The performance of an orthosilicic acid-releasing silica gel fiber fleece in wound healing

Grotheer, Vera; Goergens, Maria; Fuchs, Paul Christian; Dunda, Sebastian E.; Pallua, Norbert; Windolf, Joachim; Suschek, Christoph V.

doi:10.1016/j.biomaterials.2013.06.012

Cited by 21 publications

(21 citation statements)

References 53 publications

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“…Similarly, Reffitt et al showed increased type 1 collagen, alkaline phosphatase, and osteocalcin synthesis in osteoblast-like cell lines, MG-63 and HCCl [6]. Also, Grotheer et al showed that OSA-releasing hydrogel decreased the inflammatory response and aided chronic wound recovery by inhibiting NF- κ B expression or enhancing I κ B, NF- κ B-inhibiting protein [11]. …”

Section: Discussionmentioning

confidence: 99%

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Pigmentation Effect of Rice Bran Extracted Minerals Comprising Soluble Silicic Acids

Jang

Seo

2016

Evidence-Based Complementary and Alternative Medicine

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Our investigation focused on identifying melanogenesis effect of soluble minerals in rice bran ash extract (RBE) which include orthosilicic acid (OSA). Melanocytes were apparently normal in terms of morphology. It was, however, shown that they were stressed a little in the RBE and OSA added media in aspect of LDH activity. Melanin synthesis and intracellular tyrosinase activity were increased by treatment of RBE which is similar to that of OSA. The Western blotting results showed that TRP-1, tyrosinase, and MITF expression levels were 2-3 times higher in the OSA and RBE groups compared to the control group which promoted melanin synthesis through CREB phosphorylation. Moreover, histology and immunohistochemistry were shown to have similar result to that of protein expression. As a result, minerals which comprise orthosilicic acid has the potential to promote melanogenesis and both RBE and OSA have similar cell viability, protein expression, and immunostaining results, suggesting that RBE comprises specific minerals which promote melanin synthesis through increasing of MITF and CREB phosphorylation. Therefore, RBE could be used as a novel therapeutic approach to combat melanin deficiency related diseases by stimulating melanocytes via its soluble Si and mineral components.

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Section: Discussionmentioning

confidence: 99%

“…Also, Grotheer et al showed that OSA had anti-inflammatory properties in chronic wounds [11] and Barel et al reported that the positive effects of OSA, on skin, hair, and nails, increased with the increase in hydroxyproline concentration in the dermis [12]. …”

Section: Introductionmentioning

confidence: 99%

Pigmentation Effect of Rice Bran Extracted Minerals Comprising Soluble Silicic Acids

Jang

Seo

2016

Evidence-Based Complementary and Alternative Medicine

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“…PSi has been widely investigated for biomedical applications due to its biocompatibility and flexibility in loading different types of cargos. 27,28 Moreover, its main degradation product, orthosilicic acid, has also been known to favor the cutaneous traumatic healing, [29][30][31] thus making PSi an attractive candidate for DFU application. POD encapsulation can effectively block accessible pores of PSi, thus preventing a potent burst release of the drug.…”

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confidence: 99%

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Liu

et al. 2019

Mater. Horiz.

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“…Based on pharmacokinetic and histological analysis in pre-clinical skin wound healing studies in mini pigs, SGF is progressively degraded by hydrolysis during the healing response and replaced by host granulation tissue within 3-13 weeks. The terminal decomposition product is orthosilicic acid [8]. The SGF material degrades slower compared to known biodegradable wound matrices which are based on collagen, cellulosis or polyglycolic acid gels.…”

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confidence: 99%

Randomized standard-of-care-controlled trial of a silica gel fibre matrix in the treatment of chronic venous leg ulcers

Brown

Augustin

Jünger

et al. 2014

European Journal of Dermatology

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Eming SA. Randomized standard-of-care-controlled trial of a silica gel fibre matrix in the treatment of chronic venous leg ulcers. Eur J Dermatol 2014; 24(2): 210-6Background: Chronic venous leg ulcers (CVU) are a common, unresolved medical problem. Silica gel fibre (SGF) is a novel biodegradable inorganic material developed to serve as a carrier substrate for the local release of pharmaceutical agents facilitating tissue repair. Objectives: To assess the performance and safety of SGF in subjects with CVU. Methods: Open, randomized, standard-of-care-controlled, multi-centre trial. Subjects (ITT 120 patients) received either SGF in addition to standard treatment or standard-of-care treatment (S-o-C) alone. The primary performance variable was the time to healing of the target ulcer until the end of a 12 week treatment period. Results: SGF was well tolerated. Mean time to healing up to week 12 was 85.62 days for the SGF group (SE ± 1.5) and 79.66 days for the S-o-C group (SE ± 1.77) (p-value = 0.217). There was no statistically relevant difference regarding the incidence of complete healing of the target ulcers by weeks 12 and 24 between the SGF and the S-o-C groups (p-value >0.05). Conclusion: SGF is well tolerated and offers a promising perspective as a carrier substrate for the local release of active pharmaceutical agents into the wound site to promote tissue repair.Key words: biodegradable matrix, silica gel fibre matrix, venous ulcer * Registration number and name of trial registry: Study number SGF271-01, ClinicalTrials.gov identifier: NCT00998673. Study title "Randomized standard-of-care-controlled trial of a SGF wound dressing in the treatment of chronic venous leg ulcers". Information of trial protocol:

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The performance of an orthosilicic acid-releasing silica gel fiber fleece in wound healing

Cited by 21 publications

References 53 publications

Pigmentation Effect of Rice Bran Extracted Minerals Comprising Soluble Silicic Acids

Pigmentation Effect of Rice Bran Extracted Minerals Comprising Soluble Silicic Acids

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Randomized standard-of-care-controlled trial of a silica gel fibre matrix in the treatment of chronic venous leg ulcers

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