The Phytochemical screening and the effects of methanolic extract of&lt;i&gt; Phyllanthus amarus&lt;/i&gt; leaf on the Biochemical parameters of Male guinea pigs.

Obianime, AW; Uche, FI

doi:10.4314/jasem.v11i4.55199

Cited by 14 publications

(12 citation statements)

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“…Presence of alkaloids were assessed using Dragendorff's test [20], while carbohydrates and proteins using Molisch and Biuret tests, respectively [21]. In addition, cardiac glycosides were assessed using Concentrated H 2 SO 4 test [22], coumarin using alcoholic sodium hydroxide, flavonoids by Pew's tests [23], saponin using Foam [20], tannins by Ferric chloride test and terpenes using Salkowski's test [22]. Moreover, volatile oils were assessed using oil distillation method.…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Anti-Helicobacter pylori, anti-diabetic and cytotoxicity activity of biosynthesized gold nanoparticles using Moricandia nitens water extract

et al. 2018

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T HIS STUDY aims to synthesize gold nanoparticles (AuNPs) using water extract of Moricandia nitens (Viv.) E. A. Durand & Barratte aerial parts water extract. The presence of various phytochemicals viz. alkaloids, carbohydrates, glycosides, flavonoids, tannins, cumarines, protein and saponins by following standard biochemical methods was investigated. The effect of different parameters such as extract concentration, pH and temperature on the size and morphology of the gold nanoparticles (AuNPs) were studied. The synthesized gold nanoparticles (AuNPs) were characterized by using UV-Vis spectroscopy, FTIR and XRD. The synthesized nanoparticles were found to be spherical in shape with average size in the range of 5 to 20 nm. The green synthesized GNPs were found to be potent inhibitors of α-glucosidase with an IC 50 value of 159.3 μg/ml and showed anti-Helicobacter pylori activity against multidrug resistant H. pylori strains with an MIC 31.25 (µg/ml). Furthermore, biogenic AuNPS possess more significant anticancer activity against HepG2 and HCT-116 withIC 50 = 44.6 ± 0.8 µg/ml and IC 50 = 36 ± 0.7 µg/ml respectively.

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Section: Phytochemical Screeningmentioning

confidence: 99%

Anti-Helicobacter pylori, anti-diabetic and cytotoxicity activity of biosynthesized gold nanoparticles using Moricandia nitens water extract

et al. 2018

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“…VEGF expressions are generally influenced by stimulation of the host, such as estrogen, nitric oxide (NO), various growth factors (bFGF, PDGF, TNF-α, TGF-β, EGF, and IGF1), as well as inflammatory cytokines (IL-6). 15,16 In the early phase, post-extraction inflammation will occur, in which lactate levels increase and oxygen concentration is between 0-10 mmHg. The increased activity of inflammatory cells then leads to a hypoxic atmosphere and elevated lactate levels.…”

Section: Discussionmentioning

confidence: 99%

The increase of VEGF expressions and new blood vessels formation in Wistar rats induced with post-tooth extraction sponge amnion

2018

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Background: Tooth extraction is the process of removing a tooth from the oral cavity potentially triggering a wound healing response in the body. As a result, many methods have been applied to improve the wound healing process, especially in wounds resulting in complications. One such method involves the application of amniotic membrane which has anti-inflammatory, anti-bacterial, anti-fibrosis, anti-scarring properties with low immunogenicity, epithelialization effects, and secretory leukocyte protease inhibitor (SLPI). It also contains collagen, various growth factors, transferrin, fibronectin, nidogen, proteoglycans, hyaluronan, and laminin. Purpose: This study aimed to determine the effects of sponge amnion on the number of VEGF expressions and new blood vessels in post-tooth extraction wounds of Wistar rats. Methods: Sponge amnion was produced by mixing freeze-dried amnion membrane from the Tissue Bank at RSUD Dr. Soetomo with 1% gelatin before freeze drying the mixture. Wistar rats were then divided into two groups. In Group 1, referred to as the control group, the post-extraction wounds of the rats received no treatment. Meanwhile, in Group 2, the treatment group, the subjects’ post-extraction wounds were treated with sponge amnion. The rats of both groups were sacrificed on day 3 to allow observation of the number of VEGF expressions and new blood vessels. A statistical analysis test, a t-test, was subsequently conducted. Results: There was a significant difference in the number of new blood vessels in the control group and that of the treatment group with a p value of 0.018 (p<0.05). There was also a significant difference in VEGF expression between the two groups with a p value of 0.000 (p <0.05). Conclusion: Sponge amnion can generate a number of VEGF expressions and new blood vessels in the post-extraction wounds of Wistar rats.

