The pharmacokinetics of fenbendazole and oxfendazole in cattle

Ngomuo, A. J.; Marriner, S. E.; Bogan, J. A.

doi:10.1007/bf02214711

Cited by 53 publications

(25 citation statements)

References 9 publications

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“…The avid binding of febantel, fenbendazole and fenbendazole sulfone to camel serum (over 85%) is inversely related to their solubility. Oxfendazole, which is the most soluble of this series of benzimidazole anthelmintics (Ngomuo. 1983: Ngomuo et al.…”

Section: Discussionmentioning

confidence: 99%

The bioavailability of febantel in dehydrated camels

Ben‐Zvi

Gussarsky

Creveld

et al. 1996

Vet Pharm & Therapeutics

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In the present study the bioavailability of febantel paste and febantel suspension was investigated in the fully hydrated and the dehydrated camel. The serum concentrations of febantel and its metabolites, fenbendazole, oxfendazole and fenbendazole sulfone were determined by high performance liquid chromatography following extraction with ether. The exposure to febantel and its metabolites in fully hydrated camels was significantly higher in camels dosed with febantel paste compared to febantel suspension, as measured by AUC and Cmax. The AUC and Cmax of fenbendazole and oxfendazole were significantly lower in dehydrated camels as compared to control camels dosed with febantel paste. The systemic availability of febantel suspension in control and dehydrated camels was very low and differences between dehydration and control phases were insignificant. The low systemic availability of febantel in camels dosed with febantel suspension may cause nematodes to become resistant to this anthelmintic. It is, thus, suggested to increase the dose of febantel paste in dehydrated camels in order to increase the exposure to febantel and its metabolites. The binding of febantel, fenbendazole, oxfendazole and fenbendazole sulfone to camels' serum proteins was over 85%. Oxfendazole was only about 70% bound. Dehydration of 10 days did not affect the binding of these benzimidazole derivatives to serum proteins.

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Section: Discussionmentioning

confidence: 99%

The bioavailability of febantel in dehydrated camels

Ben‐Zvi

Gussarsky

Creveld

et al. 1996

Vet Pharm & Therapeutics

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“…Bogan and Marriner [139] adjusted the pH of plasma to pH 7.4 before extracting FBZ, OFZ and ABZ residues with diethyl ether. Bogan's procedure has been applied for isolation of benzimidazole residues from plasma and blood [140][141][142]. Other groups have developed alternative procedures, while substituting solvents such as chloroform [143,144] and ethyl acetate [145][146][147] for diethyl ether.…”

Section: Plasma Serum or Other Biological Fluidsmentioning

confidence: 99%

Review of methodology for the determination of benzimidazole residues in biological matrices

Danaher

Ruyck

Crooks

et al. 2007

Journal of Chromatography B

184

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“…by oxidative metabolism in other species. Additionally, the pharmacokinetics of FBZ have been reported in several species including cattle (Duwel et al, 1975;Duwel, 19n;Pritchard et al, 1983;Ngomuo et al, 1984), sheep (Duwel et al, 1975;Marriner and Bogan, 1981), horses (Marriner and Bogan, 1985), pigs (Duwel, 1977) and rabbits (Duwel et al, 1975), allowing comparisons to be made between species.…”

Section: Resultsmentioning

confidence: 95%

Pharmacokinetics and metabolism of fenbendazole in channel catfish

Kitzman

Holley²,

Huber³

et al. 1990

Veterinary Research Communications

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Fenbendazole (FBZ) was administered intravenously (1 mg/kg) and orally (5 mg/kg) to catheterized, confined channel catfish. Blood samples were collected for 72 h, and resulting FBZ plasma concentrations were pharmacokinetically modelled. Following intravenous administration t 1/2 alpha was 0.51 h, t 1/2 beta was 16.8 h, body clearance (C1B) was 0.0598 L/kg/h, and Vd (area) was 1.45 L/kg. After oral administration the t 1/2 (abs) was 1.47 h, the t 1/2 beta was 20.1 h, and the tlag was 0.1 h. Following oral administration of 5 mg FBZ/kg body weight, the following tissues and body fluids were sampled for concentrations of FBZ, oxfendazole (FBZ-SO), sulphone metabolite (FBZ-SO2) and hydroxy metabolite (FBZ-OH): liver, posterior kidney, fat, muscle, bowel contents and urine. Fenbendazole was detected in the highest concentrations in abdominal fat, whereas oxfendazole was found primarily in the kidney, liver and abdominal fat. The sulphone metabolite was detected only in urine and bowel contents, while the hydroxy metabolite was found most often in the liver and abdominal fat samples.

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The pharmacokinetics of fenbendazole and oxfendazole in cattle

Cited by 53 publications

References 9 publications

The bioavailability of febantel in dehydrated camels

The bioavailability of febantel in dehydrated camels

Review of methodology for the determination of benzimidazole residues in biological matrices

Pharmacokinetics and metabolism of fenbendazole in channel catfish

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