The osteogenic response of mesenchymal stem cells to an injectable PLGA bone regeneration system

Curran, Judith M.; Fawcett, Sandra; Hamilton, Lloyd; Rhodes, Nicholas P.; Rahman, Cheryl V.; Alexander, Morgan R.; Shakesheff, Kevin M.; Hunt, John A.

doi:10.1016/j.biomaterials.2013.08.044

Cited by 46 publications

(37 citation statements)

References 39 publications

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“…However, the WCAs of the PLGA/CNC composite nanofiber membranes were lower than that of the neat PLGA nanofiber membranes Table 1 Static contact angles of neat PLGA nanofiber membranes, and PLGA nanofiber membranes reinforced with CNCs at loadings of 1, 3, 5, and 7 wt.% (n = 3 for each group). [ 37,38]. As noted above, the presence of intermolecular hydrogen bonding within the cellulose chains also helped to improve the hydrophilicity of the composite nanofiber membranes.…”

Section: Hydrophilicity Of the Composite Nanofiber Membranesmentioning

confidence: 83%

Preparation and properties of PLGA nanofiber membranes reinforced with cellulose nanocrystals

Guo

Liu

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Hydrophilicity Of the Composite Nanofiber Membranesmentioning

confidence: 83%

Preparation and properties of PLGA nanofiber membranes reinforced with cellulose nanocrystals

Guo

Liu

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…On the other hand, these techniques are easy and permit incorporation of biological and organic components to achieve a variety of biological functions . The enrichment of the surface with favorite functional groups including OH, NH 2 , and COOH seems to be a promising strategy to influence cellular behavior for TERM purposes . The aminolysis technique is commonly used with EDC/NHS chemistry to introduce primary or secondary NH 2 groups onto the surface of biomaterial .…”

Section: Surface Modification Methodsmentioning

confidence: 99%

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani

Arzaghi

Bayandori

et al. 2019

Adv Materials Inter

306

200

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Surface interaction at the biomaterial–cell interface is essential for a variety of cellular functions, such as adhesion, proliferation, and differentiation. Nevertheless, changes in the biointerface enable to trigger specific cell signaling and result in different cellular responses. In order to manufacture biomaterials with higher functionality, biomaterials containing immobilized bioactive ligands have been widely introduced and employed for tissue engineering and regenerative medicine applications. Moreover, a number of physical and chemical strategies have been used to improve the functionality of biomaterials and specifically at the material interface. Here, the interactions between materials and cells at the interface levels are described. Then, the importance of surface properties in cell function is discussed and recent methods for surface modifications are systematically highlighted. Additionally, the impact of bulk material properties on the cellular responses is briefly reviewed.

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“…Recently, much attention has been paid to microcarriers composed of biodegradable polymers, such as poly(lactide) (PLA), poly(glicolide) (PGA), and their copolymer poly(lactide‐co‐glycolide) (PLGA), since the polymers possess good mechanical properties, low immunogenicity and toxicity, and an adjustable degradation rate . The biodegradable microcarriers not only provide a large number of cells for the field of cell therapy but also can be directly applied on tissue and organ as microcarriers/cells compound without enzyme treatment and harvest . PLGA is one kind of the most promising degradable materials in tissue engineering because their degradation rate can be adjusted by altering the ratio of lactic to glycolic acids .…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Microcarriers of Poly(Lactide-co-Glycolide) and Nano-Hydroxyapatite Decorated with IGF-1 via Polydopamine Coating for Enhancing Cell Proliferation and Osteogenic Differentiation

et al. 2015

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In this study, insulin-like growth factor 1 (IGF-1) was successfully immobilized on the poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) and pure PLGA microcarriers via polydopamine (pDA). The results demonstrated that the pDA layer facilitated simple and highly efficient immobilization of peptides on the microcarriers within 20 min. Mouse adipose-derived stem cells (ADSCs) attachment and proliferation on IGF-1-immobilized microcarriers were much higher than non-immobilized ones. More importantly, the IGF-1-immobilized PLGA/HA microcarriers significantly increased alkaline phosphatase (ALP) activity and expression of osteogenesis-related genes of ADSCs. Therefore, it is considered that the IGF-1-decorated PLGA/HA microcarriers will be of great value in the bone tissue engineering.

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The osteogenic response of mesenchymal stem cells to an injectable PLGA bone regeneration system

Cited by 46 publications

References 39 publications

Preparation and properties of PLGA nanofiber membranes reinforced with cellulose nanocrystals

Preparation and properties of PLGA nanofiber membranes reinforced with cellulose nanocrystals

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Biodegradable Microcarriers of Poly(Lactide-co-Glycolide) and Nano-Hydroxyapatite Decorated with IGF-1 via Polydopamine Coating for Enhancing Cell Proliferation and Osteogenic Differentiation

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