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“…Preliminary phytochemical analysis was performed as described by [12][13][14] for the following active principles: Tannins, Saponins, Glycosides, Flavonoids, Terpenes, Steroids and Alkaloids.…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Inhibitory Action of Methanol Leaf Extract of Irvingia Gabonensis on the Corrosion of Mild Steel in H2SO4

Ajiwe¹,

Ejike²

2019

AJAC

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The corrosion inhibition efficiency of methanol leaf extracts of Irvingia gabonensis for mild steel in 0.4, 0.5, 0.6 and 2.5M H 2 SO 4 was investigated using weight loss and gasometric techniques in other to determine the phytochemical components of the crude leaf extract, the corrosion inhibition potential of the leaf extract, the thermodynamic parameters that aided the corrosion inhibition, the adsorption isotherm of the corrosion inhibition of the extracts using the Langmuir and Freundlich models and investigate the kinetics of the corrosion inhibition process. Preliminary phytochemical screening revealed the presence of tannins, saponnins, flavonoids, terpenes and alkaloids. From the results, the corrosion rates decreased with increase in inhibitor concentration. The maximum inhibition efficiency of 58.71% was obtained at extract concentration of 0.6g/L in 0.4M H 2 SO 4 at 303K, 41.83% at extract concentration of 0.6g/L at 303K in 0.5M H 2 SO 4 and 57.33% at extract concentration of 0.6g/L in 0.6M H 2 SO 4 at 303K, for the gravimetric technique. In 2.5M H 2 SO 4 , maximum inhibition efficiency for the gasometric technique was 53.53% in 0.6g/L inhibitor concentration at 303K and for the gravimetric technique, the maximum inhibition efficiency was 29.42% in 0.6g/L inhibitor concentration at 303K. The kinetic and thermodynamic studies showed that activation energy (E a) in the presence of inhibitor is greater than in the absence of inhibitor. From the E a and ∆G o ads values obtained, a physical adsorption mechanism was proposed. The Langmuir isotherm was found to show better correlation (R 2) at lower temperature while the Freundlich isotherm had better correlation at higher temperature.

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The Phytochemical screening and the effects of methanolic extract of<i> Phyllanthus amarus</i> leaf on the Biochemical parameters of Male guinea pigs.

Abstract: Pumping test data from twelve boreholes in Azare area were analysed to determine the hydraulic properties of the aquifers, and the availability of water to meet the conjugate demands of the increasing population.

Cited by 14 publications

References 3 publications

Anti-Helicobacter pylori, anti-diabetic and cytotoxicity activity of biosynthesized gold nanoparticles using Moricandia nitens water extract

Anti-Helicobacter pylori, anti-diabetic and cytotoxicity activity of biosynthesized gold nanoparticles using Moricandia nitens water extract

The increase of VEGF expressions and new blood vessels formation in Wistar rats induced with post-tooth extraction sponge amnion

Inhibitory Action of Methanol Leaf Extract of <i>Irvingia Gabonensis</i> on the Corrosion of Mild Steel in H<sub>2</sub>SO<sub>4</sub>

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The Phytochemical screening and the effects of methanolic extract of<i> Phyllanthus amarus</i> leaf on the Biochemical parameters of Male guinea pigs.

Abstract: Pumping test data from twelve boreholes in Azare area were analysed to determine the hydraulic properties of the aquifers, and the availability of water to meet the conjugate demands of the increasing population.

Cited by 14 publications

References 3 publications

Anti-Helicobacter pylori, anti-diabetic and cytotoxicity activity of biosynthesized gold nanoparticles using Moricandia nitens water extract

Anti-Helicobacter pylori, anti-diabetic and cytotoxicity activity of biosynthesized gold nanoparticles using Moricandia nitens water extract

The increase of VEGF expressions and new blood vessels formation in Wistar rats induced with post-tooth extraction sponge amnion

Inhibitory Action of Methanol Leaf Extract of &lt;i&gt;Irvingia Gabonensis&lt;/i&gt; on the Corrosion of Mild Steel in H&lt;sub&gt;2&lt;/sub&gt;SO&lt;sub&gt;4&lt;/sub&gt;

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Inhibitory Action of Methanol Leaf Extract of <i>Irvingia Gabonensis</i> on the Corrosion of Mild Steel in H<sub>2</sub>SO<sub>4</sub>