The PI3K signaling-mediated nitric oxide contributes to cardiovascular effects of angiotensin-(1-7) in the nucleus tractus solitarii of rats

Wu, Zhao-Tang; Ren, Changzhen; Yang, Yi; Zhang, Ruwen; Sun, Jia-Cen; Wang, Yang-Kai; Su, Ding‐Feng; Wang, Weizhong

doi:10.1016/j.niox.2015.12.002

Cited by 25 publications

(14 citation statements)

References 51 publications

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“…More importantly, gene transfer of PI3K p110δ shRNA in the RVLM reduced levels of cardiovascular activity, but also inhibits neuroinflammation in Ang II‐induced hypertensive rats and SHR. The subunit p110δ belongs to the catalytic subunit of PI3K, and its blockade effectively prevents activity of PI3K in the RVLM . In this study, there is a limitation that we did not directly observe the effect of PI3K knockdown on the LPS‐induced neuroinflammation.…”

Section: Discussionmentioning

confidence: 91%

The phosphoinositide‐3 kinase signaling is involved in neuroinflammation in hypertensive rats

et al. 2017

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Section: Discussionmentioning

confidence: 91%

The phosphoinositide‐3 kinase signaling is involved in neuroinflammation in hypertensive rats

et al. 2017

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“…Data were acquired by a PowerLab system. The maximum of RSNA was measured when the rat was euthanized with an overdose of pentobarbital sodium (200 mg/kg), as reported previously (Wu et al, 2016). Baseline and constant lightexposed RSNA was analyzed as a percentage of maximal RSNA.…”

Section: Measurements Of Bp Hr and Sympathetic Nerve Activitymentioning

confidence: 99%

Constant Light Exerted Detrimental Cardiovascular Effects Through Sympathetic Hyperactivity in Normal and Heart Failure Rats

Jing¹,

Wu²,

et al. 2020

Front. Neurosci.

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It has been documented that constant light exposure exerts complicated cardiovascular effects. However, a mounting collection of conflicting results did not make it any easier for researchers and physicians to consider the role of light on cardiovascular function. This study was designed to investigate how constant light exposure (24 h light/day) influences the cardiac function in normal and heart-failure (HF) rats. In normal rats, two groups of SD rats were accustomed in 12 h light/12 h dark (LD) or 24 h light (constant light, CL) for 4 weeks. In HF rats which was induced by myocardial infarction (MI) was let recover in LD for 4 weeks. Interestingly, compared with rats in LD environment (ejection fraction, EF%: 93.64 ± 2.02 in LD, 14.62 ± 1.53 in HF-LD), constant light (2 weeks) weakened the cardiac function in normal and HF rats (EF%: 79.42 ± 2.91 in CL, 11.50 ± 1.08 in HF-CL). The levels of renal sympathetic nerve activity and c-fos expression in the rostral ventrolateral medulla (RVLM), a key region controlling sympathetic outflow, were significantly increased in normal and HF rats after

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“…In female rats, central Ang(1–7) protects against aldosterone/NaCl‐induced hypertension, by decreasing heart rate and renal sympathetic nerve activity (Xue et al, ). In Sprague–Dawley rats, Ang(1–7) injected into the nucleus tractus solitarii (NTS) decreases BP, heart rate and renal sympathetic nerve activity through the generation of NO (Wu et al, ).…”

Section: The Progress In Coupling Ang(1–7) Functions With Mas1 Receptorsmentioning

confidence: 99%

Significance of angiotensin 1–7 coupling with MAS1 receptor and other GPCRs to the renin‐angiotensin system: IUPHAR Review 22

Karnik

Singh

Tirupula

et al. 2017

British J Pharmacology

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This paper, written by members of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) subcommittees for the angiotensin receptors, confirms the existing nomenclature for these receptors and reviews our current understanding of their structure, pharmacology and functions, and their likely physiological roles in health and disease. More information on these receptor families can be found in the Concise Guide to PHARMACOLOGY Angiotensins are a group of hormonal peptides and include angiotensin II and angiotensin 1-7 produced by the renin angiotensin system. The biology, pharmacology and biochemistry of the receptors for angiotensins were extensively reviewed recently. In the review, the receptor nomenclature committee was not emphatic on designating MAS1 as the angiotensin 1-7 receptor on the basis of lack of classical G protein signalling and desensitization in response to angiotensin 1-7, as well as a lack of consensus on confirmatory ligand pharmacological analyses. A review of recent publications (2013-2016) on the rapidly progressing research on angiotensin 1-7 revealed that MAS1 and two additional receptors can function as 'angiotensin 1-7 receptors', and this deserves further consideration. In this review we have summarized the information on angiotensin 1-7 receptors and their crosstalk with classical angiotensin II receptors in the context of the functions of the renin angiotensin system. It was concluded that the receptors for angiotensin II and angiotensin 1-7 make up a sophisticated cross-regulated signalling network that modulates the endogenous protective and pathogenic facets of the renin angiotensin system.

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The PI3K signaling-mediated nitric oxide contributes to cardiovascular effects of angiotensin-(1-7) in the nucleus tractus solitarii of rats

Cited by 25 publications

References 51 publications

The phosphoinositide‐3 kinase signaling is involved in neuroinflammation in hypertensive rats

The phosphoinositide‐3 kinase signaling is involved in neuroinflammation in hypertensive rats

Constant Light Exerted Detrimental Cardiovascular Effects Through Sympathetic Hyperactivity in Normal and Heart Failure Rats

Significance of angiotensin 1–7 coupling with MAS1 receptor and other GPCRs to the renin‐angiotensin system: IUPHAR Review 22

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