Sensorineural hearing loss and prematurity

Marlow, Elaine S; Hunt, Linda; Marlow, Neil

doi:10.1136/fn.82.2.f141

Cited by 93 publications

(68 citation statements)

References 17 publications

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“…(Tabela 1) A incidência de meningite na literatura varia de 6 a 22%. 1 [16][17][18][19] Diante desses dados, observa-se que algumas das principais causas de perda auditiva na infância como rubéola, meningite e ototoxicidade, são passíveis de prevenção. Utilizando-se medidas simples como programas de vacinação, orientação pré-natal adequada, maior informação de profissionais de saúde quanto à prescrição de medicações ototóxicas, pode-se realizar a profilaxia da deficiência auditiva.…”

Section: Resultsunclassified

Análise das principais etiologias de deficiência auditiva em Escola Especial "Anne Sullivan"

Cecatto

Garcia

Costa

et al. 2003

Rev. Bras. Otorrinolaringol.

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Obj etivo: Determinar as principais etiologias de deficiência auditiva em estudantes da Escola de Ensino Especial para surdos "Anne Sullivan" em São Caetano do Sul e comparar com os dados da literatura mundial. Forma de estudo: Estudo retrospectivo Material e método: Cento e trinta e um alunos da escola no ano de 2001 foram avaliados através de análise de seus prontuários, levando-se em conta dados de anamnese com a família, exame físico otorrinolaringológi-co, avaliação fonoaudiológica e psicológica. Resultados: Dos 131 pacientes, 67 (51%) eram do sexo masculino e 64 (49%) do sexo feminino. A perda auditiva sensorioneural foi a mais encontrada, representando 99% dos casos. Quanto ao grau de disacusia, 65% foi classificado como profundo. Quanto à etiologia, 24% foi classificada como desconhecida e das causas identificáveis a rubéola congênita foi a mais encontrada (22%). Na maioria dos pacientes a suspeita e o diagnóstico foram feitos com 12 meses de idade. Conclusões: A etiologia não definida foi a mais representativa, seguida pela rubéola, e a idade de diagnóstico predominou entre 12 e 30 meses. Aim:The purpose of this study was to determine the etiology of hearing loss in students of "Escola de Ensino Especial Anne Sullivan" at São Caetano do Sul to make a comparison of the results with the literature. Study design: Retrospective study. Material and method: We analyzed the medical history of 131 students in 2001, including the familiar anamnesis, otorhinolaryngological, psychological and audiological examination. Results: In the group, 67 (51%) were males and 64 (49%) females; 99% showed sensorineural hearing loss, 65% classified as profound. Etiological factors: in 24% no cause of hearing impairment could be determined; rubella was found in 22% of the children. The majority of the children had the suspicion and the diagnosis within 12 months old. Conclusions: The undefined etiology was the main finding, followed by congenital rubella. The diagnosis has to be made between 12 and 30 months. Rev Bras Otorrinolaringol. V.69, n.2, 235-40, mar./abr. 2003 ORIGINAL ARTICLE ARTIGO ORIGINAL «« ««Palavras-chave: perda auditiva, surdez, infância, etiologia.

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Section: Resultsunclassified

Análise das principais etiologias de deficiência auditiva em Escola Especial "Anne Sullivan"

Cecatto

Garcia

Costa

et al. 2003

Rev. Bras. Otorrinolaringol.

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“…minimal brain damage and learning disabilities, and visual and hearing deficits. Those who have sensorineural hearing loss develop more neurologic complications than control infants (6). However, there are still controversies regarding early neural development in these babies.…”

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confidence: 99%

Auditory Neural Responses to Click Stimuli of Different Rates in the Brainstem of Very Preterm Babies at Term

