The performance of a small-calibre graft for vascular reconstructions in a senescent sheep model

Electrospun poly(l-lactide-co-caprolactone)–collagen–chitosan vascular graft in a canine femoral artery model

“…8A and B display the surrounding tissue with oriented structure (birefringent yellow / orange) in the autologous and P(LLA-CL)/COL/CS-heparin graft, demonstrating the presence of mature Type I collagen fibers. 3,39 In comparison, the blocked P(LLA-CL)-heparin graft showed much less collagen existence and the surrounding structure was random and promiscuous (Fig. 8C).…”

Next generation covered stents made from nanocomposite materials: A complete assessment of uniformity, integrity and biomechanical properties

“…As mentioned previously, POSS-PCU has a proven potential in various biomedical application including cardiovascular implants 15,35,36 . In this study the non-thrombogenicity of POSS-PCU was compared to ePTFE and CoCr BMS, which are common candidates of materials of synthetic covered stents in the market 4 .…”

“…The incorporation of POSS nanoparticles creates an inherent surface nanotopography of the material. POSS-PCU has already undergone rigorous testing in vitro and in vivo for surface and mechanical properties 8,11,12 , biocompatibility 13 , stem cell differentiation capability 14 and haemocompatibility 11,15 . In addition POSS-PCU has been applied for many application including facial organs 16 and is undergoing clinical trial for vascular access graft.…”

Nanotopography and Plasma Treatment: Redesigning the Surface for Vascular Graft Endothelialisation

“…4e6 Despite these advantages, recent large animal studies conducted to Good Laboratory Practice (GLP) standards, have shown that after insertion as a carotid interposition graft and subsequent explantation there is an incomplete endothelialisation within the graft. 7 This raises concern in terms of the longterm patency potential of the graft and has led us to consider other techniques and methods that may promote endothelialisation.…”