The Pharmacological Effects and Mechanism of<i>Tripterygium wilfordii</i>Hook F in Central Nervous System Autoimmunity

Wang, Qing; Jian, Meng; Dong, A.; Yu, Jie‐Zhong; Zhang, Guang‐Xian; Ma, Cun‐Gen

doi:10.1089/acm.2016.0004

Cited by 21 publications

(10 citation statements)

References 43 publications

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“…These beneficial effects of TwHF therapy may be related to its ability to improve podocyte slit diaphragm or mesangial injury (Wan et al, 2011;Wan, Sun, & Zhen, 2005 (Fan, Parhira, Zhu, Jiang, & Bai, 2016;Wang et al, 2016a), and its effective dose and toxic dose are very close (Li, Jiang, & Zhang, 2014b). So proper dose contributes to the reduction of its toxicity.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Tripterygium wilfordii Hook F for CKD in Mainland China: A systematic review and meta‐analysis

Wang

Zhao

Cui³

et al. 2017

Phytotherapy Research

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Tripterygium wilfordii Hook F (TwHF) is a promising Chinese traditional medicine used to significantly reduce proteinuria and improve renal function. However, its efficacy and safety in treatment of chronic kidney disease need to be further explored in order to promote its application in clinics. This review compared the efficacy and safety of TwHF with the placebo, conventional Western medicine and other immunosuppressive medicine in a range of kidney disorders. One hundred three randomized controlled trials were included. TwHF therapy decreased 24-hr proteinuria by 0.59 g/day (95% confidence interval [CI; -0.68, -0.50]), serum creatinine level by 1.93 μmol/L (95% CI [-3.69, -0.17]), and blood urea nitrogen level by 0.24 mmol/L (95% CI [-0.41, -0.07]); increased the total effective rate by 27% (95% CI [1.24, 1.30]); and decreased the incidence of adverse reactions by 19% (95% CI [0.68, 0.96]) overall. Meta regression results showed that the duration of therapy and mean age of participants were the major sources of high heterogeneity. Sensitivity analysis demonstrated that our statistic results were relatively stable and credible. The present findings suggested that TwHF possibly has nephroprotective effects by decreasing proteinuria, serum creatinine level, and blood urea nitrogen level and no more adverse reactions compared with control group in most kidney disorders. However, these findings still need to be further confirmed by high-quality trials.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Tripterygium wilfordii Hook F for CKD in Mainland China: A systematic review and meta‐analysis

Wang

Zhao

Cui³

et al. 2017

Phytotherapy Research

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“…Triptolide belongs to the Celastraceae family and is used extensively as an antirheumatoid, anti-eczema, immunosuppressive, nephrotic syndrome and malignant tumour agent in traditional Chinese medicine. The pharmacological effects of TPL are attributed to its anti-inflammatory, analgesic, anti-tumor and immune-regulating properties [ 1 ]. However, the oral intake of TPL exists in a high-toxicity region, and the digestive system and urogenital system have adverse reaction rates of 35.8 and 22.8%, respectively [ 2 ], severely limiting its clinical application.…”

Section: Introductionmentioning

confidence: 99%

Development of triptolide-nanoemulsion gels for percutaneous administration: physicochemical, transport, pharmacokinetic and pharmacodynamic characteristics

