The ONE‐MIND Study: Rationale and protocol for assessing the effects of ONlinE MINDfulness‐based cancer recovery for the prevention of fatigue and other common side effects during chemotherapy

Abstract

Cancer patients often experience poor quality of life (QoL) during chemotherapy (CT) treatments due to side effects including fatigue, insomnia, pain and nausea/vomiting. Mindfulness‐based cancer recovery (MBCR) is an evidence‐based intervention for treating such symptoms, but has not been investigated as an adjunctive treatment during CT. This study aims to determine the efficacy of an online group MBCR programme delivered during CT in 12 real‐time interactive weekly sessions for managing fatigue (primary outcome). Secondary outcomes include sleep disturbance, pain, nausea/vomiting, mood, stress and QoL. Exploratory outcomes include cognitive function, white blood cell counts and return to work. The study is a two‐armed randomised controlled waitlist trial with 2:1 allocation to treatment (online group MBCR during CT) or control (waitlist usual care; online MBCR following CT completion) with a target sample size of N = 178. Participants are breast or colorectal cancer patients undergoing common CT regimens in Calgary, Canada. Online assessments using validated self‐reported instruments will take place at baseline, post‐MBCR, post‐CT and 12 months’ post‐baseline. If online MBCR delivered during CT significantly reduces fatigue in cancer patients’ post‐CT and also impacts secondary symptoms, this would provide evidence for including mindfulness training as an adjunctive symptom management therapy during CT.

Exploration of interventions to enhance return-to-work for cancer patients: A scoping review

“…Two protocols 23,24 introduced the contents of psychological interventions on return-to-work for cancer patients. The interventions included early active individualized psychological support, psychological consultations, psychological education, and mindfulness meditation therapy.…”

“…Early active individualized psychosocial support 23 provided relaxation skills training and psychological education by faceto-face consultations in the early stages of cancer treatment. Mindfulness-based cancer recovery 24 helped patients develop relaxation and self-acceptance skills through deep breathing, body scans, and mindfulness meditation. These two protocols did not report results and needed to be further validated by experiments.…”

Application of Gold Nanoparticle-Based Materials in Cancer Therapy and Diagnostics

“…After traditional cancer therapy, patients usually take a long time to recover from side effects [10][11][12][13][14][15]. Moreover, most methods are not highly effective against cancer cells, and cancer chemotherapy causes disorders in many body organs (heart, kidneys, bladder, nervous system, and lungs) [16][17][18][19].…”

Distress and Quality of Life Among Patients with Advanced Genitourinary Cancers

“…their cancer experience [25]. Online self-management interventions have also been developed and focus on managing physical symptoms (eg, pain and fatigue) and emotional well-being (distress, anxiety, depression, and fear of cancer recurrence) [26][27][28]. These home-based interventions provide the opportunity to reach more patients and to address common barriers to accessing supportive care (eg, cost and travel).…”