Neurotensin-loaded PLGA/CNC composite nanofiber membranes accelerate diabetic wound healing

Zheng, Zuoping; Liu, Yishu; Huang, Wenhua; Mo, Yunfei; Lan, Yong; Guo, Rui; Cheng, Biao

doi:10.1080/21691401.2018.1460372

Cited by 52 publications

(32 citation statements)

References 40 publications

(50 reference statements)

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“…Noteworthy, in two different mouse diabetic wound healing studies, delivery of NT with specially designed biomaterials enhanced wound closure. Collagen dressings functionalized with NT reduced inflammation and accelerated wound healing (Moura et al, 2014), whereas PLGA membranes loaded with NT also resulted in more rapid wound healing and decrease in inflammatory cytokine expression (Zheng et al, 2018). Therefore, topical delivery of NT could potentially be a promising treatment for diabetic foot ulcers.…”

Section: Neurotensin (Nt)mentioning

confidence: 99%

Autonomic nerve dysfunction and impaired diabetic wound healing: The role of neuropeptides

Theocharidis

Veves

2020

Autonomic Neuroscience

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Lower extremity ulcerations represent a major complication in diabetes mellitus and involve multiple physiological factors that lead to impairment of wound healing. Neuropeptides are neuromodulators implicated in various processes including diabetic wound healing. Diabetes causes autonomic and small sensory nerve fibers neuropathy as well as inflammatory dysregulation, which manifest with decreased neuropeptide expression and a disproportion in pro-and anti-inflammatory cytokine response. Therefore to fully understand the contribution of autonomic nerve dysfunction in diabetic wound healing it is crucial to explore the implication of neuropeptides. Here, we will discuss recent studies elucidating the role of specific neuropeptides in wound healing.

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Section: Neurotensin (Nt)mentioning

confidence: 99%

Autonomic nerve dysfunction and impaired diabetic wound healing: The role of neuropeptides

Theocharidis

Veves

2020

Autonomic Neuroscience

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“…Both growth factors had a synergistic effect on the proliferation of human skin fibroblasts and increased the expression of genes for collagen and elastin in these cells [90]. Composite nanofibrous membranes containing PLGA and cellulose nanocrystals and loaded with neurotensin accelerated healing of full-thickness skin wounds in spontaneously diabetic mice [91]. Nanofibers created by electrospinning the dispersion composed of polyethyleneimine-carboxymethyl chitosan/pDNA-angiogenin Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic… DOI: http://dx.doi.org/10.5772/intechopen.88744 nanoparticles, curcumin, PLGA, and cellulose nanocrystals showed antimicrobial and regenerative effects when transplanted into the infected full-thickness burn wounds in rats [92].…”

Section: Nanofibers From Synthetic Degradable Polymersmentioning

confidence: 99%

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers

Bačáková¹,

Zikmundová²,

Pajorová³

et al. 2020

Applications of Nanobiotechnology

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Nanofibrous scaffolds are popular materials in all areas of tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. In this chapter, we focused on the application of nanofibers in skin tissue engineering and wound healing, because the skin is an organ with several vitally important functions, particularly barrier, thermoregulatory, and sensory functions. Nanofibrous meshes not only serve as carriers for skin cells but also can prevent the penetration of microbes into wounds and can keep appropriate moisture in the damaged skin. The nanofibrous meshes have been prepared from a wide range of synthetic and nature-derived polymers. This review is concentrated on synthetic non-degradable and degradable polymers, which have been explored for skin tissue engineering and wound healing. These synthetic polymers were often combined with natural polymers of the protein or polysaccharide nature, which improved their attractiveness for cell colonization. The nanofibrous scaffolds can also be loaded with various bioactive molecules, such as growth factors, hormones, vitamins, antioxidants, antimicrobial, and antitumor agents. In advanced tissue engineering approaches, the cells on the nanofibrous scaffolds are cultured in dynamic bioreactors enabling appropriate mechanical stimulation of cells and at air-liquid interface. This chapter summarizes recent results achieved in the field of nanofiber-based skin tissue engineering, including results of our research group.

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“…Zheng et al, demonstrated that a PLGA and cellulose nanocrystal nanofiber membrane not only showed advantageous cytocompatibility, but also stimulated fibroblast adhesion, spreading, and proliferation. The release of neurotensin (NT), an inflammatory moderator, was also observed and researchers noted that the composite membrane allowed for sustained delivery of NT, ultimately promoting reepithelialization for the treatment of DFUs [ 59 ]. Another study created PLGA microspheres with high encapsulation of recombinant human epidermal growth factor (rhEGF) by solvent-evaporation.…”

Section: Current Wound Dressingsmentioning

confidence: 99%

Smart Wound Dressings for Diabetic Chronic Wounds

2018

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Given their severity and non-healing nature, diabetic chronic wounds are a significant concern to the 30.3 million Americans diagnosed with diabetes mellitus (2015). Peripheral arterial diseases, neuropathy, and infection contribute to the development of these wounds, which lead to an increased incidence of lower extremity amputations. Early recognition, debridement, offloading, and controlling infection are imperative for timely treatment. However, wound characterization and treatment are highly subjective and based largely on the experience of the treating clinician. Many wound dressings have been designed to address particular clinical presentations, but a prescriptive method is lacking for identifying the particular state of chronic, non-healing wounds. The authors suggest that recent developments in wound dressings and biosensing may allow for the quantitative, real-time representation of the wound environment, including exudate levels, pathogen concentrations, and tissue regeneration. Development of such sensing capability could enable more strategic, personalized care at the onset of ulceration and limit the infection leading to amputation. This review presents an overview of the pathophysiology of diabetic chronic wounds, a brief summary of biomaterial wound dressing treatment options, and biosensor development for biomarker sensing in the wound environment.

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Neurotensin-loaded PLGA/CNC composite nanofiber membranes accelerate diabetic wound healing

Cited by 52 publications

References 40 publications

Autonomic nerve dysfunction and impaired diabetic wound healing: The role of neuropeptides

Autonomic nerve dysfunction and impaired diabetic wound healing: The role of neuropeptides

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers

Smart Wound Dressings for Diabetic Chronic Wounds

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