Preparation and properties of PLGA nanofiber membranes reinforced with cellulose nanocrystals

Mo, Yunfei; Guo, Rui; Liu, Jianghui; Lan, Yong; Zhang, Yi; Wang, Xue; Zhang, Yuanming

doi:10.1016/j.colsurfb.2015.05.029

Cited by 97 publications

(48 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As we demonstrated previously [20], PLGA and CNC nanofiber membranes show good cytocompatibility and facilitate fibroblast adhesion, spreading and proliferation. PLGA/CNC nanofiber membranes are novel materials that have not been used previously as NT carriers in diabetic wounds.…”

Section: Introductionsupporting

confidence: 69%

Neurotensin-loaded PLGA/CNC composite nanofiber membranes accelerate diabetic wound healing

Zheng

Liu

Huang

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

Self Cite

View full text Add to dashboard Cite

Diabetic foot ulcers (DFUs) are a threat to human health and can lead to amputation and even death. Recently neurotensin (NT), an inflammatory modulator in wound healing, was found to be beneficial for diabetic wound healing. As we demonstrated previously, polylactide-polyglycolide (PLGA) and cellulose nanocrystals (CNCs) (PLGA/CNC) nanofiber membranes show good cytocompatibility and facilitate fibroblast adhesion, spreading and proliferation. PLGA/CNC nanofiber membranes are novel materials that have not been used previously as NT carriers in diabetic wounds. This study aims to explore the therapeutic efficacy and possible mechanisms of NT-loaded PLGA/CNC nanofiber membranes in full-thickness skin wounds in spontaneously diabetic mice. The results showed that NT could be sustained released from NT-loaded PLGA/CNC composite nanofiber membranes for 2 weeks. NT-loaded PLGA/CNC composite nanofiber membranes induced more rapid healing than other control groups. After NT exposure, the histological scores of the epidermal and dermal regeneration and the ratios of the fibrotic area to the whole area were increased. NT-loaded PLGA/CNC composite nanofiber membranes also decreased the expressions of the inflammatory cytokines IL-1β and IL-6. These results suggest that NT-loaded PLGA/CNC composite nanofiber membranes for sustained delivery of NT should effectively promote tissue regeneration for the treatment of DFUs.

show abstract

Section: Introductionsupporting

confidence: 69%

Neurotensin-loaded PLGA/CNC composite nanofiber membranes accelerate diabetic wound healing

Zheng

Liu

Huang

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

Self Cite

View full text Add to dashboard Cite

show abstract

“…In particular, electrospun PVA [21], poly(lactic acid) (PLA) [22,23], PEO [24,25], poly(ethylene glycol) (PEG) [26], and poly( ε -caprolactone) (PCL) [27] composite fibers have been successfully reinforced by CNCs. For example, the PLGA nanofiber membranes reinforced with 7 wt % CNCs had a tensile modulus of 21.28 MPa and an ultimate strain of 89.2% ± 5.3%, which are similar to the values of human skin [28]. The flexural strength and flexural modulus of epoxy were increased by 20% and 17% after adding the CNCs, respectively [20].…”

Section: Introductionmentioning

confidence: 96%

Preparation and Properties of Electrospun Poly (Vinyl Pyrrolidone)/Cellulose Nanocrystal/Silver Nanoparticle Composite Fibers

et al. 2016

View full text Add to dashboard Cite

Poly (vinyl pyrrolidone) (PVP)/cellulose nanocrystal (CNC)/silver nanoparticle composite fibers were prepared via electrospinning using N,N′-dimethylformamide (DMF) as a solvent. Rheology, morphology, thermal properties, mechanical properties, and antimicrobial activity of nanocomposites were characterized as a function of material composition. The PVP/CNC/Ag electrospun suspensions exhibited higher conductivity and better rheological properties compared with those of the pure PVP solution. The average diameter of the PVP electrospun fibers decreased with the increase in the amount of CNCs and Ag nanoparticles. Thermal stability of electrospun composite fibers was decreased with the addition of CNCs. The CNCs help increase the composite tensile strength, while the elongation at break decreased. The composite fibers included Ag nanoparticles showed improved antimicrobial activity against both the Gram-negative bacterium Escherichia coli (E. coli) and the Gram-positive bacterium Staphylococcus aureus (S. aureus). The enhanced strength and antimicrobial performances of PVP/CNC/Ag electrospun composite fibers make the mat material an attractive candidate for application in the biomedical field.

show abstract

“…Promising materials for developing nanofibrous degradable scaffolds are synthetic degradable polymers, namely PLAs, [10][11][12] and their copolymers with glycolides 13 or polyethylene glycol. 14 Other examples include poly (epsiloncaprolactone) 15 or segmented copolymers of polyethylene oxide terephthalate and polybutylene terephthalate.…”

mentioning

confidence: 99%

The potential applications of fibrin-coated electrospun polylactide nanofibers in skin tissue engineering

Bačáková¹,

Musı́lková²,

Riedel³

et al. 2016

IJN

View full text Add to dashboard Cite

Fibrin plays an important role during wound healing and skin regeneration. It is often applied in clinical practice for treatment of skin injuries or as a component of skin substitutes. We prepared electrospun nanofibrous membranes made from poly( l -lactide) modified with a thin fibrin nanocoating. Fibrin surrounded the individual fibers in the membrane and also formed a thin fibrous mesh on several places on the membrane surface. The cell-free fibrin nanocoating remained stable in the cell culture medium for 14 days and did not change its morphology. On membranes populated with human dermal fibroblasts, the rate of fibrin degradation correlated with the degree of cell proliferation. The cell spreading, mitochondrial activity, and cell population density were significantly higher on membranes coated with fibrin than on nonmodified membranes, and this cell performance was further improved by the addition of ascorbic acid in the cell culture medium. Similarly, fibrin stimulated the expression and synthesis of collagen I in human dermal fibroblasts, and this effect was further enhanced by ascorbic acid. The expression of beta 1 -integrins was also improved by fibrin, and on pure polylactide membranes, it was slightly enhanced by ascorbic acid. In addition, ascorbic acid promoted deposition of collagen I in the form of a fibrous extracellular matrix. Thus, the combination of nanofibrous membranes with a fibrin nanocoating and ascorbic acid seems to be particularly advantageous for skin tissue engineering.

show abstract

Preparation and properties of PLGA nanofiber membranes reinforced with cellulose nanocrystals

Cited by 97 publications

References 47 publications

Neurotensin-loaded PLGA/CNC composite nanofiber membranes accelerate diabetic wound healing

Neurotensin-loaded PLGA/CNC composite nanofiber membranes accelerate diabetic wound healing

Preparation and Properties of Electrospun Poly (Vinyl Pyrrolidone)/Cellulose Nanocrystal/Silver Nanoparticle Composite Fibers

The potential applications of fibrin-coated electrospun polylactide nanofibers in skin tissue engineering

Contact Info

Product

Resources

About