The perifollicular zone of the spleen as a distributor and filter of                    blood components

Sasou, Shunichi

doi:10.3960/jslrt.20038

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…Splenic congestion is common without any apparent cause and is seen as an excessive accumulation of erythrocytes in the red pulp sinus. There are many causes of splenic congestion in Wistar rats including bacterial infection, cardiovascular disease, mononuclear cell leukemia, erythrocyte damage, euthanasia methods and necropsy procedures [18] , [19] . In this study, focal and multifocal congestion of the spleen was observed after the administration of various doses of pulp-out.…”

Section: Discussionmentioning

confidence: 99%

Acute toxicity potential and impact on periodontal and periapical tissue of Pulp Out: A paste contained jatropha, sidaguri, and melittin

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Acute toxicity potential and impact on periodontal and periapical tissue of Pulp Out: A paste contained jatropha, sidaguri, and melittin

et al. 2022

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“…[ 49 ] The reticular frameworks in the spleen slow down the rate of blood flow, which facilitates the recognition and uptake of foreign antigens by the resident immune cells. [ 50 ] Most importantly, as the largest individual lymphoid organ in the human body, the spleen stores approximately one‐third of the total circulating lymphocytes, leading to the fast migration and activation of immune cells through the spleen at any given time, [ 47 ] together with other functions including erythrocyte clearance and extramedullary hematopoiesis. [ 51 ]…”

Section: Significance Of Spleen‐targeting Vaccinationmentioning

confidence: 99%

Recent Advances of Emerging Spleen‐Targeting Nanovaccines for Immunotherapy

Wang

Tang

et al. 2023

Adv Healthcare Materials

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Vaccines provide a powerful tool to modulate the immune system for human disease prevention and treatment. Classical vaccines mainly initiate immune responses in the lymph nodes (LNs) after subcutaneous injection. However, some vaccines suffer from inefficient delivery of antigens to LNs, undesired inflammation, and slow immune induction when encountering the rapid proliferation of tumors. Alternatively, the spleen, as the largest secondary lymphoid organ with a high density of antigen‐presenting cells (APCs) and lymphocytes, acts as an emerging target organ for vaccinations in the body. Upon intravenous administration, the rationally designed spleen‐targeting nanovaccines can be internalized by the APCs in the spleen to induce selective antigen presentation to T and B cells in their specific sub‐regions, thereby rapidly boosting durable cellular and humoral immunity. Herein, the recent advances of spleen‐targeting nanovaccines for immunotherapy based on the anatomical architectures and functional zones of the spleen, as well as their limitations and perspectives for clinical applications are systematically summarized. The aim is to emphasize the design of innovative nanovaccines for enhanced immunotherapy of intractable diseases in the future.

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“…Лимфоциты в массе своей средние, с округлыми бледными ядрами, которые содержат одно или два ядрышка, и значительным количеством пиронинофильной цитоплазмы. Глубокие отделы ПАЛМ и лимфоидные узелки полностью покрыты маргинальной зоной [38], и между ними четко выражен краевой синус [46,47]. У человека маргинальная зона селезенки располагается только вокруг лимфоидных узелков, а вокруг ПАЛМ практически отсутствует.…”

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Functional Morphology of the Immune Structures of the Spleen Under the Influence of Damaging Factors

Alexeeva

Kvaratskheliya

Sokolov

et al. 2021

Žurnal anatomii i gistopatologii

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In recent years, interest in the study of the morphological and functional characteristics of the organs of the immune system has grown significantly. The immune system makes a significant contribution to the processes of homeostasis and maintaining the health of the organism. Immunity determines the state of the body's resistance to infectious factors. At the same time, the spleen is of particular interest as an immune organ, since the immune system of humans and animals is one of the most sensitive systems of the body, which quickly reacts to any influences. The article presents a literature review devoted to modern concepts of the morphofunctional organization of the spleen in connection with the functions performed, as well as the influence of damaging factors on changes in the morphofunctional parameters of the components of the spleen.

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The perifollicular zone of the spleen as a distributor and filter of blood components

Cited by 3 publications

References 4 publications

Acute toxicity potential and impact on periodontal and periapical tissue of Pulp Out: A paste contained jatropha, sidaguri, and melittin

Acute toxicity potential and impact on periodontal and periapical tissue of Pulp Out: A paste contained jatropha, sidaguri, and melittin

Recent Advances of Emerging Spleen‐Targeting Nanovaccines for Immunotherapy

Functional Morphology of the Immune Structures of the Spleen Under the Influence of Damaging Factors

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