2002

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Auditory neural responses to acoustic stimuli of different rates were studied by analyzing changes in brainstem auditory evoked responses (BAER) with increasing repetition rate of clicks, or rate-dependent changes, in 62 very preterm babies (gestation 24 -32 wk). None had perinatal asphyxia or major complications at the time of testing (37-42 wk postconceptional age) to exclude their possible effects on the recorded BAER. As the rate of clicks was increased from 21/s to 51/s and 91/s, I-V interpeak interval in these babies increased similarly to that in normal term neonates. The rate-dependent change decreased significantly in I-III interval, but increased significantly in III-V intervals and III-V/ I-III interval ratio (all p Ͻ 0.01). At all three rates of clicks, the I-V interval, the most commonly used BAER variable, tended to increase slightly but did not differ significantly from the term neonates. The I-III interval decreased significantly at higher click rates (ANOVA p Ͻ 0.05 at 51/s and Ͻ 0.001 at 91/s), whereas the III-V interval and III-V/I-III interval ratio increased significantly at all 21/s, 51/s, and particularly 91/s (p Ͻ 0.01-0.001). No abnormalities were found in wave V amplitude at any rates. These results suggest that very preterm babies have an advanced peripheral development of the brainstem auditory pathway but a retarded central development or central impairment. A nearly normal I-V interval does not exclude a possible abnormality in its subcomponents (I-III and III-V intervals). In babies who have a normal BAER at a conventionally used low rate of clicks, we cannot exclude an abnormal BAER at higher rates. Babies who are born very preterm account for a large proportion of perinatal mortality and are at high risk of neurodevelopmental deficits (1-5). Many of the survivors have long-term neurologic disorders or behavior problems, e.g. minimal brain damage and learning disabilities, and visual and hearing deficits. Those who have sensorineural hearing loss develop more neurologic complications than control infants (6). However, there are still controversies regarding early neural development in these babies. Some investigators reported a delay in development (7-9), whereas others found no apparent abnormality (10, 11). Better understanding of the early development and neurophysiology underlying later disability is important for improving the management of these babies.BAERs represent the electrophysiologic activity of a large number of auditory neurons in the brainstem after transient acoustic stimulation. The responses have been widely used to study auditory function and its development in babies (12)(13)(14)(15)(16)(17)(18). Although most of the previous BAER studies in preterm babies reported no significant abnormalities (12, 18), others reported an increase in BAER wave latencies and intervals, suggesting retarded development (16). To date, none of the previous reports were concentrated on the study of BAER central components in very preterm babies.The neonatal BAER is significantly aff...

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“…In general, aminoglycosides appear well tolerated by newborn infants but administration frequently occurs in the presence of other risk factors for toxic side effects. The co-occurrence of such risks may be the origin of permanent sequelae [9]. There is a suggestion that netilmicin contributes to ototoxicity when used in the presence of other risk factors, such as hyperbilirubinaemia or acidosis [9].…”

Section: Discussionmentioning

confidence: 99%

Use of Once-Daily Netilmicin to Treat Infants with Suspected Sepsis in a Neonatal Intensive Care Unit

Brooks¹,

Marlow

Reeves

et al. 2004

Neonatology

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Once-daily administration of aminoglycoside antibiotics has become the most acceptable dosing schedule for the majority of patients. There are few published data on the impact of post-natal age on aminoglycoside concentrations in preterm infants receiving once-daily dosage regimens. Netilmicin was administered as a once-daily dose of 4 mg/kg. In 141 episodes of suspected sepsis in 123 babies, trough netilmicin concentrations ranged from undetectable to 4.0 mg/l. Netilmicin concentrations were above a level of 2 mg/l in 10.6% of episodes. Netilmicin concentrations decreased with increasing post-natal age and weight. Levels were higher in males compared to females. Increased creatinine concentrations were associated with higher netilmicin concentrations. This study emphasises the importance of post-natal age as a determinant of aminoglycoside concentrations with a once-daily dosing regimen in a neonatal intensive care population. Trough levels should be carefully monitored and consideration given to extending dosage intervals particularly when netilmicin is administered once daily to preterm infants in the first week of life.

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Sensorineural hearing loss and prematurity

Cited by 93 publications

References 17 publications

Análise das principais etiologias de deficiência auditiva em Escola Especial "Anne Sullivan"

Análise das principais etiologias de deficiência auditiva em Escola Especial "Anne Sullivan"

Auditory Neural Responses to Click Stimuli of Different Rates in the Brainstem of Very Preterm Babies at Term

Use of Once-Daily Netilmicin to Treat Infants with Suspected Sepsis in a Neonatal Intensive Care Unit

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