Significance of angiotensin 1–7 coupling with MAS1 receptor and other GPCRs to the renin‐angiotensin system: IUPHAR Review 22

Abstract

This paper, written by members of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) subcommittees for the angiotensin receptors, confirms the existing nomenclature for these receptors and reviews our current understanding of their structure, pharmacology and functions, and their likely physiological roles in health and disease. More information on these receptor families can be found in the Concise Guide to PHARMACOLOGY Angiotensins are a group of hormonal peptides and include angiotensin II and angiotensin 1-7 produced by the renin angiotensin system. The biology, pharmacology and biochemistry of the receptors for angiotensins were extensively reviewed recently. In the review, the receptor nomenclature committee was not emphatic on designating MAS1 as the angiotensin 1-7 receptor on the basis of lack of classical G protein signalling and desensitization in response to angiotensin 1-7, as well as a lack of consensus on confirmatory ligand pharmacological analyses. A review of recent publications (2013-2016) on the rapidly progressing research on angiotensin 1-7 revealed that MAS1 and two additional receptors can function as 'angiotensin 1-7 receptors', and this deserves further consideration. In this review we have summarized the information on angiotensin 1-7 receptors and their crosstalk with classical angiotensin II receptors in the context of the functions of the renin angiotensin system. It was concluded that the receptors for angiotensin II and angiotensin 1-7 make up a sophisticated cross-regulated signalling network that modulates the endogenous protective and pathogenic facets of the renin angiotensin system.

Both aldosterone and spironolactone can modulate the intracellular ACE/ANG II/AT1 and ACE2/ANG (1‐7)/MAS receptor axes in human mesangial cells

“…Indeed, several recent publications have highlighted the crosstalk that occurs between the MAS and ANG II receptors (Karnik et al. ).…”

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

“…A member of Mas-related GPCR family, MrgD, has been shown to react with ANG (1-7) to produce arachidonic acid (461). In addition, the MrgD receptor is responsive to Alamandine.…”

Physiological Roles of Mast Cells: Collegium Internationale Allergologicum Update 2019

“…The renin-angiotensin system (RAS) plays a central role in the homeostatic control of the cardiovascular and renal systems, and in regulating the volume of extracellular fluid [206, 207]. The RAS consists of several enzymatic reactions that generate angiotensin II (ANG II).…”

“…Initially, renin cleaves angiotensinogen to produce ANG I, which is then hydrolyzed by the angiotensin-converting enzyme (ACE) to produce ANG II. This peptide acts on ANG II type 1 receptor (AT 1 R) and AT 2 R. ANG II promotes vasoconstriction, inflammation, salt and water reabsorption, and oxidative stress via the activation of AT 1 R [206, 207]. …”