Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Tomko, Andrea M.; Whynot, Erin G.; Ellis, Lee; Dupré, Denis J.

doi:10.3390/cancers12071985

Cited by 151 publications

(172 citation statements)

References 433 publications

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“…Among natural compounds, several sesquiterpenes, a subclass of terpenoids known to mediate biotic interactions among plants and/or other organisms [ 42 ], have been highlighted to possess interesting pharmacological activities, which include the ability to suppress cancer cell proliferation and reverse multidrug resistance [ 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

“…Among them, β-caryophyllene and β-caryophyllene oxide are the most studied, and an interest in their potential anticancer properties has been hypothesized [ 45 ]. However, emerging evidence has outlined a complex polypharmacological profile of caryophyllane sesquiterpene, characterized by blocking, suppressing, chemosensitizing, and cytoprotective properties, which suggests their possible usefulness as chemopreventive agents to be exploited for both preventive and adjuvant purposes.…”

Section: Introductionmentioning

confidence: 99%

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Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence

Sotto

Mancinelli

Gullì

et al. 2020

Cancers

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Chemoprevention is referred to as a strategy to inhibit, suppress, or reverse tumor development and progression in healthy people along with high-risk subjects and oncologic patients through using pharmacological or natural substances. Numerous phytochemicals have been widely described in the literature to possess chemopreventive properties, although their clinical usefulness remains to be defined. Among them, caryophyllane sesquiterpenes are natural compounds widely occurring in nature kingdoms, especially in plants, fungi, and marine environments. Several structures, characterized by a common caryophyllane skeleton with further rearrangements, have been identified, but those isolated from plant essential oils, including β-caryophyllene, β-caryophyllene oxide, α-humulene, and isocaryophyllene, have attracted the greatest pharmacological attention. Emerging evidence has outlined a complex polypharmacological profile of caryophyllane sesquiterpenes characterized by blocking, suppressing, chemosensitizing, and cytoprotective properties, which suggests a possible usefulness of these natural substances in cancer chemoprevention for both preventive and adjuvant purposes. In the present review, the scientific knowledge about the chemopreventive properties of caryophyllane sesquiterpenes and the mechanisms involved have been collected and discussed; moreover, possible structure–activity relationships have been highlighted. Although further high-quality studies are required, the promising preclinical findings and the safe pharmacological profile encourage further studies to define a clinical usefulness of caryophyllane sesquiterpenes in primary, secondary, or tertiary chemoprevention.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence

Sotto

Mancinelli

Gullì

et al. 2020

Cancers

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“…However, the evidence which supports the efficacy of Cannabis as analgesia is being accumulated. Especially, cases of prescribing Cannabis (CBD, THC, CBD + THC) for diseases caused by cancer [ 36 - 40 ] and other refractory diseases [ 41 - 45 ] are increasing. In addition, research and clinical cases indicating the effectiveness of Cannabis (CBD, THC, CBD + THC) for degenerative brain lesions (e.g., dementia, Alzheimer’s disease, Parkinson’s disease) and neurological diseases are increasing [ 46 - 49 ].…”

Section: Discussionmentioning

confidence: 99%

A Literature Analysis on Medicinal Use and Research of Cannabis in the Meiji Era of Japan

Ahn

Kang²,

Lee³

et al. 2020

J Pharmacopuncture

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Cannabis is a historical plant which has been used as a medicine in East Asia. These days, there are active debates about using cannabis in clinical field. Collecting and comparing cannabis research articles which had been published in the Opening of Japan to spot the interactions between the traditional medicine of Japan, Rangaku which was established in Edo Period and the European medicine which is transferred after Perry Expedition is academically meaningful. This study searched publications, which were listed on Open-Access databases by Dec. 11 th , 2019. We collected research articles which had been published from January 3 rd , 1867 to July 30 th , 1912 also known as Meiji era and uploaded on Open-Access databases. Our searching databases were J-stage, CiNii (Scholarly and Academic Information Navigator), Tokyo Metropolitan Library, The National Diet Library, IRDB (Institutional Repositories DataBase) and KAKEN (Grant-in-Aid for Scientific Research Database). Searching keywords were cannabis, hemp and all their Japanese synonyms and available combinations. We selected final 15 studies which met every selection criteria in the 346,393 collected studies. Cannabis was prescribed in Meiji era of Japan to alleviate pain and cure the digestive, respiratory, urinary, and nervous system diseases such as indigestion, asthma, tuberculosis, gonorrhea and its complications, insomnia, and nervous prostration. Cannabis was medically used in Meiji era of Japan and the reporting and sharing of its clinical effect was published on the medical journals like present days. There were already Cannabis regulations in that era, but its medicinal use was more liberated than nowadays. It may be a chance to reconsider the current legal system, which strictly controls the use of Cannabis.

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“…β-farnesene is one of the essential sesquiterpenes used in the treatment of different types of cancer including breast, lung, and prostate [ 40 , 41 , 42 ]. This organic compound is suppressing tumor proliferation through tumor apoptotic pathways.…”

Section: Mechanisms Of Plant-derived Agents Induced Cell Deathmentioning

confidence: 99%

“…This compound uses various pathways to induce tumor cell death. In vitro effects of α-Humulene include increased production of ROS and inhibition of Akt activation [ 42 , 48 ].…”

Section: Mechanisms Of Plant-derived Agents Induced Cell Deathmentioning

confidence: 99%

Potential Treatment of Breast and Lung Cancer Using Dicoma anomala, an African Medicinal Plant

2020

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Globally, cancer has been identified as one of the leading causes of death in public health. Its etiology is based on consistent exposure to carcinogenic. Plant-derived anticancer compounds are known to be less toxic to the normal cells and are classified into acetylenic compounds, phenolics, terpenes, and phytosterols. Dicoma anomala is a perennial herb belonging to the family Asteraceae and is widely distributed in Sub-Saharan Africa and used in the treatment of cancer, malaria, fever, diabetes, ulcers, cold, and cough. This review aimed at highlighting the benefits of D. anomala in various therapeutic applications with special reference to the treatment of cancers and the mechanisms through which the plant-derived agents induce cell death.

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Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Cited by 151 publications

References 433 publications

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence

A Literature Analysis on Medicinal Use and Research of Cannabis in the Meiji Era of Japan

Potential Treatment of Breast and Lung Cancer Using Dicoma anomala, an African Medicinal Plant

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