The ototoxic effects of kanamycin sulfate in infants and children

Yow, Martha D.; Tengg, Nic E.; Bangs, Jack L.; Bangs, Tina E.; Stephenson, Winnie B.

doi:10.1016/s0022-3476(62)80041-9

Cited by 27 publications

(4 citation statements)

References 10 publications

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“…If the concentration seemed to rise, the dose could be lowered and an antibacterial level still sufficient was maintained. These results differ even more from those of Sanders et al (1967) and Yow et al (1962 , but the doses used in our material are smaller and the patients were monitored more ade quately.…”

Section: Discussioncontrasting

confidence: 74%

“…The serum kanamycin levels of these patients are not reported. The serum level varies greatly, depending on the renal function, and thus may rise to toxic limits ( Yow et al, 1962). The control age of 4 -5 years is rather low, if we want to achieve reliable results.…”

Section: Introductionmentioning

confidence: 99%

“…The first report by Yow et al (1962) presents only 8 patients. The daily dose ranged from 10 to 100 mg/kg/day, and the treatment lasted 5 -9 5 days.…”

Section: Introductionmentioning

confidence: 99%

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Results of Hearing Testing at 7-Year Follow-Up of Kanamycin-Treated Newborn Infants

Rahko¹,

Ikonen²,

Janas³

et al. 1978

ORL

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A follow-up study 7–8 years after kanamycin treatment of 83 newborn infants in the Tampere University Central Hospital is described. The Apgar scores ranged from 1 to 10, about half of the patients being premature. Only in 1 case (1.2%) a slight bilateral high-tone loss was found. This patient’s birth had been complicated by ablation of the placenta with subsequent cesarean section and he had neonatal sepsis as well. The cause of this hearing defect is thus not necessarily the use of kanamycin. Because of the extended use of reserve antibiotics, microorganisms resistant to modern antibiotics may necessitate in some vital cases the use of kanamycin. Our results indicate that, if serum concentrations are monitored adequately, the use of kanamycin does not necessarily result in a hearing defect.

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Section: Discussioncontrasting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Results of Hearing Testing at 7-Year Follow-Up of Kanamycin-Treated Newborn Infants

Rahko¹,

Ikonen²,

Janas³

et al. 1978

ORL

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“…The use of aminoglycosides has been studied previously, first by Yow et al 14 in 1962, who showed that the risk of hearing loss was increased with cumulative kanamycin doses above 500 mg/kg with normal renal function, seeming to confirm adult and animal evidence for ototoxicity and interaction between aminoglycoside and other factors, such as acoustic trauma. Suggestions of aminoglycoside toxicity12 13 have not been confirmed, and a prospective study comparing infants treated with kanamycin and gentamicin with unexposed controls failed to show any association despite a large trial group 15.…”

Section: Discussionmentioning

confidence: 95%

Sensorineural hearing loss and prematurity

Marlow

Hunt

Marlow

2000

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Objective-To elucidate clinical antecedents of sensorineural hearing loss (SNHL) in very preterm infants. Design-Case-control study. Subjects-Fifteen children < 33 weeks' gestation with significant SNHL born between 1 January 1990 and 31 December 1994, detected within 9 months of birth, and 30 matched control children. Methodology-Perinatal variables in the two groups were compared using nonparametric tests and conditional logistic regression (EGRET). Results-Median Conclusions-Pretermchildren with SNHL required more intensive care in the perinatal period and developed more neurological complications than controls. Among very preterm babies, the coexistence of risk factors for hearing loss may be more important than the individual factors themselves. (Arch Dis Child Fetal Neonatal Ed 2000;82:F141-F144)

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