The physical development of children with cystic fibrosis

Kreissl, T; Sw, Bender; Mörchen, R; Hövels, O

doi:10.1007/bf00473404

Cited by 17 publications

(11 citation statements)

References 38 publications

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“…In a report of 1964 [25], length followed the 10th percentile, whereas in later reports [13,17] length was between the 25th and 50th percentile. Our results are similar to previous reports [1,11] and show that length followed the 25th percentile throughout the prepubertal period.…”

Section: Discussionmentioning

confidence: 94%

“…Due to the small number of our patients, we could neither analyse the effect on adult height of various treatment modalities that have been used over the time nor a possible survival effect caused by the long observation period. Theories on the cause of growth impairment in patients with CF have focussed on either malnutrition [4,17,18,23] or pulmonary involvement [13,25]. We have chosen established pulmonary infection as an indicator of pulmonary involvement and evaluated its impact on short-term growth velocity by calculating age independent SD scores during the prepubertal period.…”

Section: Discussionmentioning

confidence: 99%

“…Although the exact cause of inadequate growth is unknown, increased energy needs, decreased energy intake, malabsorption or a combination of these factors probably play an important role. Evaluation of the impact of pulmonary or nutritional factors on growth in patients with CF has shown inconsistent results [4,10,13,15,18,25]. Additionally, intra-uterine [6] and genetic [5] factors as well as retarded pubertal development [16] have been discussed.…”

Section: Introductionmentioning

confidence: 99%

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Perspectives of longitudinal growth in cystic fibrosis from birth to adult age

et al. 1994

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The longitudinal growth in 139 patients with cystic fibrosis (CF) was investigated from birth until the age of 19 years. Already at birth weight and length were reduced (weight: -0.83 +/- 0.13 SDS in girls, -0.44 +/- 0.13 SDS in boys; length: 0.55 +/- 0.13 SDS in girls, -0.39 +/- 0.14 SDS in boys; mean +/- SEM). Both variables showed a further decline until diagnosis was established (weight: -1.57 +/- 0.21 SDS in girls, -1.46 +/- 0.25 SDS in boys; length: -1.15 +/- 0.32 SDS in girls, -1.03 +/- 0.52 SDS in boys; mean +/- SEM). Six to 12 months after diagnosis length improved and reached the 25th percentile in both sexes. Height and weight followed the 25th percentile throughout childhood. Growth velocity was fairly normal during this period. There was a loss in percentiles of both height and weight after the age of 8 years and the pubertal growth spurt was delayed and reduced. However, the 25th percentile was reached again in the adolescent period. At the age of 19 years median height was 161.5 cm in girls and 173 cm in boys, both representing the 25th percentile. Using a sensitive statistical method for analysis of growth data we present CF specific growth curves for height, weight and growth velocity. There was no significant effect of pulmonary colonization with Pseudomonas aeruginosa on growth velocity.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Perspectives of longitudinal growth in cystic fibrosis from birth to adult age

et al. 1994

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“…This concept is supported by the observation that the severity of pulmonary disease correlates better with the growth curves of children with CF than does the degree of malabsorption. 12,13 There should be more emphasis on nutritional management of patients with CF during all phases of the disease process. In all cases, it is essential that treatment of any pulmonary involvement by either antibiotics or physical therapy be accomplished.…”

Section: Nutritional Managementmentioning

confidence: 99%

Nutritional Considerations in Cystic Fibrosis

Hubbard¹

1985

Semin Respir Crit Care Med

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“…However, in creased peripheral circulatory somatostatin concentra tions can in some cases achieve sufficient levels to over ride physiologic hypothalamic control of the pituitary. Hypersomatostatinemia during pharmacotherapy for ac romegaly or in association with somatostatin-secreting pancreatic tumors has been reported to suppress pituitary GH secretion [3][4][5][6], We have recently determined that patients with cystic fibrosis and diabetes (CFDM) have elevated plasma so matostatin concentrations following arginine stimulation [7], This finding provided a functional correlate to pre vious pathological descriptions of increased numbers of somatostatin-containing cells in pancreatic tissue from CFDM patients at autopsy [8,9], Because children with cystic fibrosis (CF) often grow poorly and struggle to maintain body weight [10,11], we were concerned that somatostatin excess might lead to suppression of pituitary GH secretion and decreased anabolic growth in our CF patients. The following studies were performed to deter mine if hypersomatostatinemia in the CFDM group is associated with suppression of pituitary GH secretion.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hypersomatostatinemia on Growth Hormone Secretion in Cystic Fibrosis Patients with Diabetes

Culler

Meacham

1993

Neuroendocrinology

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We have recently shown that hypersomatostatinemia is a feature of cystic fibrosis (CF) when these patients have CF-associated pancreatogenic diabetes mellitus (CFDM). To address the possibility that patients with CFDM might have suppressed pituitary growth hormone (GH) release as a result of increased plasma somatostatin, GH secretion in 8 CFDM patients and 8 normal male controls was studied using a standard arginine infusion stimulus. Concentrations of the GH-dependent peptides, insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) were also measured. We found that mean GH concentrations in the CFDM group were significantly increased (p < 0.05) rather than decreased at the 30-min (12.3 ± 3.6 vs. 3.8 ± 1.9 ng/ml), 45-min (15.4 ± 2.9 vs. 6.1 ± 2.3 ng/ml) and 60-min (13.2 ± 2.3 vs. 6.2 ± 2.2 ng/ml) time points of study. Mean GH area under the curve (633 ± 128 vs. 249 ± 107 ng/ml) was also significantly greater (p < 0.05) in the CFDM group. Despite higher GH levels in the CFDM patients, their IGF-I and IGFBP-3 concentrations were low. We conclude that plasma somatostatin elevations in the CFDM group are not of sufficient magnitude to suppress pituitary GH release. Decreased levels of growth mediating peptides in the relatively malnourished CF subjects suggest a pattern of malnutrition-induced GH resistance which may contribute to poor weight and height gain.

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The physical development of children with cystic fibrosis

Cited by 17 publications

References 38 publications

Perspectives of longitudinal growth in cystic fibrosis from birth to adult age

Perspectives of longitudinal growth in cystic fibrosis from birth to adult age

Nutritional Considerations in Cystic Fibrosis

Effect of Hypersomatostatinemia on Growth Hormone Secretion in Cystic Fibrosis Patients with Diabetes

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