The physiological function of hyaluronic acid in synovial fluid; viscous, elastic and lubricant properties

Ogston, A. G.; Stanier, J. E.

doi:10.1113/jphysiol.1953.sp004842

Cited by 289 publications

(111 citation statements)

References 14 publications

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“…Amajor component of SF, hyaluronan (HA), has an important role in providing joint lubrication and viscoelasticity to SF (Ogston and Steiner 1953). In human and dog OA and RA, the SF concentration of HA is reduced (Dahl et al 1985, Arican et al 1994.…”

Section: Departments Ofmentioning

confidence: 99%

Elevated levels of synovial fluid PLA₂, strome-lysin (MMP-3) and TIMP in early osteoarthrosis after tibial valgus osteotomy in young beagle dogs

Panula

Lohmander

Rönkkö³

et al. 1998

Acta Orthopaedica Scandinavica

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Section: Departments Ofmentioning

confidence: 99%

Elevated levels of synovial fluid PLA₂, strome-lysin (MMP-3) and TIMP in early osteoarthrosis after tibial valgus osteotomy in young beagle dogs

Panula

Lohmander

Rönkkö³

et al. 1998

Acta Orthopaedica Scandinavica

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“…However, the nature of the surfactant has not been resolved [4,36]. Though earlier models considered hyaluronic acid (HA) as the predominant articular boundary lubricant [28], later work [16,23] showed that HA affected the viscosity of the synovial fluid with insignificant cartilage boundary lubrication. Subsequently, a highly purified glycoprotein fraction isolated from synovial fluid named lubricin, was observed to impart the lubricating properties of synovial fluid [33,[35][36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Phospholipid composition of articular cartilage boundary lubricant

Sarma

Powell

LaBerge

2001

Journal Orthopaedic Research

148

143

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The mechanism of lubrication in normal human joints depends on loading and velocity conditions. Boundary lubrication, a mechanism in which layers of molecules separate opposing surfaces, occurs under severe loading. This study was aimed at characterizing the phospholipid composition of the adsorbed molecular layer on the surface of normal cartilage that performs as a boundary lubricant. The different types of phospholipid adsorbed onto the surface of cartilage were isolated by extraction and identified by chromatography on silica gel paper and mass spectroscopy. The main phospholipid classes identified were quantified by a phosphate assay. Gas chromatography and electrospray ionization mass spectrometry were used to further characterize the fatty acyl chains in each major phospholipid component and to identify the molecular species present. Phosphatidylcholine (41%), phosphatidylethanolamine (27%) and sphingomyelin (32%) were the major components of the lipid layer on the normal cartilage surface. For each lipid type, a mixture of fatty acids was detected, with a higher percentage of unsaturated species compared to saturated species. The most abundant fatty acid observed with all three lipid types was oleic acid (C18:l). Additional work to further quantify the molecular species using electrospray ionization mass spectrometry is recommended.

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“…Finally, it should be emphasized that the gels do not appear to hinder movement or contact between synovial cells, although it has been observed that they do interfere with contact between synovial cells and motile lymphocytes (Fraser and Clarris 1970). This apparent anomaly can be attributed to the fact that lymphocytes in vitro, unlike synovial cells, do not develop any firm attachment to the culture vessel, and therefore cannot develop sufficient thrust to overcome the elastic properties (Ogston and Stanier 1953) of hyaluronic acid gels.…”

Section: Discussionmentioning

confidence: 99%

The Morphology and Motility of Human Synovial Cells and their Pericellular Gels: A Time-Lapse Microcinematographic Study

Fraser¹,

Clarris²,

Kont³

1970

Aust. Jnl. Of Bio. Sci.

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SummaryThe movements of human synovial cells and their associated pericellular gels have been studied by time.lapse microcinematography for periods up to 5 hr.In sparse cultures, changes in cell shape are predominant, with individual cells exhibiting changes in shape common to most types of cell in culture. Cell migration occurs in short random movements in sparse cultures, but in denser cultures migration is mainly, though not entirely, oriented in the long axes of parallel bundles of the cells.The discrepancies between the outlines of the pericellular gels and the cyto· plasmic boundaries can be attributed to the relationships between cell movements and the cohesive properties of the gels. Cells move and make contact freely within the pericellular gels.

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The physiological function of hyaluronic acid in synovial fluid; viscous, elastic and lubricant properties

Cited by 289 publications

References 14 publications

Elevated levels of synovial fluid PLA₂, strome-lysin (MMP-3) and TIMP in early osteoarthrosis after tibial valgus osteotomy in young beagle dogs

Elevated levels of synovial fluid PLA₂, strome-lysin (MMP-3) and TIMP in early osteoarthrosis after tibial valgus osteotomy in young beagle dogs

Phospholipid composition of articular cartilage boundary lubricant

The Morphology and Motility of Human Synovial Cells and their Pericellular Gels: A Time-Lapse Microcinematographic Study

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The physiological function of hyaluronic acid in synovial fluid; viscous, elastic and lubricant properties

Cited by 289 publications

References 14 publications

Elevated levels of synovial fluid PLA2, strome-lysin (MMP-3) and TIMP in early osteoarthrosis after tibial valgus osteotomy in young beagle dogs

Elevated levels of synovial fluid PLA2, strome-lysin (MMP-3) and TIMP in early osteoarthrosis after tibial valgus osteotomy in young beagle dogs

Phospholipid composition of articular cartilage boundary lubricant

The Morphology and Motility of Human Synovial Cells and their Pericellular Gels: A Time-Lapse Microcinematographic Study

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Product

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Elevated levels of synovial fluid PLA₂, strome-lysin (MMP-3) and TIMP in early osteoarthrosis after tibial valgus osteotomy in young beagle dogs

Elevated levels of synovial fluid PLA₂, strome-lysin (MMP-3) and TIMP in early osteoarthrosis after tibial valgus osteotomy in young beagle dogs