Constant Light Exerted Detrimental Cardiovascular Effects Through Sympathetic Hyperactivity in Normal and Heart Failure Rats

Jing, Jia-Ni; Wu, Zhao-Tang; Li, Miaoling; Wang, Yang-Kai; Tan, Xing; Wang, Weizhong

doi:10.3389/fnins.2020.00248

Cited by 10 publications

(8 citation statements)

References 61 publications

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“…Besides Adropin, the sympathetic nervous system (SNS) is also disturbed by extended periods of light exposure. Light/dark cycle alterations could modify the norepinephrine (NE) level in tissues innervated by SNS directly by actions on the rostral ventrolateral medulla, superior cervical sympathetic ganglia, and alterations in the hormonal release, resulting in sympathetic hyperactivity [ 26 ]. The hyperactivity of SNS may explain the significant reduction of the RQ toward the fat utilization zone, increased TEE, reduction of food intake, and reduction of weight gain in the CL group.…”

Section: Discussionmentioning

confidence: 99%

Effect of Long-Term Continuous Light Exposure and Western Diet on Adropin Expression, Lipid Metabolism, and Energy Homeostasis in Rats

Abulmeaty

Almajwal

Al‐Numair

et al. 2021

Biology

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Long-term continuous light exposure (CL) and western diet (WD) effects on Adropin expression, RORα, and Rev-erb-α nuclear receptors and energy homeostasis were studied in rats. Thirty-two male Wistar rats (250–290 g) were enrolled for 3 months in the following groups (n = 8/group): (a) Normal control group (NC), (b) CL group, (c) WD group, and (d) CL + WD group. Then, indirect calorimetry and food intake (FI) were measured. Finally, Adropin, hormone-sensitive lipase (HSL), adipocyte triglyceride lipase (ATGL), and free fatty acids (FFA) were measured. Additionally, the histopathology and gene expression of Enho, RORα, and Rev-erb-α genes were done. The CL alone elevated the Adropin plasma level and gene expression, increased RORα expression, and decreased the Rev-erb-α nuclear receptor expression mainly in the liver and kidney. Besides, CL increased the total energy expenditure (TEE) and decreased the respiratory quotient. WD alone or in combination with the CL reversed gene expression of Enho, RORα, and Rev-erb-α. Combined CL and WD increased the TEE, reduced the food intake, increased the ATGL, and reduced the Adropin level in addition to widespread degenerative changes in the liver, spleen, and renal tissues. The deleterious effects of CL and WD on energy homeostasis may include Adropin with the involvement of the RORα and Rev-erb-α nuclear receptors.

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Section: Discussionmentioning

confidence: 99%

Effect of Long-Term Continuous Light Exposure and Western Diet on Adropin Expression, Lipid Metabolism, and Energy Homeostasis in Rats

Abulmeaty

Almajwal

Al‐Numair

et al. 2021

Biology

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“…Constant light has been shown to negatively impact host clock rhythms by causing dampened or arrhythmic clock gene expression and behavioral changes in rodents (Ohta et al, 2006; Mizutani et al, 2017; Jing et al, 2020). If constant light disrupts the monarch’s clock, we should observe effects on clock gene expression.…”

Section: Resultsmentioning

confidence: 99%

Constant Light and Frequent Schedule Changes Do Not Impact Resistance to Parasites in Monarch Butterflies

et al. 2021

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Organisms have evolved internal biological clocks to regulate their activities based on external environmental cues, such as light, temperature, and food. Environmental disruption of these rhythms, such as caused by constant light or frequent light schedule changes, has been shown to impair development, reduce survival, and increase infection susceptibility and disease progression in numerous organisms. However, the precise role of the biological clock in host-parasite interactions is understudied and has focused on unnatural host-parasite combinations in lab-adapted inbred models. Here, we use the natural interaction between monarch butterflies ( Danaus plexippus) and their virulent protozoan parasite, Ophryocystis elektroscirrha, to investigate the effects of constant light and frequent light schedule changes on development, survival, and parasite susceptibility. We show that constant light exposure slows the monarchs’ rate of development but does not increase susceptibility to parasitic infection. Furthermore, frequent schedule changes decrease parasite growth, but have no effect on egg-to-adult survival of infected monarchs. Interestingly, these conditions are usually disruptive to the biological clock, but do not significantly impact the clock of monarch larvae. These unexpected findings show that constant light and frequent schedule changes can uncouple host and parasite performance and highlight how natural relationships are needed to expand our understanding of clocks in host-parasite interactions.

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“…The sham group performed the same operation except ligation of blood vessels. As described in our previous work [ 20 ], the cardiac function of rats in the HF group and the sham group was evaluated by echocardiography 28 days after operation. Briefly, rats were anesthetized with continuous inhalation of 2% isoflurane and transthoracic echocardiography was performed using a high-resolution ultrasound imaging system (Vevo 2100 Linear Imaging System, FUJIFILM Visual Sonics, Toronto, Canada).…”

Section: Methodsmentioning

confidence: 99%

Cellular Phenotypic Transformation in Heart Failure Caused by Coronary Heart Disease and Dilated Cardiomyopathy: Delineating at Single-Cell Level

et al. 2022

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Heart failure (HF) is known as the final manifestation of cardiovascular diseases. Although cellular heterogeneity of the heart is well understood, the phenotypic transformation of cardiac cells in progress of HF remains obscure. This study aimed to analyze phenotypic transformation of cardiac cells in HF through human single-cell RNA transcriptome profile. Here, phenotypic transformation of cardiomyocytes (CMs), endothelial cells (ECs), and fibroblasts was identified by data analysis and animal experiments. Abnormal myosin subunits including the decrease in Myosin Heavy Chain 6, Myosin Light Chain 7 and the increase in Myosin Heavy Chain 7 were found in CMs. Two disease phenotypes of ECs named inflammatory ECs and muscularized ECs were identified. In addition, myofibroblast was increased in HF and highly associated with abnormal extracellular matrix. Our study proposed an integrated map of phenotypic transformation of cardiac cells and highlighted the intercellular communication in HF. This detailed definition of cellular transformation will facilitate cell-based mapping of novel interventional targets for the treatment of HF.

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Constant Light Exerted Detrimental Cardiovascular Effects Through Sympathetic Hyperactivity in Normal and Heart Failure Rats

Cited by 10 publications

References 61 publications

Effect of Long-Term Continuous Light Exposure and Western Diet on Adropin Expression, Lipid Metabolism, and Energy Homeostasis in Rats

Effect of Long-Term Continuous Light Exposure and Western Diet on Adropin Expression, Lipid Metabolism, and Energy Homeostasis in Rats

Constant Light and Frequent Schedule Changes Do Not Impact Resistance to Parasites in Monarch Butterflies

Cellular Phenotypic Transformation in Heart Failure Caused by Coronary Heart Disease and Dilated Cardiomyopathy: Delineating at Single-Cell Level

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