Electron Microscopic Observations in the Trigeminal Mesencephalic Nucleus Following Neurotomy of the Third Division of the Trigeminal Nerve

Imamoto, Kikuko

doi:10.1679/aohc1950.34.361

Cited by 5 publications

(1 citation statement)

References 35 publications

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“…Although their location is different, the response of the cell bodies is similar to that of those in the ganglion. Transection of the mandibular nerve near the foramen ovale results in chromatolysis in many of the mesencephalic cell bodies and the loss of around 25% of the cells (Imamoto, 1972). Many afferents in the masseteric nerve have their cell bodies in the mesencephalic nucleus.…”

Section: Structural Observationsmentioning

confidence: 99%

Experimental Trigeminal Nerve Injury

Holland

1996

Critical Reviews in Oral Biology & Medicine

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Abstract:The successful reinnervation of peripheral targets after injury varies with the axonal population of the nerve that is injured and the extent of the dislocation of its central component from the peripheral endoneurial tube. Larger-diameter axons such as those supplying mechanoreceptors recover more readily than narrower axons such as those supplying taste. A complex, bi-directional interaction between lingual epithelium and sprouting nerve results in the redifferentiation of taste buds after denervation. Dentin and the dental pulp provide a strong attraction to sprouting nerves and will become reinnervated from collateral sources if recovery of the original innervation is blocked. The most effective repair technique for transected lingual nerves is one which brings the cut ends together rather than one that provides a temporary bridge.Injuries can result in cell death in the trigeminal ganglion but only if the injury is severe and recovery is prevented. Lesser damage results in chromatolysis and the increased expression of neuropeptides. All nerve injuries bring about changes in the trigeminal nucleus. These occur as changes in receptive field and the incidence of spontaneously active neurons, effects which are consistent with the unmasking of existing afferents. These functional changes are short-lived and reversible. Morphologically, nerve injury results in terminal degeneration in the nuclei and an increased expression of the c-Fos gene and some neuropeptides. Only a chronic constriction injury induces behavioral changes. The adult trigeminal system retains considerable plasticity that permits it to respond successfully to nerve injury. Much remains to be learned about this response, particularly of the trophic factors that control peripheral recovery and the central response to more severe injuries.

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Section: Structural Observationsmentioning

confidence: 99%

Experimental Trigeminal Nerve Injury

Holland

1996

Critical Reviews in Oral Biology & Medicine

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Location, morphology, and central projections of mesencephalic trigeminal neurons innervating rat masticatory muscles studied by axonal transport of choleragenoid‐horseradish peroxidase

Raappana

Arvidsson

1993

J of Comparative Neurology

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Retrograde and transganglionic transport of horseradish peroxidase conjugated to the B-fragment of cholera toxin (B-HRP) was used to study the location, morphology, and central projections of mesencephalic trigeminal (Me5) neurons innervating rat masticatory muscles. Labeled Me5 cell bodies were found throughout the Me5 nucleus from a level slightly caudal to the trigeminal motor nucleus to the level of the superior colliculus 5 mm further rostrally. Occasionally, labeled Me5 cells were observed in the anterior medullary velum, in the cerebellum, and in the brainstem contralateral to the B-HRP injection. The vast majority of the labeled Me5 cells were pseudounipolar, but multipolar cells were also found. Extensive central projections from labeled Me5 cells could be seen extending from the nucleus of Darkschewitsch rostrally to the C2 segment caudally. Small but consistent projections from Me5 neurons were observed in nuclear islands among the incoming Me5 root fibers. Trigeminal and hypoglossal motor nuclei received direct projections from Me5 cells, but not the facial motor nucleus. The most prominent Me5 projections appeared in the brainstem reticular formation, including the supratrigeminal nucleus. Smaller projections also extended into the main sensory trigeminal nucleus, trigeminal subnucleus oralis, and the nucleus of the solitary tract.

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The reaction of mesencephalic trigeminal neurons to peripheral nerve transection in the adult rat

Raappana

Arvidsson

1992

Exp Brain Res

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The effects of peripheral nerve transection on mesencephalic trigeminal (MeV) neurons have been studied qualitatively and quantitatively in the rat. In the qualitative part of the study the brain stem was studied in Fink-Heimer stained sections 3-30 days after a masseteric nerve transection. Degeneration argyrophilia was observed both in the MeV tract and in the supratrigeminal and trigeminal motor nuclei, as well as in the lateral part of the brain stem reticular formation. The first signs of transganglionic degeneration (TGD) were seen 7 days postoperatively, and the amount of degeneration increased considerably with longer survival times. A quantitative analysis of the MeV nucleus was made 60 days after transection of the left masseteric nerve. This analysis showed a 10.5-22.7% reduction of cells on the side that had undergone masseteric nerve transection. The mean difference (left vs right side) was -2.4% in animals that had not been operated on. These findings show that mesencephalic trigeminal neurons with proprioceptive functions are very sensitive to peripheral nerve injury with a substantial cell loss and TGD as the result.

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Electron Microscopic Observations in the Trigeminal Mesencephalic Nucleus Following Neurotomy of the Third Division of the Trigeminal Nerve

Cited by 5 publications

References 35 publications

Experimental Trigeminal Nerve Injury

Experimental Trigeminal Nerve Injury

Location, morphology, and central projections of mesencephalic trigeminal neurons innervating rat masticatory muscles studied by axonal transport of choleragenoid‐horseradish peroxidase

The reaction of mesencephalic trigeminal neurons to peripheral nerve transection in the adult rat

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