The oxidative stress index increases among patients with hyperemesis gravidarum but not in normal pregnancies

Yılmaz, Canan; Özgü-Erdinç, A. Seval; Demirtaş, Canan; Öztürk, Gülfer; Erkaya, Salım; Uygur, Dilek

doi:10.1179/1351000214y.0000000110

Cited by 16 publications

(14 citation statements)

References 44 publications

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“…It is well documented that oxidative stress prevails during first trimester of pregnancy due to increased reactive oxygen species that influ-Open Journal of Obstetrics and Gynecology ence a number of functions such as angiogenesis, remodelling of the spiral arteries, cell permeability and vascularisation during embryogenesis and placental development [45]. This oxidative stress has been shown to be compensated by the parallel elevation of antioxidant defences and a defective response in this oxidant stimulus may be an essential component in the aetiology of preeclampsia [46], thus an intricate balance between oxidants and antioxidants is vital in early pregnancy [47].…”

Section: Discussionmentioning

confidence: 99%

Maternal Serum Biochemical Indicators of Trophoblastic Cell and Endothelial Function at First Trimester of Pregnancy

Gadde¹,

Dayanand²,

Sheela³

2018

OJOG

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Background: Preeclampsia is a worldwide pregnancy complication, and early identification of patients with an increased risk is one of the key goals in obstetrics. First trimester screening is crucial over the second trimester for understanding the early onset of the disorder, with basal levels of the biochemical parameters associated with the underlying placentation process. Objective: The study aims to assess the levels of serum biochemical markers in pregnant women at first trimester, to evaluate statistical significance and correlation of the values in support of trophoblastic cell integrity, endothelial function and oxidative stress. Materials and Methods: A longitudinal study was conducted on 86 pregnant women of age group 20 -35 years, Primigravida with singleton pregnancy who visited prenatal check up between 11 -13 weeks of gestation. Maternal sera was collected for screening Placental protein 13 (PP13), Caspase 3, Asymmetric dimethylarginine (ADMA), Nitric oxide (NO) by ELISA. Xanthine oxidase (XO) activity was assayed spectrophotometrically. Calcium and Uric acid (UA) were measured by dry chemistry analyser. Results: The mean ± SD values for mean arterial pressure (MAP) are 108.4 ± 18.9, UA 2.01 ± 0.85, Total oxidant status (TOS) 12.83 ± 5.17, Total antioxidant capacity (TAC) 24.

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Section: Discussionmentioning

confidence: 99%

Maternal Serum Biochemical Indicators of Trophoblastic Cell and Endothelial Function at First Trimester of Pregnancy

Gadde¹,

Dayanand²,

Sheela³

2018

OJOG

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“…Dynamic thiol disulphide homeostasis status has critical roles in antioxidant protection. OS is reported to be involved in the prognosis of various diseases and syndromes including cardiovascular disorders, cancer, allergy, some neurological disorders, diabetes, and diabetic retinopathy ( 8 9 10 ). Colchicine, the gold standard treatment for FMF blocks the release of cytokines and microtubule depolymerization.…”

Section: Introductionmentioning

confidence: 99%

Can the Thiol/Disulfide Imbalance Be a Predictor of Colchicine Resistance in Familial Mediterranean Fever?

et al. 2017

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Familial Mediterranean fever (FMF) is a chronic autoinflammatory condition characterized by fever attacks and recurrent polyserositis. Subclinical inflammation that persists during attack-free periods can result in oxidative stress (OS) damage. Thiol groups bind to reactive oxygen radicals and protect cells and tissues from OS damage. The aim of this study was to investigate the relationship between thiol-disulfide balance and colchicine resistance in FMF patients during an attack or attack-free period. A newly developed spectrophotometric method was used to measure native thiol (NT) and disulfide (DS) levels in FMF patients and an age-sex matched group of healthy controls. NT and DS levels were compared in FMF patients 1) with vs. without colchicine resistance; and 2) during an attack (FMF-AP) vs. attack-free period (FMF-AFP). A total of 118 FMF patients and 60 healthy controls were studied. NT (P < 0.001) and total thiol (TT) (P < 0.001) levels in FMF patients were significantly lower compared to healthy controls. NT (P = 0.030) and TT (P = 0.010) levels of FMF-AP patients were significantly lower than that of FMF-AFP patients. FMF-AP patients had significantly higher DS levels than FMF-AFP patients (P = 0.039). Compared to FMF patients without colchicine resistance, elevated levels of DS (P = 0.019) but not NT (P = 0.620) and TT (P = 0.718) were found in those with colchicine resistance. Thiol-disulfide homeostasis is altered in FMF patients during an attack period and this imbalance may be associated with colchicine resistance.

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“…OS is reported to be involved in many diseases and syndromes. [5][6][7] Nonetheless, until recently in trials aimed at evaluating OS, usually quite complicated methods like high-sensitivity fluorometric high-performance liquid chromatography, 8 capillary electrophoresis with laserinduced fluorescence detection 9 and enzymatic recycling, 10 and substances such as 5,5 ′ -dithiobis-(2-nitrobenzoic acid) (DTNB) 11 and dithiodipyridine (4-DPS) 12 were used.…”

Section: Introductionmentioning

confidence: 99%

Thiol/disulphide homeostasis in pregnant women with Familial Mediterranean fever

et al. 2016

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The oxidative stress index increases among patients with hyperemesis gravidarum but not in normal pregnancies

Abstract: The present study supports the role of systemic oxidative stress, reflected by an imbalance between the TOS and TAS, in patients with HG. Our findings distinguish the mechanism underlying oxidative stress to result from reduction of antioxidants rather than an increase in oxidants.

Cited by 16 publications

References 44 publications

Maternal Serum Biochemical Indicators of Trophoblastic Cell and Endothelial Function at First Trimester of Pregnancy

Maternal Serum Biochemical Indicators of Trophoblastic Cell and Endothelial Function at First Trimester of Pregnancy

Can the Thiol/Disulfide Imbalance Be a Predictor of Colchicine Resistance in Familial Mediterranean Fever?

Thiol/disulphide homeostasis in pregnant women with Familial Mediterranean fever

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