Electrospun poly(<scp>l</scp>-lactide-co-caprolactone)–collagen–chitosan vascular graft in a canine femoral artery model

Wu, Tong; Jiang, Bojie; Wang, Yuanfei; Yin, Anlin; Huang, Chen; Wang, Sheng; Mo, Xiumei

doi:10.1039/c5tb00599j

Cited by 37 publications

(22 citation statements)

References 40 publications

(67 reference statements)

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“…For the PLCL fibers (S3), two features at 2948 and 1757 cm -1 can be attributed to the stretching of -CH3 and C=O groups, respectively. The stretching of the C-O-C moiety leads to other two peaks at 1183 and 1093 cm -1 [18]. The spectrum for CIF exhibits peaks at 3042 cm -1 (O-H stretching), 1626 cm -1 (C=O stretching), and numerous bands between 1582 and 1495 cm -1 from stretching vibrations of the benzene ring [47].…”

Section: X-ray Diffractionmentioning

confidence: 99%

“…Moreover, the biocompatibility is enhanced by an increasing content of PLCL. This is expected to result from the greater cytocompatibility of PLCL than PNIPAAm; PLCL is widely known to be highly biocompatible [18,69].…”

Section: Biocompatibilitymentioning

confidence: 99%

“…The use of electrospun PLCL scaffolds has been widely investigated in tissue regeneration [18,19]), but has attracted much less attention in the context of wound dressing materials.…”

Section: Introductionmentioning

confidence: 99%

“…They were then imaged using SEM at a voltage of 10 kV. The average fiber diameter for each sample was calculated by measuring approximately 100 fibers in SEM images, using the ImageJ software (National Institutes of Health, USA)[50].2.6 Further characterizationCharacterization was undertaken following the best-practice reported in the literature[1,3,10,17,18,50]. X-ray diffraction (XRD) was performed on a D/Max-BR diffractometer (Rigaku, Japan).…”

mentioning

confidence: 99%

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Poly(N-isopropylacrylamide)/poly(l-lactic acid-co-ɛ-caprolactone) fibers loaded with ciprofloxacin as wound dressing materials

Williams²,

et al. 2017

Materials Science and Engineering: C

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In this work, we aimed to develop new materials to reduce the secondary injuries which can be imparted when replacing wound dressings. Electrospun fibers based on the thermoresponsive polymer poly(N-isopropylacrylamide) (PNIPAAm), poly(l-lactic acid-co-ɛ-caprolactone) (PLCL), and the antibiotic ciprofloxacin (CIF) were prepared. The water contact angle of fibers made from a blend of PNIPAAm and PLCL changed dramatically when the temperature was increased above 32°C. Sustained release of CIF from the formulations was observed over >200h. Moreover, L929 fibroblasts could proliferate on the fibers, indicating their biocompatibility. The CIF-loaded fibers were found to have potent antibacterial activity against E. coli and S. aureus. In vivo tests on rats indicated that CIF-loaded thermosensitive fibers have enhanced healing performance compared to CIF-loaded PLCL fibers or a commercial gauze. Electrospun PNIPAAm/PLCL fibers loaded with CIF thus have great promise in the development of new wound dressing materials.

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Section: X-ray Diffractionmentioning

confidence: 99%

Section: Biocompatibilitymentioning

confidence: 99%

“…The use of electrospun PLCL scaffolds has been widely investigated in tissue regeneration [18,19]), but has attracted much less attention in the context of wound dressing materials.…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Poly(N-isopropylacrylamide)/poly(l-lactic acid-co-ɛ-caprolactone) fibers loaded with ciprofloxacin as wound dressing materials

Williams²,

et al. 2017

Materials Science and Engineering: C

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“…CaES also allows for the incorporation of bioactive substances in the core structure which can then undergo controlled release. In one study, individual fibers were spun with heparin as the core component and a surrounding PLCL/collagen/chitosan shell . ESVGs made from these fibers showed a sustained release of heparin for more than 20 d, resulting in the inhibition of thrombosis and increased graft patency 8 weeks after implantation.…”

Section: Engineering‐based Techniquesmentioning

confidence: 99%

Fabrication Techniques for Vascular and Vascularized Tissue Engineering

Wang

Mithieux

Weiss

2019

Adv Healthcare Materials

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Impaired or damaged blood vessels can occur at all levels in the hierarchy of vascular systems from large vasculatures such as arteries and veins to meso‐ and microvasculatures such as arterioles, venules, and capillary networks. Vascular tissue engineering has become a promising approach for fabricating small‐diameter vascular grafts for occlusive arteries. Vascularized tissue engineering aims to fabricate meso‐ and microvasculatures for the prevascularization of engineered tissues and organs. The ideal small‐diameter vascular graft is biocompatible, bridgeable, and mechanically robust to maintain patency while promoting tissue remodeling. The desirable fabricated meso‐ and microvasculatures should rapidly integrate with the host blood vessels and allow nutrient and waste exchange throughout the construct after implantation. A number of techniques used, including engineering‐based and cell‐based approaches, to fabricate these synthetic vasculatures are herein explored, as well as the techniques developed to fabricate hierarchical structures that comprise multiple levels of vasculature.

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Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

Zhao

Feng

2020

Adv Healthcare Materials

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Cardiovascular devices have been widely applied in the clinical treatment of cardiovascular diseases. However, poor hemocompatibility and slow endothelialization on their surface still exist. Numerous surface engineering strategies have mainly sought to modify the device surface through physical, chemical, and biological approaches to improve surface hemocompatibility and endothelialization. The alteration of physical characteristics and pattern topographies brings some hopeful outcomes and plays a notable role in this respect. The chemical and biological approaches can provide potential signs of success in the endothelialization of vascular device surfaces. They usually involve therapeutic drugs, specific peptides, adhesive proteins, antibodies, growth factors and nitric oxide (NO) donors. The gene engineering can enhance the proliferation, growth, and migration of vascular cells, thus boosting the endothelialization. In this review, the surface engineering strategies are highlighted and summarized to improve hemocompatibility and rapid endothelialization on the cardiovascular devices. The potential outlook is also briefly discussed to help guide endothelialization strategies and inspire further innovations. It is hoped that this review can assist with the surface engineering of cardiovascular devices and promote future advancements in this emerging research field.

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Electrospun poly(l-lactide-co-caprolactone)–collagen–chitosan vascular graft in a canine femoral artery model

Cited by 37 publications

References 40 publications

Poly(N-isopropylacrylamide)/poly(l-lactic acid-co-ɛ-caprolactone) fibers loaded with ciprofloxacin as wound dressing materials

Poly(N-isopropylacrylamide)/poly(l-lactic acid-co-ɛ-caprolactone) fibers loaded with ciprofloxacin as wound dressing materials

Fabrication Techniques for Vascular and Vascularized Tissue Engineering

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

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