Clinical and microbiological efficacy of an antimicrobial mouth rinse containing 0.05% cetylpyridinium chloride in patients with gingivitis

Rioboo, M; Garcia, VG; Serrano, J. A.; O’Connor, Ana; Herrera, David; Sanz, Mariano

doi:10.1111/j.1601-5037.2011.00523.x

Cited by 16 publications

(11 citation statements)

References 25 publications

(31 reference statements)

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“…25 Four studies showed low risk of bias for the six main domains, except for the seventh field ‘financial conflict of interest’. 12,16,17,21 Three studies showed high risk of bias in four categories. 22–24…”

Section: Resultsmentioning

confidence: 99%

Adverse events associated with home use of mouthrinses: a systematic review

Tartaglia

Tadakamadla

Connelly

et al. 2019

Therapeutic Advances in Drug Safety

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Background: Poor oral hygiene is strongly associated with oral and systemic diseases. Alongside mechanical tooth cleaning, the adjunctive use of mouthrinses has been widely advocated. Although research on the efficacy of various mouthrinse formulations is very active, there are a lack of conclusive data regarding their adverse effects. Methods: We undertook a systematic review in accordance wih PRISMA guidelines of electronic databases of clinical trials of any duration with daily home use of mouthwashes, presenting clinical and subjective side effects (PROSPERO registration: CRD42016054037). Results: After evaluating 614 titles and abstracts, 154 studies were selected for full-text analysis; 85 final papers were included. Based on the active ingredient in the test product, nine categories were created: cetyl pyridinium chloride, essential oils, chlorhexidine, triclosan, natural products, diclofenac, fluorides, delmopinol, and miscellaneous active substances. Most of the studies were of short duration (less than 6 months) with a defective ‘methods’ description; the reporting of adverse events often being overlooked. Both local morphological (oral mucosa and dental-crown staining, mucosal lesions) and functional (taste modifications, abnormal oral sensation) alterations were reported. Tooth staining was the most commonly listed adverse event, but it was quantitatively assessed only in a very small number of papers; most studies relied on patient reports. Staining was time associated; the longer the study, the higher its reported incidence and severity. Conclusions: The reduced report of side effects may partly be due to a lack of an objective measure and lack of general guidelines that demand studies report their adverse events. The most frequently reported adverse effect was teeth staining. As in most studies, the effect was associated with trial duration; clinical trials should be of sufficient duration. New investigations meeting the suggested criteria of a minimal duration of 6 months should be planned.

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Section: Resultsmentioning

confidence: 99%

Adverse events associated with home use of mouthrinses: a systematic review

Tartaglia

Tadakamadla

Connelly

et al. 2019

Therapeutic Advances in Drug Safety

View full text Add to dashboard Cite

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“…However, Rioboo et al . evaluated a 0.05% CPC mouth rinse over a 4‐week study and failed to establish a difference between the test and control products with respect to gingivitis, although they reported a trend for differences in plaque scores. Haps et al .…”

Section: Discussionmentioning

confidence: 99%

Long‐term efficacy of a 0.07% cetylpyridinium chloride mouth rinse in relation to plaque and gingivitis: a 6‐month randomized, vehicle‐controlled clinical trial

Leeuwen

Rosema

Versteeg

et al. 2014

Int J Dental Hygiene

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“…12, 13, 17 Furthermore, individual microbes may react to anti-bacterial agents differently; however, few studies have simultaneously profiled the plethora of bacterial inhabitants of plaque in any cohorts of significant size. 12, 18, 19, 20, 21 Therefore, mechanistic dissection of and eventual rational improvements in the beneficial effects of CPC oral rinses necessitate probing the responses of plaque microbiota to CPC treatment in natural human population.…”

Section: Introductionmentioning

confidence: 99%

Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation

Teng

Huang

et al. 2016

Int J Oral Sci

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Oral rinses containing chemotherapeutic agents, such as cetylpyridinium chloride (CPC), can alleviate plaque-induced gingival infections, but how oral microbiota respond to these treatments in human population remains poorly understood. Via a double-blinded, randomised controlled trial of 91 subjects, the impact of CPC-containing oral rinses on supragingival plaque was investigated in experimental gingivitis, where the subjects, after a 21-day period of dental prophylaxis to achieve healthy gingivae, received either CPC rinses or water for 21 days. Within-subject temporal dynamics of plaque microbiota and symptoms of gingivitis were profiled via 16S ribosomal DNA gene pyrosequencing and assessment with the Mazza gingival index. Cetylpyridinium chloride conferred gingival benefits, as progression of gingival inflammation resulting from a lack of dental hygiene was significantly slower in the mouth rinse group than in the water group due to inhibition of 17 gingivitis-enriched bacterial genera. Tracking of plaque α and β diversity revealed that CPC treatment prevents acquisition of new taxa that would otherwise accumulate but maintains the original biodiversity of healthy plaques. Furthermore, CPC rinses reduced the size, local connectivity and microbiota-wide connectivity of the bacterial correlation network, particularly for nodes representing gingivitis-enriched taxa. The findings of this study provide mechanistic insights into the impact of oral rinses on the progression and maturation of dental plaque in the natural human population.

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Clinical and microbiological efficacy of an antimicrobial mouth rinse containing 0.05% cetylpyridinium chloride in patients with gingivitis

Abstract: the results of this study show limited benefits of the evaluated formulations as adjuncts to unsupervised oral hygiene in reducing plaque accumulation, and no effect on gingivitis.

Cited by 16 publications

References 25 publications

Adverse events associated with home use of mouthrinses: a systematic review

Adverse events associated with home use of mouthrinses: a systematic review

Long‐term efficacy of a 0.07% cetylpyridinium chloride mouth rinse in relation to plaque and gingivitis: a 6‐month randomized, vehicle‐controlled clinical trial

Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation

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