The pharmacology of isometamidium

Kinabo, L. D. B.; Bogan, J. A.

doi:10.1111/j.1365-2885.1988.tb00148.x

Cited by 38 publications

(25 citation statements)

References 67 publications

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“…TCB is not licensed for use in lactating species. Kinabo and Bogan [117] found that TCB residues could be detected in goat milk for up to 6 days post-treatment. Counotte et al [118] found that TCB residues could be detected in cow milk up to 10 days posttreatment.…”

Section: Discussionmentioning

confidence: 98%

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Review of methodology for the determination of benzimidazole residues in biological matrices

Danaher

Ruyck

Crooks

et al. 2007

Journal of Chromatography B

181

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Section: Discussionmentioning

confidence: 98%

“…Kinabo and Bogan [117] showed that TCB-SO and TCB-SO 2 could be detected up to 3 and 6 days in the milk of goats treated with an oral dose of TCB (12 mg/kg bw). TCB parent drug was not detectable at any timepoint.…”

Section: Triclabendazolementioning

confidence: 98%

Review of methodology for the determination of benzimidazole residues in biological matrices

Danaher

Ruyck

Crooks

et al. 2007

Journal of Chromatography B

181

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“…Sfa NI restriction sites are shaded in dark. TbAT1S and TbAT1R refer to the nucleotide sequences in the wild-type and mutant-type TbATl, respectively (GenBank accession numbers AF152369 and AF152370, respectively) exclusively as veterinary trypanocide, both prophylactically and therapeutically (Kinabo and Bogan 1988). The resistance to isometamidium is a serious problem in many parts of sub-Saharan Africa.…”

Section: Discussionmentioning

confidence: 99%

Rapid identification of isometamidium-resistant stocks of Trypanosoma b. brucei by PCR–RFLP

Afework

Mäser²,

Etschmann

et al. 2006

Parasitol Res

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Analyses were made on the adenosine transporter-1 gene in Trypanosoma brucei (TbAT1), encoding a P2-like nucleoside transporter, from T. brucei brucei field stocks to investigate a possible link between the presence of mutations in this gene and isometamidium resistance. We have analysed the gene from 11 isometamidium-sensitive field stocks isolated from cattle in Uganda, two sensitive reference clones and two resistant reference clones. A sequence alignment showed that the isometamidium-sensitive T. b. brucei contained the wild-type sequence patterns. In contrast, the isometamidium-resistant T. b. brucei stocks showed the mutant-type sequence patterns with six point mutations that had previously been reported in a laboratory-derived arsenical-resistant T. brucei strain. To analyse the restriction fragment length polymorphism pattern of a fragment of TbAT1 (nucleotides 430-1108), the 677-bp polymerase chain reaction products from eight of the isometamidium-sensitive and two of the isometamidium-resistant T. b. brucei were subjected to digestion with Sfa NI. The results revealed two different banding patterns: the digest resulted in fragment sizes of 566 and 111 bp in the case of TbAT1 from isometamidium-sensitive stocks, whereas it produced fragment sizes of 435 and 242 bp in the case of TbAT1 from isometamidium-resistant stocks. Thus, the isometamidium-sensitive and isometamidium-resistant T. b. brucei could be successfully distinguished by digestion with the restriction endonuclease Sfa NI.

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“…While the pharmacokinetics of parvaquone and buparvaquone have been compared (Kinabo and Bogan, 1988), no information is available on the disposition kinetics of halofuginone in cattle due to lack of suitable analytical methods.…”

Section: Ntrod U Cti 0 Nmentioning

confidence: 99%

Determination of halofuginone in bovine plasma by competing‐ion high performance liquid chromatography after solid phase extraction

Kinabo

McKellar

Murray

1989

Biomedical Chromatography

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A high performance liquid chromatography (HPLC) method for the determination of the anticoccidial and antitheilerial drug halofuginone in bovine plasma was developed. Samples were diluted with acetic acid (10%, v/v) and cleaned up on a Bond Elut C8 column. The analyte was eluted from the extraction column and chromatographed by reversed-phase HPLC using decylamine as a competing-ion reagent. Detection was by UV at 243 nm. Recovery from plasma was 75%, and within-day and between-day coefficients of variation were 5.23 and 6.35% respectively. The specificity and sensitivity of this method (limit of detection in plasma, 1 ng/mL) were sufficiently high to enable us to characterize the time course of the drug in plasma after oral administration of therapeutic doses to cattle.

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The pharmacology of isometamidium

Cited by 38 publications

References 67 publications

Review of methodology for the determination of benzimidazole residues in biological matrices

Review of methodology for the determination of benzimidazole residues in biological matrices

Rapid identification of isometamidium-resistant stocks of Trypanosoma b. brucei by PCR–RFLP

Determination of halofuginone in bovine plasma by competing‐ion high performance liquid chromatography after solid phase extraction

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