Increased Ototoxicity in Both Young and Old Mice

Neuronal erythropoietin overexpression is protective against kanamycin-induced hearing loss in mice

“…We observed slightly higher survival of OHCs compared to the published original data on the mouse model of ototoxicity used in the present study [22]. One reason may be the older age of the animals used in our study, rendering the mice less susceptible to ototoxic damage [30,31]. Our results are in agreement with the ABR threshold shifts obtained, which were also slightly smaller than originally published for this mouse model [22].…”

Expression of Fractalkine Receptor CX3CR1 on Cochlear Macrophages Influences Survival of Hair Cells Following Ototoxic Injury

“…In the central nervous system, CX3CL1 and CX3CR1 have been shown to modulate microglial activation and neurotoxicity in various conditions of brain injury (Harrison et al 1998;Limatola et al 2005a;Cardona et al 2006). Our current study confirms high frequency hearing loss and degeneration of high frequency outer hair cells in mammals exposed to kanamycin (Henry et al 1981;Chen and Saunders 1983;Wu et al 2001;Jiang et al 2006;Taleb et al 2009). Additionally, we demonstrate that CX3CR1 knockout mice suffer more extensive hair cell loss and hearing loss when compared to CX3CR1-expressing mice.…”

Translational Research in Audiology

“…Consistent with these findings, young adult (1-2 months old) C57Blk/6J, CBA/CaJ, and Balb/CJ mice were more likely to develop noise-induced permanent threshold shifts than 5-7 month-old mice [60]. Similarly, susceptibility to ototoxic damage is age-dependent, and mice are most sensitive to drugs such as kanamycin during the first month of life [61,62]. Furthermore, susceptibility to drug-induced hearing loss depends on the exposure time and dose [63][64][65].…”