Inflammation in deep vein thrombosis: a therapeutic target?

Borgel, Delphine; Bianchini, Elsa P.; Lasne, Dominique; Pascreau, Tiffany; Saller, François

doi:10.1080/16078454.2019.1687144

Cited by 45 publications

(36 citation statements)

References 101 publications

(120 reference statements)

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“…Increasing evidences have showed that in ammatory response played an important role in the development of DVT. Acute DVT causes a systemic in ammatory response characterized by elevated in ammatory factors and temporal accumulation of in ammatory cells including white blood cells [43,44]. Dawei Liu et al studied 1179 patients of tibial plateau fractures, and found that platelet and neutrophil count were independently associated with elevated D-dimer levels [45].…”

Section: Discussionmentioning

confidence: 99%

Determinants of Elevated D-Dimer Levels and Long-Term Outcome in Elderly Patients With End-Stage Heart Failure

Tian

Yang

Weng

et al. 2021

Preprint

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Background Previous studies have shown that heart failure is associated with hemostatic abnormalities and hypercoagulable state. Plasma D-dimer levels reflect both fibrin formation and degradation, and elevated D-dimer levels have been associated with poor prognosis in patients with heart failure. However, little is known about their roles in elderly patients with end-stage HF. In present study, we aimed to explore the clinical significance and determinants of plasma D-dimer in elderly patients with end-stage heart failure. Methods A total of 177 patients with heart failure at Beijing Geriatric Hospital from November 1, 2015 to December 30, 2018 were enrolled. All hospitalized patients were obtained D-dimer levels within the first 24 h following admission after obtaining informed consent. Primary endpoint was all-cause mortality. Results A total of 60 patients had elevated D-dimer levels. Blood urea nitrogen (β = 1.106, 95% CI: 1.029–1.190, p = 0.006), NYHA functional class (β = 2.179, 95% CI: 1.170–4.056, p = 0.014) and white blood cell counts (β = 1.188, 95% CI: 1.040–1.358, p = 0.011) were independent risk factors for elevated D-dimer in elderly patients with end-stage heart failure. Albumin (β = 0.803, 95% CI: 0.728–0.885, P ༜ 0.001) was negative risk factor for elevated D-dimer in elderly patients with end-stage heart failure. Elevated D-dimer level was independently associated with increased risk of long-term all-cause mortality (P = 0.048). Conclusions For elderly patients with end-stage heart failure, D-dimer levels were associated with white blood cell counts, blood urea nitrogen, albumin and NYHA functional class and elevated D-dimer level was independently associated with poor long-term outcome.

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Section: Discussionmentioning

confidence: 99%

Determinants of Elevated D-Dimer Levels and Long-Term Outcome in Elderly Patients With End-Stage Heart Failure

Tian

Yang

Weng

et al. 2021

Preprint

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“…In conclusion, anticoagulant drugs such as LMWHs have demonstrated the direct potential of their anti-inflammatory capabilities in addition to their anticoagulant properties (37). Moreover, the involvement of inflammation in the pathophysiology of the venous thrombotic process has been clearly established (38). Inflammation is a very interesting tool for evaluating the potential of the new anti-thrombotic drugs (DOACs) targeted to inhibite or reduce inflammatory pathways.…”

Section: Discussionmentioning

confidence: 99%

Direct oral anticoagulant treatment of deep vein thrombosis reduces IL‑6 expression in peripheral mono‑nuclear blood cells

et al. 2020

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Multiple factors play a pathophysiologic role for the venous thromboembolism (VTE) as a multi-factorial disease. Inflammation might play a peculiar role in shifting towards a pro-thrombotic state. Anticoagulant drugs are the first cure line for VTE. The low-molecular-weight heparins (LMWH) show anti-coagulant capability as well as reducing levels of inflammatory factors, including interleukin (IL)-6. The direct oral anticoagulants (DOACs) have shown efficacy in threating VTE, additionally to the anti-activated factor X these drugs seem able to reduce the abnormal release of pro-inflammatory agents. The present study evaluated the capability of DOACs in reducing plasma level of IL-6 in patients suffered from deep vein thrombosis (DVT) of the lower limbs. Our results showed reduced IL-6 expression levels in the peripheral lymphocytes of DVT compared to controls (fold-change, 2.8; P<0.05). We postulate that lowered IL-6 expression in the lymphocytes of DVT patients may mediate the anti-inflammatory action of DOACs. The present study is the first evidence concerning the anti-inflammatory properties of DOACs in specific setting of VTE patients such as DVT.

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“…Increasing evidences have showed that inflammatory response played an important role in development of DVT. In fact, coagulation activation and inflammation reaction are intimately related because multiple cellular factors are involved in both processes, including but not limited to monocyte, neutrophils, and platelets [28][29][30]. In an animal experiment, Bruhl et al [30] demonstrated the monocytes, neutrophils, and platelets cooperated to initiate and propagate venous thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Relationship between the Inflammation/immune Indexes and Deep Venous Thrombosis (DVT) following Tibial Plateau Fractures

Liu¹,

Chen²,

Li³

et al. 2020

Preprint

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Objective To determine the relationship between inflammation/immune-based indexes and preoperative DVT of lower extremities following tibial plateau fracturesMethods Retrospective analysis of a prospectively collected data on patients undergoing surgeries of tibial plateau fractures between October 2014 and December 2018 was performed. Duplex ultrasonography (DUS) was routinely used to screen for preoperative DVT of bilateral lower extremities. Data on biomarkers (neutrophil-, lymphocyte-, monocyte- and platelet counts) at admission were collected, based on which neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte/lymphocyte (MLR) and systemic immune-inflammation index (SII, neutrophil* platelet/ lymphocyte) were calculated. Receiver operating characteristic (ROC) was used to determine the optimal cut-off value for each variable. Multivariate logistic regression analysis was used to evaluate the independent relationship of each biomarker or index with DVT, after adjustment for demographics, co-morbidities and injury-related variables.Results Among 1179 patients included, 16.3% (192/1179) of them had (16.3%) had a preoperative DVT. Among the biomarkers and indexes, only platelet and neutrophil were identified to be independently associated with DVT, and their predictive ability was stable regardless of open fracture with or without included. The other independent variables were elevated D-dimer level (>0.55mg/L), male gender and hypertension in the sensitivity analysis with open fractures excluded.Conclusion These identified factors are conducive to the initial screening for patients at-risk of DVT, individualized risk assessment, risk stratification and accordingly development of targeted prevention programs.

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Inflammation in deep vein thrombosis: a therapeutic target?

Cited by 45 publications

References 101 publications

Determinants of Elevated D-Dimer Levels and Long-Term Outcome in Elderly Patients With End-Stage Heart Failure

Determinants of Elevated D-Dimer Levels and Long-Term Outcome in Elderly Patients With End-Stage Heart Failure

Direct oral anticoagulant treatment of deep vein thrombosis reduces IL‑6 expression in peripheral mono‑nuclear blood cells

Relationship between the Inflammation/immune Indexes and Deep Venous Thrombosis (DVT) following Tibial Plateau Fractures

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