsmentioning

confidence: 99%

“…A newly formulated mouth rinse containing CPC has recently been tested in a plaque re‐growth model and has demonstrated efficacy as a plaque inhibitory agent (12). It is therefore the purpose of this investigation to assess whether this efficacy may also be demonstrated in a randomized clinical trial when used as an adjunct to mechanical plaque control in a home study, thus assessing its potential benefits and drawbacks.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and microbiological efficacy of an antimicrobial mouth rinse containing 0.05% cetylpyridinium chloride in patients with gingivitis

Rioboo

Garcia

Serrano

et al. 2011

Int J Dental Hygiene

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical and microbiological efficacy of an antimicrobial mouth rinse containing 0.05% cetylpyridinium chloride in patients with gingivitis

Rioboo

Garcia

Serrano

et al. 2011

Int J Dental Hygiene

Self Cite

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“…Choices of CPC concentration may lead to different patterns of effectiveness [4]. CPC is a quaternary ammonium compound that has the ability to reduce plaque and gingivitis [5]. An additional study about CPC-containing mouth rinses supported the benefit of CPC in decreasing plaque accumulation.…”

Section: Introductionmentioning

confidence: 90%

Efficacy of Mouth Rinse Formulation Based on Cetylpyridinium Chloride 0.1% in the Control of Dental Calculus Buildup

et al. 2017

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Objective: This study aimed at comparing the antiplaque, anticalculus, and antigingivitis potentials of a mouth rinse containing essential oil, alcohol, zinc, and fluoride with a mouth rinse containing cetylpyridinium chloride (CPC) 0.1% over 1-, 2-, and 3-month periods. Methods:This study was a double-blind, parallel randomized clinical trial with a 3-day run-in phase. Respondents were asked to gargle twice daily with 15 ml of mouth rinse for 30 seconds after brushing teeth. Respondents were 80 females with a mean age of 21 years, and a single dental examiner was employed throughout the study to decrease the variance. Prophylaxis was performed for all respondents before the intervention. Three mouth rinses were tested: Group 1 with the mouth rinse containing CPC 0.1%, Group 2 as the negative control, and Group 3 as the positive control with a mouth rinse containing alcohol. Evaluations were conducted by plaque index, gingival index, calculus index, and CariScreen examinations. Results:The clinical trial showed that the mouth rinse with alcohol and the mouth rinse containing CPC 0.1% were effective in inhibiting bacterial buildup (antiplaque) and have anticalculus properties, but with no statistically significant antigingivitis effect. Conclusion:It was found that the mouth rinse containing alcohol has similar effectiveness with CPC 0.1% mouth rinse, but side effects, such as a burning sensation, were reported in the alcohol-containing mouth rinse.

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“…Based on similar studies, a sample size of 15 patients was considered adequate. After the study, a power calculation was performed, showing an 85% power to detect a difference of 0.50 in plaque index among groups, considering a standard deviation of 0.5 (13).…”

Section: Subjectsmentioning

confidence: 99%

Effect of Ocimum gratissimum in Mouthrinses on De Novo Plaque Formation. A Randomized Clinical Trial

et al. 2016

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The aim of this study was to evaluate the antiplaque effect of Ocimum gratissimum (Og) by in vivo investigation. Fifteen healthy volunteers participated in a crossover, double-blind clinical study, using a 3-day partial-mouth plaque accumulation model. The participants abolished any method of mechanical oral hygiene and they were randomly assigned to initially use just the following mouthrinses: distilled water (DW solution), 0.12% chlorhexidine digluconate (CLX solution) or 10% Og (Og solution). The plaque index (PLI) was recorded in all mandibular teeth at the end of the trial and the Kruskal-Wallis (α=0.05) and Mann-Whitney (α=0.05) tests were used to estimate the difference among groups. The clinical results showed statistically significant difference among the groups (p<0.05), favoring the CLX solution and Og solution, but the first was more effective (p<0.05). The mouthrinses containing 0.12% chlorhexidine digluconate and 10% Og were able to inhibit plaque re-growth, however Og showed more limited results in comparison to CLX.

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Plaque inhibitory effect of a 0.05% cetyl-pyridinium chloride mouth-rinse in a 4-day non-brushing model

Abstract: The tested 0.05% CPC mouth-rinse is capable of inhibiting plaque formation.

Cited by 12 publications

References 26 publications

Clinical and microbiological efficacy of an antimicrobial mouth rinse containing 0.05% cetylpyridinium chloride in patients with gingivitis

Clinical and microbiological efficacy of an antimicrobial mouth rinse containing 0.05% cetylpyridinium chloride in patients with gingivitis

Efficacy of Mouth Rinse Formulation Based on Cetylpyridinium Chloride 0.1% in the Control of Dental Calculus Buildup

Effect of Ocimum gratissimum in Mouthrinses on De Novo Plaque Formation. A Randomized Clinical Trial

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