The physiologic anticoagulant and anti-inflammatory role of heparins and their utility in the prevention of pregnancy complications

Mastrolia, Salvatore Andrea; Mazor, Moshe; Holcberg, Gershon; Leron, Elad; Beharier, Ofer; Loverro, Giuseppe; Erez, Offer

doi:10.1160/th14-10-0848

Cited by 23 publications

(14 citation statements)

References 106 publications

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“…Heparins reportedly have anti-inflammatory properties mediated by several mechanisms (for a review, see [80,81]), and act to reduce the involvement of several important components, such as histones, L and P-selectin, Mac-1, and PECAM-1, in the inflammatory reaction. For example, heparins limit neutrophil migration into tissues.…”

Section: The Impact Of Anticoagulant Use During Acutephase Thrombosismentioning

confidence: 99%

Inflammation in deep vein thrombosis: a therapeutic target?

et al. 2019

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Deep vein thrombosis is a common disease associated with a variety of complications including post-thrombotic syndrome as a late complication. It is now clear that in addition to classical deep vein thrombosis triggers such as blood flow disturbance, hypercoagulability, and vessel wall changes, inflammation has a key role in the pathophysiology of deep vein thrombosis, and there is a close relationship between inflammation and coagulation. As attested by changes in several plasma biomarkers, inflammation may have a significant role in the development of post-thrombotic syndrome. Here, we review the link between inflammation and deep vein thrombosis and thus the potential value of anti-inflammatory and/or anticoagulant drugs in the treatment of deep vein thrombosis and the prevention of postthrombotic syndrome.

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Section: The Impact Of Anticoagulant Use During Acutephase Thrombosismentioning

confidence: 99%

Inflammation in deep vein thrombosis: a therapeutic target?

et al. 2019

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“…PE causes almost 60,000 maternal deaths annually and affecting 3–5% of pregnancies . Studies have shown that thrombosis along with many alterations in coagulation factors, such as tissues factor pathway inhibitor and tissue factor, are important contributing factors of PE progression …”

Section: Introductionmentioning

confidence: 99%

“…13 Studies have shown that thrombosis along with many alterations in coagulation factors, such as tissues factor pathway inhibitor and tissue factor, are important contributing factors of PE progression. 14 Many reasons such as environmental factors can cause epigenetic changes that include DNA methylation, histone modification, and microRNAs (miRNAs) may be in relation to increased PE disease. The aim of this review study is to evaluate the epigenetic changes in patients with PE as well as the treatment strategies against these changes.…”

Section: Introductionmentioning

confidence: 99%

The role of epigenetic changes in preeclampsia

et al. 2019

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Preeclampsia (PE) is a disorder affecting 2–10% of pregnancies and has a major role for perinatal and maternal mortality and morbidity. PE can be occurred by initiation of new hypertension combined with proteinuria after 20 weeks gestation, as well as various reasons such as inflammatory cytokines, poor trophoblast invasion can be related with PE disease. Environmental factors can cause epigenetic changes including DNA methylation, microRNAs (miRNAs), and histone modification that may be related to different diseases such as PE. Abnormal DNA methylation during placentation is the most important epigenetic factor correlated with PE. Moreover, changes in histone modification like acetylation and also the effect of overregulation or low regulation of miRNAs or long noncoding RNAs on variety signaling pathways can be resulted in PE. The aim of this review is to describe of studies about epigenetic changes in PE and its therapeutic strategies.

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“…Although a great deal of research has been conducted to explore the precise pathogenesis, the complicated molecular mechanism of PE development and progression remains unclear. Accumulating evidence supports the hypothesis that thrombosis, accompanied with many changing coagulation factors such as tissue factor (TF) and tissue factor pathway inhibitor (TFPI), is an important contributing factor of PE development [3][4][5].…”

Section: Introductionmentioning

confidence: 98%