Yang

et al. 2017

J Nanobiotechnol

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BackgroundThis work aimed to provide useful information on the use of nanoemulsions for the percutaneous administration of triptolide. Lipid nanosystems have great potential for transdermal drug delivery. Nanoemulsions and nanoemulsion gels were prepared to enhance percutaneous permeation. Microstructure and in vitro/in vivo percutaneous delivery characteristics of triptolide (TPL)-nanoemulsions and TPL-nanoemulsion gels were compared. The integrity of the nanoemulsions and nanoemulsion gels during transdermal delivery and its effects on the surface of skin were also investigated. The penetration mechanisms of nanoemulsions and nanoemulsion gels were investigated by differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The transport characteristics of fluorescence-labelled nanoemulsions were probed using laser scanning confocal microscopy. A chronic dermatitis/eczema model in mice ears and the pharmacodynamic of the TPL-nanoemulsion gels were also investigated.ResultsCompared to TPL gels, significantly greater cumulative amounts of TPL-nanoemulsion gels and TPL-nanoemulsions penetrated rat skin in vitro. The in vivo microdialysis showed the concentration–time curve AUC0–t for TPL-NPs is bigger than the TPL-gels. At the same time, TPL-NPs had a larger effect on the surface of skin. By hydrating keratin and changing the structure of both the stratum corneum lipids and keratin, nanoemulsions and nanoemulsion gels influence skin to promote percutaneous drug penetration. Both hairfollicles and the stratum corneum are also important in this transdermal drug delivery system. Moderate and high dosages of the TPL-nanoemulsion gels can significantly improve the symptoms of dermatitis/eczema inflammation and edema erythematic in mice ears and can reduce the expression of IFN-γ and IL-4. Moreover, the TPL-nanoemulsion gels cause less gastrointestinal damage than that of the Tripterygium wilfordii oral tablet does.ConclusionsNanoemulsions could be suitable for transdermal stably releasing drugs and maintaining the effective drug concentration. The TPL-nanoemulsion gels provided higher percutaneous amounts than other carriers did. These findings suggest that nanoemulsion gels could be promising percutaneous carriers for TPL. The TPL-nanoemulsion gels have a significant treatment effect on dermatitis/eczema in the mice model and is expected to provide a new, low-toxicity and long-term preparation for the clinical treatment of dermatitis/eczema in transdermal drug delivery systems.Electronic supplementary materialThe online version of this article (10.1186/s12951-017-0323-0) contains supplementary material, which is available to authorized users.

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“…F. is a traditional Chinese medicinal herb, commonly known as "Thunder God Vine" or "Lei Gong Teng" (Figure 1 ). It is mainly used to treat autoimmune and inflammatory diseases, such as rheumatoid arthritis and systemic lupus erythematosus 1 , and its main active compounds are terpenoids including triptolide and celastrol. Triptolide (Figure 2 ) is currently considered to be one of the active compounds most likely to translate from traditional to modern medicine 2 .…”

Section: Introductionmentioning

confidence: 99%

Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives

Gao¹,

Zhang²,

Liu³

et al. 2021

Theranostics

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Triptolide, an abietane-type diterpenoid isolated from Tripterygium wilfordii Hook. F., has significant pharmacological activity. Research results show that triptolide has obvious inhibitory effects on many solid tumors. Therefore, triptolide has become one of the lead compounds candidates for being the next "blockbuster" drug, and multiple triptolide derivatives have entered clinical research. An increasing number of researchers have developed triptolide synthesis methods to meet the clinical need. To provide new ideas for researchers in different disciplines and connect different disciplines with researchers aiming to solve scientific problems more efficiently, this article reviews the research progress made with analyzes of triptolide pharmacological activity, biosynthetic pathways, and chemical synthesis pathways and reported in toxicological and clinical studies of derivatives over the past 20 years, which have laid the foundation for subsequent researchers to study triptolide in many ways.

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The Pharmacological Effects and Mechanism ofTripterygium wilfordiiHook F in Central Nervous System Autoimmunity

Abstract: This review systematically summarizes the effects, safety consideration, and molecular mechanisms of action of TwHF extracts with regard to their inhibition of microglia activation, T cell functions, and transcriptional activation of nuclear factor (NF)-κB signaling.

Cited by 21 publications

References 43 publications

Efficacy and safety of Tripterygium wilfordii Hook F for CKD in Mainland China: A systematic review and meta‐analysis

Efficacy and safety of Tripterygium wilfordii Hook F for CKD in Mainland China: A systematic review and meta‐analysis

Development of triptolide-nanoemulsion gels for percutaneous administration: physicochemical, transport, pharmacokinetic and pharmacodynamic characteristics

Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives

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