Abstract:T HIS STUDY aims to synthesize gold nanoparticles (AuNPs) using water extract of Moricandia nitens (Viv.) E. A. Durand & Barratte aerial parts water extract. The presence of various phytochemicals viz. alkaloids, carbohydrates, glycosides, flavonoids, tannins, cumarines, protein and saponins by following standard biochemical methods was investigated. The effect of different parameters such as extract concentration, pH and temperature on the size and morphology of the gold nanoparticles (AuNPs) were studied. Th… Show more
“…2 a, b, c, d) but conversely, the glucose level was still far from the healthy level. The current findings "lined with Daisy & Saipriya [41] reports" concluding that the use of AuNPs reduced glucose concentrations and induced appropriate body weight changes for the treatment of diabetic rats induced with streptozotocin; this may be because the AuNPs might increase fat glucose transporter-4 (GLUT4) [4,42]. As, the GLUT4 glucose transporter is a major mediator of the removal of glucose from circulation and a key regulator of homeostasis of whole-body glucose [43].…”
Section: Effect Of Omega-3 Oils (Flo / Fio) and Aunps On Diabetes Parsupporting
HE aim of the study is to explore the antidiabetic and antioxidant activities of gold nanoparticles (AuNPs) mixed with either flaxseed oil (FLO) or fish oil (FIO). A pyrolysis method was used to prepare AuNPs in oleic acid. The characteristics of the sample were determined by using the transmission electron microscope (TEM) and UV spectroscopy. Male albino rats were divided into two main groups. Group one (n=10 rats) was fed on the basic diet (serves as healthy control). The other group was fed on the high fructose diet (HFD) for four weeks and then was divided into five subgroups. 1 st subgroup was fed on HFD only, 2 nd and 4 th subgroups were fed on HFD mixed with omega-3 oils while 3 rd and 5 th fed on HFD+ omega-3 oils mixed with AuNPs. Results revealed that there was a significant decrease in glucose level, serum insulin, homeostasis model assessment of insulin resistance (HOMA-IR) index and lipid peroxidation in oils nanoparticles treated groups compared to the HFD group and a significant increase in the homeostasis model assessment of β-cell function (HOMA-β) and Glutathione (GSH). It can be concluded that AuNPs mixed omega-3 oils have more anti-diabetic, hepatic protection and antioxidant properties than omega-3 oils alone.
“…2 a, b, c, d) but conversely, the glucose level was still far from the healthy level. The current findings "lined with Daisy & Saipriya [41] reports" concluding that the use of AuNPs reduced glucose concentrations and induced appropriate body weight changes for the treatment of diabetic rats induced with streptozotocin; this may be because the AuNPs might increase fat glucose transporter-4 (GLUT4) [4,42]. As, the GLUT4 glucose transporter is a major mediator of the removal of glucose from circulation and a key regulator of homeostasis of whole-body glucose [43].…”
Section: Effect Of Omega-3 Oils (Flo / Fio) and Aunps On Diabetes Parsupporting
HE aim of the study is to explore the antidiabetic and antioxidant activities of gold nanoparticles (AuNPs) mixed with either flaxseed oil (FLO) or fish oil (FIO). A pyrolysis method was used to prepare AuNPs in oleic acid. The characteristics of the sample were determined by using the transmission electron microscope (TEM) and UV spectroscopy. Male albino rats were divided into two main groups. Group one (n=10 rats) was fed on the basic diet (serves as healthy control). The other group was fed on the high fructose diet (HFD) for four weeks and then was divided into five subgroups. 1 st subgroup was fed on HFD only, 2 nd and 4 th subgroups were fed on HFD mixed with omega-3 oils while 3 rd and 5 th fed on HFD+ omega-3 oils mixed with AuNPs. Results revealed that there was a significant decrease in glucose level, serum insulin, homeostasis model assessment of insulin resistance (HOMA-IR) index and lipid peroxidation in oils nanoparticles treated groups compared to the HFD group and a significant increase in the homeostasis model assessment of β-cell function (HOMA-β) and Glutathione (GSH). It can be concluded that AuNPs mixed omega-3 oils have more anti-diabetic, hepatic protection and antioxidant properties than omega-3 oils alone.
