The percutaneous needle biopsy is safe and recommended in the diagnosis of musculoskeletal masses

Welker, James A.; Henshaw, Robert M.; Jelinek, James S.; Shmookler, Barry M.; Malawer, Martin M.

doi:10.1002/1097-0142(20001215)89:12<2677::aid-cncr22>3.0.co;2-l

Cited by 212 publications

(160 citation statements)

References 17 publications

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“…For instance, Rimondi et al described 22 complications in 2027 CT-guided biopsies, which represents a complication rate of 1.1 % [25]. For comparison in open biopsy the complication rate may be as high as 16 % [26]. The very low complication rate observed in our study was in accordance with the recent data in the literature.…”

supporting

confidence: 90%

CT-Guided Percutaneous Spine Biopsy in Suspected Infection or Malignancy: A Study of 214 Patients

Rehm

Veith

Akbar

et al. 2016

Fortschr Röntgenstr

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Zusammenfassung ▼Ziel: Retrospektive Bestimmung der Effektivität und Genauigkeit von CT-gesteuerten perkutanen Biopsien von malignen und entzündlichen Verän-derungen der Wirbelsäule und Bestimmung der Reliabilität der prä-interventionell durchgeführ-ten CT-und MRT-Bildgebung. Abstract ▼Purpose: To retrospectively determine the effectiveness and accuracy of CT-guided percutaneous biopsy of malignant and inflammatory bone lesions of the spine and to assess the reliability of pre-biopsy CT and MRI. Materials and Methods: 214 patients with lesions of the spine, which were suspicious either for being malignant or inflammatory, underwent CT-guided biopsy for pathological and/or microbiological detection. Biopsy samples were sent for histological examination in 128/214 patients, for microbiological analysis in 17/214 patients and for both analyses in 69/214 patients. Retrospectively, the diagnostic accuracy and sensitivity/specificity of the pre-interventional imaging (CT and MRI) were determined. In addition, the influence of the biopsy on subsequent patient management was assessed. Results: The accuracy was 94.4 % for histopathological analysis and 97.7 % for microbiological analysis. In 25 % of cases the microbiological analysis revealed an underlying pathogen that was not significantly affected by pre-biopsy antibiotic therapy. The sensitivity/specificity of the pre-biopsy crosssectional imaging concerning suspected malignancy was 69 %/78 %. For suspected infection, the sensitivity/specificity of pre-biopsy imaging was 81 %/ 44 %. In 52 % of all cases, the biopsy result changed subsequent patient management. Conclusion: Percutaneous CT-guided spine biopsy is a useful and reliable diagnostic procedure to establish a definitive diagnosis but with a relatively low yield of microorganisms in the case of infection.

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supporting

confidence: 90%

CT-Guided Percutaneous Spine Biopsy in Suspected Infection or Malignancy: A Study of 214 Patients

Rehm

Veith

Akbar

et al. 2016

Fortschr Röntgenstr

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“…CNB achieved an accuracy rate of 93% for nature of lesions, 83% for specific diagnosis, 83% for histologic grading, and 90% for histologic typing. Both biopsy methods have a higher diagnostic accuracy rate for high-grade tumors than for low-grade or benign lesions in determining the nature, specific diagnosis, and histologic grading [19].…”

Section: Discussionmentioning

confidence: 99%

“…In case of deep lesions, for example in the pelvis or spine, needle biopsies are challenging procedures [16]. In these cases, the aid of computed tomography (CT)-guidance has further increased accuracy, reduced complications and therefore has now become the procedure of choice [5,8,9,11,[17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Percutaneous CT-guided biopsy of the spine: results of 430 biopsies

et al. 2008

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Biopsies of lesions in the spine are often challenging procedures with significant risk of complications. CT-guided needle biopsies could lower these risks but uncertainties still exist about the diagnostic accuracy. Aim of this retrospective study was to evaluate the diagnostic accuracy of CT-guided needle biopsies for bone lesions of the spine. We retrieved the results of 430 core needle biopsies carried out over the past fifteen years at the authors' institute and examined the results obtained. Of the 430 biopsies performed, in 401 cases the right diagnosis was made with the first CT-guided needle biopsy (93.3% accuracy rate). Highest accuracy rates were obtained in primary and secondary malignant lesions. Most false negative results were found in cervical lesions and in benign, pseudotumoral, inflammatory, and systemic pathologies. There were only 9 complications (5 transient paresis, 4 haematomas that resolved spontaneously) that had no influence on the treatment strategy, nor on the patient's outcome. In conclusion we can assert that this technique is reliable and safe and should be considered the gold standard in biopsies of the spine.

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“…The aforementioned good results of core needle biopsies come from referral centers [2,[12][13][14], where there is vast experience with sarcoma treatment and hence with the diagnostic work-up too. The limited sensitivity of needle biopsies in the present population based cohort is most likely explained by less experience with the collection of specimens, and less experience with the evaluation of the retrieved material.…”

Section: A C C E P T E D Article In Pressmentioning

confidence: 99%

Current pathology work-up of extremity soft tissue sarcomas, evaluation of the validity of different techniques

Verheijen

Witjes

Gorp

et al. 2010

European Journal of Surgical Oncology (EJSO)

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Objective: In patients with extremity soft tissue sarcomas (STS) a correct histopathological diagnosis is considered important before surgical treatment. We evaluated the preoperative use and sensitivity of the various pathology techniques. Methods:In a population based study in patients operated for a newly diagnosed extremity STS between January 2000 and December 2003 the preoperative pathology work-up was evaluated. Data were retrieved from a national pathology database (PALGA). The sensitivity of the three techniques was assessed considering an examination affirmative when the conclusion of the pathology report stated the presence of mesenchymal malignancy.Results: The pathology reports of 573 patients were identified in the database. In 177 patients (31%) no pathology examination was done before resection of the tumour. In the remaining 396 patients the pathology procedure of first choice had been an incisional biopsy (IB) in 195 patients (49 percent), a core needle biopsy (CNB) in 90 patients (23 percent) and a fine needle aspiration (FNA) in 111 patients (28 percent). An affirmative diagnosis was established in 95% of the patients following an IB, in 78% after a CNB and in 38% following FNA. After an initial CNB an additional IB was performed in 18 of the 90 patients improving the yield to 89% After an initial FNA a subsequent histological biopsy was done in 53 of the 111 patients, increasing the sensitivity to 71%. Conclusions:In this population based study in patients treated for extremity STS, the proportion of patients operated without preoperative pathology evaluation was high. In the remaining patients an incisional biopsy was still the most commonly performed technique with the highest yield.

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The percutaneous needle biopsy is safe and recommended in the diagnosis of musculoskeletal masses

Cited by 212 publications

References 17 publications

CT-Guided Percutaneous Spine Biopsy in Suspected Infection or Malignancy: A Study of 214 Patients

CT-Guided Percutaneous Spine Biopsy in Suspected Infection or Malignancy: A Study of 214 Patients

Percutaneous CT-guided biopsy of the spine: results of 430 biopsies

Current pathology work-up of extremity soft tissue sarcomas, evaluation of the validity of different techniques

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