Effect of Hypersomatostatinemia on Growth Hormone Secretion in Cystic Fibrosis Patients with Diabetes

Culler, Floyd L.; Meacham, Lillian R.

doi:10.1159/000126578

Cited by 10 publications

(6 citation statements)

References 19 publications

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“…Our group 12 ' 13 and others 14 have observed normal GH levels in response to secretagogues in children with CF. As presented in the early studies, the impairment in longitudinal growth cannot be explained entirely by poor nutrition, nor can the poor growth in adolescence be explained by lack of sex steroids.…”

Section: Summary Of Poor Growth In Cystic Fibrosismentioning

confidence: 50%

Growth Problems and Growth Hormone Treatment in Children with Cystic Fibrosis

Hardin¹

2002

Journal of Pediatric Endocrinology and Metabolism

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Children with cystic fibrosis (CF) typically demonstrate poor linear growth and, despite aggressive nutritional supplementation, suboptimal weight gain. Growth velocity may be particularly blunted during puberty, a finding that occurs independently of clinical status or sex steroid levels. Several studies indicate that growth hormone (GH) treatment may be associated with significant improvement in both height velocity and weight gain in children with CF. These findings may translate into improvements in clinical status. In our experience, improved growth and weight status have been associated with fewer hospitalizations, fewer antibiotic courses, and improved pulmonary function. A large multicenter trial is currently underway to assess the effect of long-term therapy with GH on the quality of life and pulmonary status.

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Section: Summary Of Poor Growth In Cystic Fibrosismentioning

confidence: 50%

Growth Problems and Growth Hormone Treatment in Children with Cystic Fibrosis

Hardin¹

2002

Journal of Pediatric Endocrinology and Metabolism

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“…The first (23) showed normal GH concentrations in growth-retarded children with CF, the second (27) showed increased GH concentrations in adult diabetic patients and the third (28) showed decreased concentrations of GH in prepubertal children with CF. Thus, a disturbance of the GH/IGF-I axis may be possible, but data are at present limited.…”

Section: Cf-ngt Cf-dm Cf-ngt and Cf-dmmentioning

confidence: 98%

“…Three studies (23,27,28) used standard conditions and methods that are in accordance with the present methods used for GH assessment. The first (23) showed normal GH concentrations in growth-retarded children with CF, the second (27) showed increased GH concentrations in adult diabetic patients and the third (28) showed decreased concentrations of GH in prepubertal children with CF.…”

Section: Cf-ngt Cf-dm Cf-ngt and Cf-dmmentioning

confidence: 99%

Normal spontaneous and stimulated GH levels despite decreased IGF-I concentrations in cystic fibrosis patients

Laursen¹,

Lanng

Rasmussen

et al. 1999

European Journal of Endocrinology

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Objective: The aim of the present study was to investigate whether patients with cystic fibrosis (CF) are GH resistant with increased GH release and decreased concentrations of IGF-I as a result of malabsorption, increased catabolism and impaired glucose tolerance. Design: Twenty CF patients were included, ten with normal glucose tolerance (five male, five female, median age 25.5 years (range 20-31)) and ten with diabetes mellitus (five male, five female, median age 25.3 years (range 17-45). Twenty healthy individuals served as controls (ten male, ten female, median age 28.4 years (range 18-36)). Methods: GH status was evaluated by 12 h spontaneous GH release during the night time, argininestimulated GH release and the basal concentrations of IGF-I and insulin-like growth factor-binding protein-3 (IGFBP-3). Twelve hour spontaneous GH profiles were estimated using a constant blood withdrawal technique with sampling every 30 min and the Pulsar method was used for the analysis of profiles. Results: No significant differences were found in spontaneous and stimulated GH release in CF patients compared with healthy controls, whereas IGF-I and IGFBP-3 were significantly decreased in CF patients compared with healthy controls. The combination of reduced IGF-I and IGFBP-3 with normal GH release points to a relative GH resistance or a disturbance in the pituitary axis in patients with CF. The spontaneous GH release, the stimulated GH release and the basal concentrations of IGF-I and IGFBP-3 were not significantly different in diabetic CF patients compared with CF patients with normal glucose tolerance and the presence of diabetes mellitus was not consistent with increased GH resistance in CF patients. Conclusion: CF patients with normal glucose tolerance and diabetic CF patients had normal GH release and decreased concentrations of IGF-I indicating a relative GH resistance.

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“…Patients with CF were found to have insulin-like growth factor-I (IGF-I) (8,9) and insulin-like growth factor-binding protein-3 (IGFBP-3) (10) de ciency and to have normal (11) or even increased (12) growth hormone (GH) release. This would indicate a relative GH resistance.…”

mentioning

confidence: 99%