The Origin of the Reactive Cells in Cerebral Stab Wounds^*a

Electron Microscopic Study of Macrophages Appearing in a Stab Wound of the Brain of Rats Following Intravenous Injection of Carbon Particles

“…This view that brain macrophages are cells of mesodermal origin has been supported subsequently by many workers using radioautography (KONIGS- MARK and SIDMAN, 1963;HUNTINGTON and TERRY, 1966;KITAMURA et al, 1972;IMAMOTO andLEBLOND, 1977, 1978). Thus, it has been shown that circulating monocytes are the candidate cells which may give rise to brain macrophages both under normal and experimental circumstances.…”

“…In the past few years, it has been demonstrated repeatedly that some of the macrophages appearing in damaged and degenerating neural tissue originate from circulating monocytes (ADRIAN and WALKER, 1962;KONIGSMARK and SIDMAN, 1963;OLSSON and SJOSTRAND, 1964;HUNTINGTON and TERRY, 1966;ADRIAN and SMOTHERMON, 1970;KITAMURA, HATTORI and FUJITA, 1972;ADRIAN and WILLIAMS, 1973). The results of the above-mentioned workers are primarily based on radioautographic studies in which 3H-thymidine was used to label circulating monocytes in different animals before damaging the nervous tissues in various ways, e.g.…”

“…The results of the above-mentioned workers are primarily based on radioautographic studies in which 3H-thymidine was used to label circulating monocytes in different animals before damaging the nervous tissues in various ways, e.g. by stab wound (HUNTINGTON and TERRY, 1966;KITAMURA et al, 1972;KITAMURA, 1973). A more direct approach was by IMAMOTO and LEBLOND (1977) who labelled bone marrow cells in vitro with 3H-uridine, and injected them into a recipient rat with a cortical lesion.…”

Electron Microscopic Observations in the Trigeminal Mesencephalic Nucleus Following Neurotomy of the Third Division of the Trigeminal Nerve

“…Activity of ACP seemed to be preserved till the last, however, G6PDH would not be in the necrotic neurons, because they did not contain the Nissl substances but numerous lamellated dense bodies. GONATAS (1965) andWALLACE et al (1966) (TERRY et al, 1964;TERRY, 1971) or experimental cases after neurotomy (PANNESE, 1963;WISNIEWSKI et al, 1968;BARRON et al, 1969;WISNIEWSKI et al, 1970;ZELENA, 1971) or during drug administration (PRINEAS, 1969) and the in vitro system of tissue culture (SELL et al, 1969 (HUNTINGTON and TERRY, 1966;LAMPERT,1967). MORI andLEBLOND (1969) andMORI (1970) reported that pericytal microglia around vascular walls undergo mitosis and migrate into the brain matrix as phagocytotic cells in the cases of the brain injury, after 5 days.…”

Nature of Macrophages in Rat Brain

“…For some authors, brain macrophages are entirely of hematogenous origin [Konigsmark and Sidman. 1963: Huntington and Terry. 1966: Sato.…”