“…Biosynthesized AuNPs have previously been shown to exhibit similar in vitro antidiabetic effect in terms of α-glucosidase activity. 67,116 Figure 11.Comparative analysis of the anti-diabetic effect of the anti-diabetic drug, acarbose, ED-AuNPs, and EDAE.…”
Section: Resultsmentioning
confidence: 99%
“…123,124 Similarly, the antibacterial activity of the biosynthesized AuNPs against H. pylori has been previously reported. 116,125 Figure 12.Comparative analysis of the anti- Helicobacter pylori effect of the antibiotic Clarithromycin, ED-AuNPs, and EDAE.…”
Section: Resultsmentioning
confidence: 99%
“…Biosynthesized AuNPs have previously been shown to exhibit similar in vitro antidiabetic effect in terms of α-glucosidase activity. 67,116 Anti-Helicobacter pylori activity. Helicobacter pylori (H. pylori) is a spiral Gram-negative bacterium known to be colonized in the stomach.…”
Novel metallic nanoparticles (NPs), such as biosynthesized gold nanoparticles (AuNPs), have been extensively studied because of their wide applications. Consequently, the present investigation aimed at the biosynthesis, characterization, and comparative assessment of biological activities of AuNPs. Biosynthesized AuNPs (ED-AuNPs) were synthesized using aqueous extract of Euphorbia dendroides ( E. dendroides) aerial parts (EDAE), which functions as a reducing and stabilizing agent by its nature. Presence of tannins, saponins, flavonoids, alkaloids, glycosides/or carbohydrates, steroids, and terpenes was revealed by the qualitative phytochemical analysis of EDAE. Characterization of the biosynthesized AuNPs was attained by UV-Visible spectrophotometry, transmission electron microscopy (TEM), XRD, and Fourier transform infrared (FTIR). The cytotoxic effects of ED-AuNPs and EDAE were assessed in vitro against HepG2 and HCT-116 cancer cells. The MTT assay revealed a significant cytotoxic effect of ED-AuNPs and EDAE on HepG2 (IC50 = 41.72 ± 1.26 and 55.26 ± 2.25 μg mL−1) as well as HCT-116 (IC50 = 44.96 ± 3.23 and 69.83 ± 0.96 μg mL−1) cells, thus indicating their potential anticancer activity. Furthermore, ED-AuNPs exhibited potent anti-diabetic activity, with an IC50 value of 19.8 ± 1.97 µg mL−1, pointing to their plausible use as therapeutics in the treatment of diabetes, as well as a promising antimicrobial activity against H. pylori.
“…The formed negative anions stabilized by electron resonance hybrid effects enable the reduction of the metal ions with a high degree resulting in the formation of metal ions in a zerovalent state that is related to the generated nanoparticles of smaller size. The process involved an increase in the surface area of the zinc nanoparticles, and accordingly improve the bioactivity of the zinc nanoparticles prepared by W. somnifera leaves extract [68]. The phytochemical analysis of zinc nanoparticles of W. somnifera leaves extract accessible a prominent decrease in the phenolic contents at (48.60 mg gallic acid equivalent / g dry extract) than the W. somnifera leaves extract.…”
Withania somnifera L. is a medicinal herb related to Solanaceae family, known as ashwagandha. The aqueous extract of W. somnifera was utilized for the green synthesis of zinc nanoparticles to investigated their antioxidant and anticancer potentials. The synthesized zinc nanoparticle solution of W. somnifera extract was characterized by phytochemical analysis, Transmission Electron Microscope (TEM), and zeta potential. The results revealed reduced values of the phytochemical constitutes, large surface area, and high stability of the nanoparticles. The antioxidant activity of the extracted W. somnifera and its zinc nanoparticles was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH • ) assay, in which the original extract has the more antioxidant capacity with IC50= 0.701 mg/mL, along with potent results for both samples relative to ascorbic acid. The extracted W. somnifera, its zinc nanoparticles, and zinc sulfate solution were in vitro assessed as anticancer agents on wellknown six human tumor, and a normal cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The results demonstrated that the synthesized zinc nanoparticles of the W. somnifera extract shown the most potent cytotoxicity with IC50= 19.17 µg/mL on HeLa cell line. The synthesized nano-zinc solution of the W. somnifera aqueous extract performed to be proficient as a potent anticancer characteristic than the plant extract with developed biological potency.
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