The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells

Riahi-Chebbi, Ichrak; Souid, Soumaya; Othman, Houcemeddine; Haoues, Meriam; Karoui, Hakim; Morel, Alain; Srairi-Abid, Najet; Essafi, Makram; Essafi‐Benkhadir, Khadija

doi:10.1038/s41598-018-36808-z

Cited by 105 publications

(96 citation statements)

References 87 publications

(96 reference statements)

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“…Microencapsulation of phenolic compounds have been reported to enhance antitumor activity (Rahaiee, Assadpour, Faridi Esfanjani, Silva, Assadpour, Faridi Esfanjani, Silva, & Jafari, 2020;Riahi-Chebbi et al, 2019). However, what we know is that PCs influenced several…”

Section: Cytotoxic Anti-tumor and And Anticancer Propertiesmentioning

confidence: 99%

Concept, mechanism, and applications of phenolic antioxidants in foods

2020

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In this review, the concept of phenolic antioxidants, mechanisms of action, and applications have been reviewed. Phenolic compounds (PCs) acts as an antioxidant by reacting with a variety of free radicals. The mechanism of antioxidant actions involved either by hydrogen atom transfer, transfer of a single electron, sequential proton loss electron transfer, and chelation of transition metals. In foods, the PCs act as antioxidants which are measured with several in vitro spectroscopic methods. The PCs have been found in milk and a wide range of dairy products with sole purposes of color, taste, storage stability, and quality enhancement. The role of PCs in three types of food additives, that is, antimicrobial, antioxidant, and flavoring agents have been critically reviewed. The literature revealed that PCs present in a variety of foods possess several health benefits such as antibacterial, antihyperlipidemic, anticancer, antioxidants, cardioprotective, neuroprotective, and antidiabetic properties. Practical applications Phenolic compounds are strong antioxidants and are safer than synthetic antioxidants. The wide occurrence in plant foods warranted continuous review applications. This review, therefore, presented an updated comprehensive overview of the concept, mechanism, and applications of phenolic antioxidants in foods.

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Section: Cytotoxic Anti-tumor and And Anticancer Propertiesmentioning

confidence: 99%

Concept, mechanism, and applications of phenolic antioxidants in foods

2020

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“…Induced cell cycle arrest at the G2/M or G0/G1 phase [329,[335][336][337][338][339][340]. Reduced migration and invasion [340][341][342][343][344][345][346]. Inhibited the EMT and reduced resistance to chemotherapeutic agents [343,347].…”

Section: Kaempferolmentioning

confidence: 99%

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Tomko

Whynot

Ellis

et al. 2020

Cancers

149

139

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In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential exploitation in clinical settings. Cannabinoids have been suggested and shown to be effective in the treatment of various conditions. In cancer, the endocannabinoid system is altered in numerous types of tumours and can relate to cancer prognosis and disease outcome. Additionally, cannabinoids display anticancer effects in several models by suppressing the proliferation, migration and/or invasion of cancer cells, as well as tumour angiogenesis. However, the therapeutic use of cannabinoids is currently limited to the treatment of symptoms and pain associated with chemotherapy, while their potential use as cytotoxic drugs in chemotherapy still requires validation in patients. Along with cannabinoids, cannabis contains several other compounds that have also been shown to exert anti-tumorigenic actions. The potential anti-cancer effects of cannabinoids, terpenes and flavonoids, present in cannabis, are explored in this literature review.

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“…Fatty acid: Hexanoic acid, octanoic acid (Raice, Sjoholm, Wang, & Bergenståhl, 2015); Methylcylohex-1-ene (Maroyi, 2018;Mbukwa, Chacha, & Majinda, 2007) Fatty acid ethyl and methyl esters: Ethyl hexanoate, ethyl octanoate, methyl hexanoate, and methyl octanoate (Raice et al, 2015;Riahi-Chebbi et al, 2019) Phytochemicals: Apigenin-7-O-rutinoside, dihydrokaempferol, dihydroquercetin-3′-O -O-glucoside, epiafzelechin, (−)-epicatechin, genistein, luteolin, luteolin-7-O-rutinoside, luteolin-4-O-glucoside, quercetin, and quercetin-3-O-glucoside (Abeer, 2011;Mbukwa et al, 2007); Tomentosolic acid and Vanguerolic acid (Würger, McGaw, & Eloff, 2014) | 9 of 16 OMOTAYO And AREMU for the selected fruit trees is still a problem to be solved in Africa. f. Inadequate knowledge on effective harvesting and storage technique as well as processing facilities: Better understanding of specific harvesting techniques and storage methods for different fruits is needed.…”

Section: Vangueria Infaustamentioning

confidence: 99%

Underutilized African indigenous fruit trees and food–nutrition security: Opportunities, challenges, and prospects

Omotayo

Aremu

2020

Food and Energy Security

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The diverse range of indigenous fruit trees in Africa is a source of untapped potential for food and nutrition security. Here, we review information on 10 indigenous fruit trees that are considered to be underutilized and explore their occurrence, distribution, nutritional components, phytochemicals, and medicinal potentials, as well as their associated challenges and prospects. The indigenous fruit trees, which occur across different ecological zones in Africa, are rich sources of vitamins, minerals, protein, and valuable phytochemicals. They also have recognized medicinal value and used as diverse therapeutic remedies by many ethnic groups in Africa. The key challenges to fruit tree sustainability include indiscriminate and illegal logging, low accessibility, and low acceptability, as well as inadequate research on their cultivation. We proposed a scheme to increase the value chain of underutilized fruit trees, which can contribute to the livelihoods of smallholder farmers and other stakeholders mainly through income generation. In addition to the concerted efforts of multidisciplinary research teams encompassing plant breeders, botanists, molecular biologists, food scientists, and horticulturists, there is an urgent need for governments and other international stakeholders to provide incentives and encourage the domestication, commercialization, and agro‐processing of underutilized fruit trees for future economic prosperity of Africa.

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The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells

Cited by 105 publications

References 87 publications

Concept, mechanism, and applications of phenolic antioxidants in foods

Concept, mechanism, and applications of phenolic antioxidants in foods

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Underutilized African indigenous fruit trees and food–nutrition security: Opportunities, challenges, and prospects

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